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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: GRIK2_HUMAN (Q13002)

Summary

This is the summary of UniProt entry GRIK2_HUMAN (Q13002).

Description: Glutamate receptor ionotropic, kainate 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 908 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 31
Pfam ANF_receptor 52 398
low_complexity n/a 61 76
disorder n/a 410 417
disorder n/a 419 422
Pfam Lig_chan-Glu_bd 431 546
Pfam Lig_chan 560 831
transmembrane n/a 563 582
transmembrane n/a 639 661
transmembrane n/a 820 844
disorder n/a 902 905
disorder n/a 907 908

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13002. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM
50
51
GAEELAFRFA VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS
100
101
LGVAAIFGPS HSSSANAVQS ICNALGVPHI QTRWKHQVSD NKDSFYVSLY
150
151
PDFSSLSRAI LDLVQFFKWK TVTVVYDDST GLIRLQELIK APSRYNLRLK
200
201
IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK QALAMGMMTE
250
251
YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER
300
301
LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH
350
351
KPWRFGTRFM SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE
400
401
KIGTWDPASG LNMTESQKGK PANITDSLSN RSLIVTTILE EPYVLFKKSD
450
451
KPLYGNDRFE GYCIDLLREL STILGFTYEI RLVEDGKYGA QDDANGQWNG
500
501
MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI LYRKPNGTNP
550
551
GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARFSPYEWY NPHPCNPDSD
600
601
VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS
650
651
YTANLAAFLT VERMESPIDS ADDLAKQTKI EYGAVEDGAT MTFFKKSKIS
700
701
TYDKMWAFMS SRRQSVLVKS NEEGIQRVLT SDYAFLMEST TIEFVTQRNC
750
751
NLTQIGGLID SKGYGVGTPM GSPYRDKITI AILQLQEEGK LHMMKEKWWR
800
801
GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG EFLYKSKKNA
850
851
QLEKRSFCSA MVEELRMSLK CQRRLKHKPQ APVIVKTEEV INMHTFNDRR
900
901
LPGKETMA                                              
908
 

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Checksums:
CRC64:5F34630524401E84
MD5:899a605625e92517d603cdfce21e30ae

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Lig_chan 667 - 800 3QXM A 636 - 769 Jmol OpenAstexViewer
667 - 805 3QXM B 636 - 774 Jmol OpenAstexViewer
Lig_chan-Glu_bd 431 - 544 3QXM A 400 - 513 Jmol OpenAstexViewer
B 400 - 513 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.