Summary
This is the summary of UniProt entry STK4_HUMAN (Q13043).
| Description: | Serine/threonine-protein kinase 4 EC=2.7.11.1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 487 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 5 |
| disorder | n/a | 9 | 10 |
| disorder | n/a | 15 | 18 |
| Pfam | Pkinase | 30 | 281 |
| disorder | n/a | 245 | 247 |
| disorder | n/a | 273 | 276 |
| coiled_coil | n/a | 290 | 310 |
| disorder | n/a | 300 | 403 |
| low_complexity | n/a | 311 | 326 |
| disorder | n/a | 406 | 427 |
| Pfam | Mst1_SARAH | 433 | 480 |
| disorder | n/a | 459 | 465 |
| disorder | n/a | 473 | 475 |
| disorder | n/a | 477 | 481 |
| disorder | n/a | 485 | 487 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q13043. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK
50 51
ETGQIVAIKQ VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI
100 101
VMEYCGAGSV SDIIRLRNKT LTEDEIATIL QSTLKGLEYL HFMRKIHRDI
150 151
KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG
200 201
YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW
250 251
SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV
300 301
KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG
350 351
ANTMIEHDDT LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE
400 401
QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA
450 451
LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQNF
487
Show the unformatted sequence. |
| Checksums: |
CRC64:150758EBC5F77D5C
MD5:f2f8bb4872f5b5807c5f0d903f09b056
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Mst1_SARAH | 433 - 480 | 2JO8 | A | 4 - 51 | NGL View in InterPro |
| B | 104 - 151 | NGL View in InterPro | |||
| 4NR2 | A | 433 - 480 | NGL View in InterPro | ||
| C | 433 - 480 | NGL View in InterPro | |||
| D | 433 - 480 | NGL View in InterPro | |||
| E | 433 - 480 | NGL View in InterPro | |||
| G | 433 - 480 | NGL View in InterPro | |||
| H | 433 - 480 | NGL View in InterPro | |||
| 434 - 480 | 4NR2 | B | 434 - 480 | NGL View in InterPro | |
| F | 434 - 480 | NGL View in InterPro | |||
| 438 - 480 | 4OH8 | A | 9 - 51 | NGL View in InterPro | |
| Pkinase | 30 - 281 | 3COM | A | 30 - 281 | NGL View in InterPro |
| B | 30 - 281 | NGL View in InterPro | |||
| 6YAT | A | 30 - 281 | NGL View in InterPro | ||
| B | 30 - 281 | NGL View in InterPro |
The parts of the structure corresponding to the Pfam family are highlighted in yellow.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
