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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: STK4_HUMAN (Q13043)

Summary

This is the summary of UniProt entry STK4_HUMAN (Q13043).

Description: Serine/threonine-protein kinase 4 EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 487 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 5
disorder n/a 9 10
disorder n/a 15 18
Pfam Pkinase 30 281
disorder n/a 245 247
disorder n/a 273 276
coiled_coil n/a 290 310
disorder n/a 300 403
low_complexity n/a 311 326
disorder n/a 406 427
Pfam Mst1_SARAH 433 480
disorder n/a 459 465
disorder n/a 473 475
disorder n/a 477 481
disorder n/a 485 487

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13043. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK
50
51
ETGQIVAIKQ VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI
100
101
VMEYCGAGSV SDIIRLRNKT LTEDEIATIL QSTLKGLEYL HFMRKIHRDI
150
151
KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG
200
201
YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW
250
251
SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV
300
301
KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG
350
351
ANTMIEHDDT LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE
400
401
QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA
450
451
LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQNF              
487
 

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Checksums:
CRC64:150758EBC5F77D5C
MD5:f2f8bb4872f5b5807c5f0d903f09b056

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Mst1_SARAH 433 - 480 2JO8 A 4 - 51 NGL View in InterPro
B 104 - 151 NGL View in InterPro
4NR2 A 433 - 480 NGL View in InterPro
C 433 - 480 NGL View in InterPro
D 433 - 480 NGL View in InterPro
E 433 - 480 NGL View in InterPro
G 433 - 480 NGL View in InterPro
H 433 - 480 NGL View in InterPro
434 - 480 4NR2 B 434 - 480 NGL View in InterPro
F 434 - 480 NGL View in InterPro
438 - 480 4OH8 A 9 - 51 NGL View in InterPro
Pkinase 30 - 281 3COM A 30 - 281 NGL View in InterPro
B 30 - 281 NGL View in InterPro
6YAT A 30 - 281 NGL View in InterPro
B 30 - 281 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.