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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CSN1_HUMAN (Q13098)

Summary

This is the summary of UniProt entry CSN1_HUMAN (Q13098).

Description: COP9 signalosome complex subunit 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 491 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 16 36
disorder n/a 102 103
disorder n/a 106 118
Pfam RPN7 127 309
low_complexity n/a 131 149
coiled_coil n/a 135 155
disorder n/a 230 234
disorder n/a 236 237
low_complexity n/a 311 314
Pfam PCI 324 428
coiled_coil n/a 390 410
disorder n/a 465 491

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13098. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLPVQVFNL QGAVEPMQID VDPQEDPQNA PDVNYVVENP SLDLEQYAAS
50
51
YSGLMRIERL QFIADHCPTL RVEALKMALS FVQRTFNVDM YEEIHRKLSE
100
101
ATRSSLRELQ NAPDAIPESG VEPPALDTAW VEATRKKALL KLEKLDTDLK
150
151
NYKGNSIKES IRRGHDDLGD HYLDCGDLSN ALKCYSRARD YCTSAKHVIN
200
201
MCLNVIKVSV YLQNWSHVLS YVSKAESTPE IAEQRGERDS QTQAILTKLK
250
251
CAAGLAELAA RKYKQAAKCL LLASFDHCDF PELLSPSNVA IYGGLCALAT
300
301
FDRQELQRNV ISSSSFKLFL ELEPQVRDII FKFYESKYAS CLKMLDEMKD
350
351
NLLLDMYLAP HVRTLYTQIR NRALIQYFSP YVSADMHRMA AAFNTTVAAL
400
401
EDELTQLILE GLISARVDSH SKILYARDVD QRSTTFEKSL LMGKEFQRRA
450
451
KAMMLRAAVL RNQIHVKSPP REGSQGELTP ANSQSRMSTN M         
491
 

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Checksums:
CRC64:BF925164ED985638
MD5:c9525bbc3ddb3ad5836eaa6ffb7ee72f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PCI 324 - 428 4D10 A 360 - 464 Jmol OpenAstexViewer
I 360 - 464 Jmol OpenAstexViewer
4D18 A 360 - 464 Jmol OpenAstexViewer
I 360 - 464 Jmol OpenAstexViewer
4WSN A 360 - 464 Jmol OpenAstexViewer
g 360 - 464 Jmol OpenAstexViewer
I 360 - 464 Jmol OpenAstexViewer
o 360 - 464 Jmol OpenAstexViewer
Q 360 - 464 Jmol OpenAstexViewer
Y 360 - 464 Jmol OpenAstexViewer
6R6H A 360 - 464 Jmol OpenAstexViewer
6R7F A 324 - 428 Jmol OpenAstexViewer
6R7H A 324 - 428 Jmol OpenAstexViewer
6R7I A 360 - 464 Jmol OpenAstexViewer
6R7N A 360 - 464 Jmol OpenAstexViewer
RPN7 127 - 309 4D10 A 163 - 345 Jmol OpenAstexViewer
I 163 - 345 Jmol OpenAstexViewer
4D18 A 163 - 345 Jmol OpenAstexViewer
I 163 - 345 Jmol OpenAstexViewer
4WSN A 163 - 345 Jmol OpenAstexViewer
g 163 - 345 Jmol OpenAstexViewer
I 163 - 345 Jmol OpenAstexViewer
o 163 - 345 Jmol OpenAstexViewer
Q 163 - 345 Jmol OpenAstexViewer
Y 163 - 345 Jmol OpenAstexViewer
6R6H A 163 - 345 Jmol OpenAstexViewer
6R7F A 127 - 309 Jmol OpenAstexViewer
6R7H A 127 - 309 Jmol OpenAstexViewer
6R7I A 163 - 345 Jmol OpenAstexViewer
6R7N A 163 - 345 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.