Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CBX3_HUMAN (Q13185)

Summary

This is the summary of UniProt entry CBX3_HUMAN (Q13185).

Description: Chromobox protein homolog 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 183 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 28
low_complexity n/a 8 20
low_complexity n/a 17 34
Pfam Chromo 30 79
disorder n/a 84 115
low_complexity n/a 89 112
disorder n/a 121 124
Pfam Chromo_shadow 122 174
disorder n/a 178 183

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13185. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASNKTTLQK MGKKQNGKSK KVEEAEPEEF VVEKVLDRRV VNGKVEYFLK
50
51
WKGFTDADNT WEPEENLDCP ELIEAFLNSQ KAGKEKDGTK RKSLSDSESD
100
101
DSKSKKKRDA ADKPRGFARG LDPERIIGAT DSSGELMFLM KWKDSDEADL
150
151
VLAKEANMKC PQIVIAFYEE RLTWHSCPED EAQ                  
183
 

Show the unformatted sequence.

Checksums:
CRC64:5928C63E0C93A76A
MD5:8b87c17b8cdc3ab4c67a37f4fe4d9ca3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Chromo 30 - 79 2L11 A 3 - 52 Jmol OpenAstexViewer
3DM1 A 30 - 79 Jmol OpenAstexViewer
C 30 - 79 Jmol OpenAstexViewer
E 30 - 79 Jmol OpenAstexViewer
G 30 - 79 Jmol OpenAstexViewer
3TZD A 30 - 79 Jmol OpenAstexViewer
Chromo_shadow 122 - 172 3KUP A 122 - 172 Jmol OpenAstexViewer
C 122 - 172 Jmol OpenAstexViewer
122 - 173 3KUP B 122 - 173 Jmol OpenAstexViewer
D 122 - 173 Jmol OpenAstexViewer
122 - 174 5T1I A 122 - 174 Jmol OpenAstexViewer
B 122 - 174 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.