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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TBX2_HUMAN (Q13207)

Summary

This is the summary of UniProt entry TBX2_HUMAN (Q13207).

Description: T-box transcription factor TBX2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 712 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 49
low_complexity n/a 28 75
disorder n/a 87 108
low_complexity n/a 96 105
Pfam T-box 107 287
disorder n/a 184 189
disorder n/a 277 468
Pfam TBX 305 384
low_complexity n/a 392 404
low_complexity n/a 423 441
disorder n/a 476 477
disorder n/a 482 484
disorder n/a 490 491
disorder n/a 516 520
low_complexity n/a 516 548
disorder n/a 522 535
low_complexity n/a 581 603
disorder n/a 623 624
disorder n/a 639 692
coiled_coil n/a 681 701
disorder n/a 695 712

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13207. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK
50
51
PLPDPGLAGA AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE
100
101
VEDDPKVTLE AKELWDQFHK LGTEMVITKS GRRMFPPFKV RVSGLDKKAK
150
151
YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP DSPATGEQWM
200
201
AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF
250
251
RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT
300
301
LPSLRLYEEH CKPERDGAES DASSCDPPPA REPPTSPGAA PSPLRLHRAR
350
351
AEEKSCAADS DPEPERLSEE RAGAPLGRSP APDSASPTRL TEPERARERR
400
401
SPERGKEPAE SGGDGPFGLR SLEKERAEAR RKDEGRKEAA EGKEQGLAPL
450
451
VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF LHPGQFTMGP
500
501
GAFSAMGMGH LLASVAGGGN GGGGGPGTAA GLDAGGLGPA ASAASTAAPF
550
551
PFHLSQHMLA SQGIPMPTFG GLFPYPYTYM AAAAAAASAL PATSAAAAAA
600
601
AAAGSLSRSP FLGSARPRLR FSPYQIPVTI PPSTSLLTTG LASEGSKAAG
650
651
GNSREPSPLP ELALRKVGAP SRGALSPSGS AKEAANELQS IQRLVSGLES
700
701
QRALSPGRES PK                                         
712
 

Show the unformatted sequence.

Checksums:
CRC64:5C890DFC10FC3B68
MD5:81215d475a03d95de417d2fe9d7f6758

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;