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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ERCC8_HUMAN (Q13216)

Summary

This is the summary of UniProt entry ERCC8_HUMAN (Q13216).

Description: DNA excision repair protein ERCC-8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 396 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam WD40 85 128
Pfam WD40 176 215
Pfam WD40 222 273
disorder n/a 235 239
Pfam WD40 324 362
disorder n/a 372 373
disorder n/a 376 378
disorder n/a 382 384

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13216. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLGFLSARQT GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHGGGINTLD
50
51
IEPVEGRYML SGGSDGVIVL YDLENSSRQS YYTCKAVCSI GRDHPDVHRY
100
101
SVETVQWYPH DTGMFTSSSF DKTLKVWDTN TLQTADVFNF EETVYSHHMS
150
151
PVSTKHCLVA VGTRGPKVQL CDLKSGSCSH ILQGHRQEIL AVSWSPRYDY
200
201
ILATASADSR VKLWDVRRAS GCLITLDQHN GKKSQAVESA NTAHNGKVNG
250
251
LCFTSDGLHL LTVGTDNRMR LWNSSNGENT LVNYGKVCNN SKKGLKFTVS
300
301
CGCSSEFVFV PYGSTIAVYT VYSGEQITML KGHYKTVDCC VFQSNFQELY
350
351
SGSRDCNILA WVPSLYEPVP DDDETTTKSQ LNPAFEDAWS SSDEEG    
396
 

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Checksums:
CRC64:EC962D56226D717B
MD5:417d0e3314bf8dc9442f16435eb07f7e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
WD40 176 - 215 4A11 B 176 - 215 Jmol OpenAstexViewer
6FCV B 176 - 215 Jmol OpenAstexViewer
222 - 273 4A11 B 222 - 273 Jmol OpenAstexViewer
6FCV B 222 - 273 Jmol OpenAstexViewer
324 - 362 4A11 B 324 - 362 Jmol OpenAstexViewer
6FCV B 324 - 362 Jmol OpenAstexViewer
85 - 128 4A11 B 85 - 128 Jmol OpenAstexViewer
6FCV B 85 - 128 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.