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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: NOGG_HUMAN (Q13253)

Summary

This is the summary of UniProt entry NOGG_HUMAN (Q13253).

Description: Noggin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 232 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 27
Pfam Noggin 12 232
disorder n/a 28 34
disorder n/a 41 42
disorder n/a 44 49
disorder n/a 57 58
disorder n/a 77 96
low_complexity n/a 88 97
disorder n/a 106 108
low_complexity n/a 130 145
low_complexity n/a 203 216

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13253. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP
50
51
DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED
100
101
LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW
150
151
SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL
200
201
TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC                   
232
 

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Checksums:
CRC64:FCA0D8E1E2098580
MD5:0eb399cdf63dd07aa64a52ac40b8c4b9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Noggin 28 - 232 1M4U A 28 - 232 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.