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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SKP2_HUMAN (Q13309)

Summary

This is the summary of UniProt entry SKP2_HUMAN (Q13309).

Description: S-phase kinase-associated protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 424 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 8
disorder n/a 35 39
disorder n/a 41 47
disorder n/a 49 70
Pfam F-box-like 97 143

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13309. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN
50
51
IPQELLSNLG HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL
100
101
PDELLLGIFS CLCLPELLKV SGVCKRWYRL ASDESLWQTL DLTGKNLHPD
150
151
VTGRLLSQGV IAFRCPRSFM DQPLAEHFSP FRVQHMDLSN SVIEVSTLHG
200
201
ILSQCSKLQN LSLEGLRLSD PIVNTLAKNS NLVRLNLSGC SGFSEFALQT
250
251
LLSSCSRLDE LNLSWCFDFT EKHVQVAVAH VSETITQLNL SGYRKNLQKS
300
301
DLSTLVRRCP NLVHLDLSDS VMLKNDCFQE FFQLNYLQHL SLSRCYDIIP
350
351
ETLLELGEIP TLKTLQVFGI VPDGTLQLLK EALPHLQINC SHFTTIARPT
400
401
IGNKKNQEIW GIKCRLTLQK PSCL                            
424
 

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Checksums:
CRC64:F29B7C338A7A37E9
MD5:de0565e63f6807e93cc66a7c797d91f5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
F-box-like 97 - 137 1FS1 A 109 - 149 Jmol OpenAstexViewer
C 109 - 149 Jmol OpenAstexViewer
1LDK E 3109 - 3149 Jmol OpenAstexViewer
97 - 141 1FS2 A 109 - 153 Jmol OpenAstexViewer
C 109 - 153 Jmol OpenAstexViewer
97 - 143 1FQV A 109 - 155 Jmol OpenAstexViewer
C 109 - 155 Jmol OpenAstexViewer
E 109 - 155 Jmol OpenAstexViewer
G 109 - 155 Jmol OpenAstexViewer
I 109 - 155 Jmol OpenAstexViewer
K 109 - 155 Jmol OpenAstexViewer
M 109 - 155 Jmol OpenAstexViewer
O 109 - 155 Jmol OpenAstexViewer
2ASS B 2097 - 2143 Jmol OpenAstexViewer
2AST B 2097 - 2143 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.