Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FZD5_HUMAN (Q13467)

Summary

This is the summary of UniProt entry FZD5_HUMAN (Q13467).

Description: Frizzled-5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 585 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 2
sig_p n/a 1 26
low_complexity n/a 1 27
Pfam Fz 33 141
disorder n/a 57 58
disorder n/a 159 170
low_complexity n/a 161 186
disorder n/a 174 176
Pfam Frizzled 226 537
transmembrane n/a 237 259
transmembrane n/a 271 291
transmembrane n/a 311 344
transmembrane n/a 356 378
low_complexity n/a 401 423
transmembrane n/a 408 429
transmembrane n/a 450 471
transmembrane n/a 500 522
disorder n/a 563 564
disorder n/a 567 568

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13467. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH
50
51
MPNQFNHDTQ DEAGLEVHQF WPLVEIQCSP DLRFFLCSMY TPICLPDYHK
100
101
PLPPCRSVCE RAKAGCSPLM RQYGFAWPER MSCDRLPVLG RDAEVLCMDY
150
151
NRSEATTAPP RPFPAKPTLP GPPGAPASGG ECPAGGPFVC KCREPFVPIL
200
201
KESHPLYNKV RTGQVPNCAV PCYQPSFSAD ERTFATFWIG LWSVLCFIST
250
251
STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR
300
301
EHNHIHYETT GPALCTIVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN
350
351
EAIAGYAQYF HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL
400
401
RGFVLGPLVL YLLVGTLFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI
450
451
GIFTLLYTVP ASIVVACYLY EQHYRESWEA ALTCACPGHD TGQPRAKPEY
500
501
WVLMLKYFMC LVVGITSGVW IWSGKTVESW RRFTSRCCCR PRRGHKSGGA
550
551
MAAGDYPEAS AALTGRTGPP GPAATYHKQV SLSHV                
585
 

Show the unformatted sequence.

Checksums:
CRC64:AC3AB2CD912C1B0A
MD5:e2bcd306f064eee33f42291086714a91

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Fz 33 - 141 5URY A 8 - 116 Jmol OpenAstexViewer
B 8 - 116 Jmol OpenAstexViewer
5URZ A 8 - 116 Jmol OpenAstexViewer
B 8 - 116 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.