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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NFAC2_HUMAN (Q13469)

Summary

This is the summary of UniProt entry NFAC2_HUMAN (Q13469).

Description: Nuclear factor of activated T-cells, cytoplasmic 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 925 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 39
low_complexity n/a 39 46
disorder n/a 41 66
disorder n/a 71 74
disorder n/a 76 101
disorder n/a 108 113
disorder n/a 115 116
disorder n/a 120 121
disorder n/a 148 149
low_complexity n/a 167 184
disorder n/a 187 209
disorder n/a 212 298
low_complexity n/a 233 252
low_complexity n/a 263 280
disorder n/a 314 339
low_complexity n/a 325 338
disorder n/a 354 358
disorder n/a 362 368
Pfam RHD_DNA_bind 410 570
disorder n/a 410 437
disorder n/a 440 442
disorder n/a 571 576
Pfam RHD_dimer 579 679
disorder n/a 608 610
disorder n/a 621 627
disorder n/a 671 682
disorder n/a 686 696
disorder n/a 700 701
disorder n/a 705 709
disorder n/a 733 740
disorder n/a 742 750
disorder n/a 782 786
disorder n/a 788 819
disorder n/a 833 925

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13469. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNAPERQPQP DGGDAPGHEP GGSPQDELDF SILFDYEYLN PNEEEPNAHK
50
51
VASPPSGPAY PDDVLDYGLK PYSPLASLSG EPPGRFGEPD RVGPQKFLSA
100
101
AKPAGASGLS PRIEITPSHE LIQAVGPLRM RDAGLLVEQP PLAGVAASPR
150
151
FTLPVPGFEG YREPLCLSPA SSGSSASFIS DTFSPYTSPC VSPNNGGPDD
200
201
LCPQFQNIPA HYSPRTSPIM SPRTSLAEDS CLGRHSPVPR PASRSSSPGA
250
251
KRRHSCAEAL VALPPGASPQ RSRSPSPQPS SHVAPQDHGS PAGYPPVAGS
300
301
AVIMDALNSL ATDSPCGIPP KMWKTSPDPS PVSAAPSKAG LPRHIYPAVE
350
351
FLGPCEQGER RNSAPESILL VPPTWPKPLV PAIPICSIPV TASLPPLEWP
400
401
LSSQSGSYEL RIEVQPKPHH RAHYETEGSR GAVKAPTGGH PVVQLHGYME
450
451
NKPLGLQIFI GTADERILKP HAFYQVHRIT GKTVTTTSYE KIVGNTKVLE
500
501
IPLEPKNNMR ATIDCAGILK LRNADIELRK GETDIGRKNT RVRLVFRVHI
550
551
PESSGRIVSL QTASNPIECS QRSAHELPMV ERQDTDSCLV YGGQQMILTG
600
601
QNFTSESKVV FTEKTTDGQQ IWEMEATVDK DKSQPNMLFV EIPEYRNKHI
650
651
RTPVKVNFYV INGKRKRSQP QHFTYHPVPA IKTEPTDEYD PTLICSPTHG
700
701
GLGSQPYYPQ HPMVAESPSC LVATMAPCQQ FRTGLSSPDA RYQQQNPAAV
750
751
LYQRSKSLSP SLLGYQQPAL MAAPLSLADA HRSVLVHAGS QGQSSALLHP
800
801
SPTNQQASPV IHYSPTNQQL RCGSHQEFQH IMYCENFAPG TTRPGPPPVS
850
851
QGQRLSPGSY PTVIQQQNAT SQRAAKNGPP VSDQKEVLPA GVTIKQEQNL
900
901
DQTYLDDVNE IIRKEFSGPP ARNQT                           
925
 

Show the unformatted sequence.

Checksums:
CRC64:8DAE86855CCB58D3
MD5:6621eb65913749adc8191ef1f06ec6c6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RHD_dimer 579 - 678 1A02 N 579 - 678 Jmol OpenAstexViewer
1OWR M 579 - 678 Jmol OpenAstexViewer
N 579 - 678 Jmol OpenAstexViewer
P 579 - 678 Jmol OpenAstexViewer
Q 579 - 678 Jmol OpenAstexViewer
1P7H L 579 - 678 Jmol OpenAstexViewer
M 579 - 678 Jmol OpenAstexViewer
N 579 - 678 Jmol OpenAstexViewer
O 579 - 678 Jmol OpenAstexViewer
1PZU B 579 - 678 Jmol OpenAstexViewer
D 579 - 678 Jmol OpenAstexViewer
H 579 - 678 Jmol OpenAstexViewer
I 579 - 678 Jmol OpenAstexViewer
L 579 - 678 Jmol OpenAstexViewer
M 579 - 678 Jmol OpenAstexViewer
1S9K C 579 - 678 Jmol OpenAstexViewer
2AS5 M 579 - 678 Jmol OpenAstexViewer
N 579 - 678 Jmol OpenAstexViewer
2O93 L 579 - 678 Jmol OpenAstexViewer
M 579 - 678 Jmol OpenAstexViewer
O 579 - 678 Jmol OpenAstexViewer
3QRF M 579 - 678 Jmol OpenAstexViewer
N 579 - 678 Jmol OpenAstexViewer
RHD_DNA_bind 410 - 570 1A02 N 410 - 570 Jmol OpenAstexViewer
1OWR M 410 - 570 Jmol OpenAstexViewer
N 410 - 570 Jmol OpenAstexViewer
P 410 - 570 Jmol OpenAstexViewer
Q 410 - 570 Jmol OpenAstexViewer
1P7H L 410 - 570 Jmol OpenAstexViewer
M 410 - 570 Jmol OpenAstexViewer
N 410 - 570 Jmol OpenAstexViewer
O 410 - 570 Jmol OpenAstexViewer
1PZU B 410 - 570 Jmol OpenAstexViewer
D 410 - 570 Jmol OpenAstexViewer
H 410 - 570 Jmol OpenAstexViewer
I 410 - 570 Jmol OpenAstexViewer
L 410 - 570 Jmol OpenAstexViewer
M 410 - 570 Jmol OpenAstexViewer
1S9K C 410 - 570 Jmol OpenAstexViewer
2AS5 M 410 - 570 Jmol OpenAstexViewer
N 410 - 570 Jmol OpenAstexViewer
2O93 L 410 - 570 Jmol OpenAstexViewer
M 410 - 570 Jmol OpenAstexViewer
O 410 - 570 Jmol OpenAstexViewer
3QRF M 410 - 570 Jmol OpenAstexViewer
N 410 - 570 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.