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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TOP3A_HUMAN (Q13472)

Summary

This is the summary of UniProt entry TOP3A_HUMAN (Q13472).

Description: DNA topoisomerase 3-alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1001 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Toprim 36 181
Pfam Topoisom_bac 195 607
disorder n/a 391 397
disorder n/a 400 424
disorder n/a 502 512
Pfam zf-C4_Topoisom 655 694
disorder n/a 751 803
low_complexity n/a 794 805
disorder n/a 806 808
Pfam zf-GRF 811 852
disorder n/a 849 850
disorder n/a 854 869
low_complexity n/a 854 869
disorder n/a 875 887
low_complexity n/a 882 896
Pfam zf-GRF 895 939
disorder n/a 895 896
disorder n/a 907 921
disorder n/a 933 938
disorder n/a 941 985
disorder n/a 997 1001

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13472. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MIFPVARYAL RWLRRPEDRA FSRAAMEMAL RGVRKVLCVA EKNDAAKGIA
50
51
DLLSNGRMRR REGLSKFNKI YEFDYHLYGQ NVTMVMTSVS GHLLAHDFQM
100
101
QFRKWQSCNP LVLFEAEIEK YCPENFVDIK KTLERETRQC QALVIWTDCD
150
151
REGENIGFEI IHVCKAVKPN LQVLRARFSE ITPHAVRTAC ENLTEPDQRV
200
201
SDAVDVRQEL DLRIGAAFTR FQTLRLQRIF PEVLAEQLIS YGSCQFPTLG
250
251
FVVERFKAIQ AFVPEIFHRI KVTHDHKDGI VEFNWKRHRL FNHTACLVLY
300
301
QLCVEDPMAT VVEVRSKPKS KWRPQALDTV ELEKLASRKL RINAKETMRI
350
351
AEKLYTQGYI SYPRTETNIF PRDLNLTVLV EQQTPDPRWG AFAQSILERG
400
401
GPTPRNGNKS DQAHPPIHPT KYTNNLQGDE QRLYEFIVRH FLACCSQDAQ
450
451
GQETTVEIDI AQERFVAHGL MILARNYLDV YPYDHWSDKI LPVYEQGSHF
500
501
QPSTVEMVDG ETSPPKLLTE ADLIALMEKH GIGTDATHAE HIETIKARMY
550
551
VGLTPDKRFL PGHLGMGLVE GYDSMGYEMS KPDLRAELEA DLKLICDGKK
600
601
DKFVVLRQQV QKYKQVFIEA VAKAKKLDEA LAQYFGNGTE LAQQEDIYPA
650
651
MPEPIRKCPQ CNKDMVLKTK KNGGFYLSCM GFPECRSAVW LPDSVLEASR
700
701
DSSVCPVCQP HPVYRLKLKF KRGSLPPTMP LEFVCCIGGC DDTLREILDL
750
751
RFSGGPPRAS QPSGRLQANQ SLNRMDNSQH PQPADSRQTG SSKALAQTLP
800
801
PPTAAGESNS VTCNCGQEAV LLTVRKEGPN RGRQFFKCNG GSCNFFLWAD
850
851
SPNPGAGGPP ALAYRPLGAS LGCPPGPGIH LGGFGNPGDG SGSGTSCLCS
900
901
QPSVTRTVQK DGPNKGRQFH TCAKPREQQC GFFQWVDENT APGTSGAPSW
950
951
TGDRGRTLES EARSKRPRAS SSDMGSTAKK PRKCSLCHQP GHTRPFCPQN
1000
1001
R                                                     
1001
 

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Checksums:
CRC64:06558C749569E0C2
MD5:1dd36e0cf0b2fa143da20ee502abff13

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Topoisom_bac 195 - 607 4CGY A 195 - 607 NGL View in InterPro
4CHT A 195 - 607 NGL View in InterPro
Toprim 36 - 181 4CGY A 36 - 181 NGL View in InterPro
4CHT A 36 - 181 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.