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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IL18R_HUMAN (Q13478)

Summary

This is the summary of UniProt entry IL18R_HUMAN (Q13478).

Description: Interleukin-18 receptor 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 541 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
Pfam Ig_6 72 119
low_complexity n/a 153 167
disorder n/a 261 264
transmembrane n/a 331 351
low_complexity n/a 331 349
Pfam TIR 377 540

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13478. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE
50
51
TTTKSWYKSS GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM
100
101
KNYTQKWKLN VIRRNKHSCF TERQVTSKIV EVKKFFQITC ENSYYQTLVN
150
151
STSLYKNCKK LLLENNKNPT IKKNAEFEDQ GYYSCVHFLH HNGKLFNITK
200
201
TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL LNEEDVIYWM
250
251
FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV
300
301
ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI
350
351
YRVDLVLFYR HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL
400
401
PRVLEKHFGY KLCIFERDVV PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN
450
451
EVRYELESGL HEALVERKIK IILIEFTPVT DFTFLPQSLK LLKSHRVLKW
500
501
KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE S         
541
 

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Checksums:
CRC64:7173DB9C7EA71D32
MD5:280723545a81a3f560e585edecbc34c8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ig_6 72 - 119 3WO3 B 72 - 119 Jmol OpenAstexViewer
D 72 - 119 Jmol OpenAstexViewer
H 72 - 119 Jmol OpenAstexViewer
3WO4 B 72 - 119 Jmol OpenAstexViewer
73 - 119 3WO3 J 73 - 119 Jmol OpenAstexViewer
74 - 119 3WO3 F 74 - 119 Jmol OpenAstexViewer
75 - 119 3WO3 L 75 - 119 Jmol OpenAstexViewer
4R6U A 75 - 119 Jmol OpenAstexViewer
C 75 - 119 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.