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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RIPK1_HUMAN (Q13546)

Summary

This is the summary of UniProt entry RIPK1_HUMAN (Q13546).

Description: Receptor-interacting serine/threonine-protein kinase 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 671 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PK_Tyr_Ser-Thr 18 285
disorder n/a 176 180
coiled_coil n/a 294 314
disorder n/a 301 302
disorder n/a 327 351
disorder n/a 353 478
disorder n/a 480 491
disorder n/a 495 498
disorder n/a 500 519
disorder n/a 521 522
Pfam RHIM 529 549
low_complexity n/a 552 563
disorder n/a 557 562
Pfam Death 584 669

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13546. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG
50
51
PNCIEHNEAL LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL
100
101
MHVLKAEMST PLSVKGRIIL EIIEGMCYLH GKGVIHKDLK PENILVDNDF
150
151
HIKIADLGLA SFKMWSKLNN EEHNELREVD GTAKKNGGTL YYMAPEHLND
200
201
VNAKPTEKSD VYSFAVVLWA IFANKEPYEN AICEQQLIMC IKSGNRPDVD
250
251
DITEYCPREI ISLMKLCWEA NPEARPTFPG IEEKFRPFYL SQLEESVEED
300
301
VKSLKKEYSN ENAVVKRMQS LQLDCVAVPS SRSNSATEQP GSLHSSQGLG
350
351
MGPVEESWFA PSLEHPQEEN EPSLQSKLQD EANYHLYGSR MDRQTKQQPR
400
401
QNVAYNREEE RRRRVSHDPF AQQRPYENFQ NTEGKGTAYS SAASHGNAVH
450
451
QPSGLTSQPQ VLYQNNGLYS SHGFGTRPLD PGTAGPRVWY RPIPSHMPSL
500
501
HNIPVPETNY LGNTPTMPFS SLPPTDESIK YTIYNSTGIQ IGAYNYMEIG
550
551
GTSSSLLDST NTNFKEEPAA KYQAIFDNTT SLTDKHLDPI RENLGKHWKN
600
601
CARKLGFTQS QIDEIDHDYE RDGLKEKVYQ MLQKWVMREG IKGATVGKLA
650
651
QALHQCSRID LLSSLIYVSQ N                               
671
 

Show the unformatted sequence.

Checksums:
CRC64:976E2428D525A9B2
MD5:259f91067e4215f9dc29a11d6cad461f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Death 584 - 669 6AC5 A 584 - 669 Show 3D Structure View in InterPro
PK_Tyr_Ser-Thr 18 - 285 4ITH A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
4ITI A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
4ITJ A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
4NEU A 18 - 285 Show 3D Structure View in InterPro
5HX6 A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
5TX5 A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
6C3E A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
6C4D A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
C 18 - 285 Show 3D Structure View in InterPro
D 18 - 285 Show 3D Structure View in InterPro
6HHO A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
6NW2 A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
6NYH A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
6OCQ A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
6R5F B 18 - 285 Show 3D Structure View in InterPro
C 18 - 285 Show 3D Structure View in InterPro
D 18 - 285 Show 3D Structure View in InterPro
6RLN A 18 - 285 Show 3D Structure View in InterPro
B 18 - 285 Show 3D Structure View in InterPro
190 - 198 7CJB L 190 - 198 Show 3D Structure View in InterPro
190 - 199 7CJB D 190 - 199 Show 3D Structure View in InterPro
191 - 197 7CJB H 191 - 197 Show 3D Structure View in InterPro
P 191 - 197 Show 3D Structure View in InterPro
20 - 285 4NEU B 20 - 285 Show 3D Structure View in InterPro
32 - 285 6R5F A 32 - 285 Show 3D Structure View in InterPro
RHIM 532 - 549 5V7Z B 532 - 549 Show 3D Structure View in InterPro
D 532 - 549 Show 3D Structure View in InterPro
F 532 - 549 Show 3D Structure View in InterPro
H 532 - 549 Show 3D Structure View in InterPro
539 - 542 5ZMZ A 1 - 4 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;