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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: KCC2B_HUMAN (Q13554)

Summary

This is the summary of UniProt entry KCC2B_HUMAN (Q13554).

Description: Calcium/calmodulin-dependent protein kinase type II subunit beta EC=2.7.11.17
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 666 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Pkinase 14 272
transmembrane n/a 197 215
disorder n/a 315 485
low_complexity n/a 319 335
low_complexity n/a 430 447
low_complexity n/a 467 490
disorder n/a 488 545
low_complexity n/a 510 532
Pfam CaMKII_AD 534 661
disorder n/a 602 603
disorder n/a 629 631
disorder n/a 633 643

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13554. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL
50
51
SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE
100
101
DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG
150
151
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC
200
201
GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN
250
251
QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL
300
301
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD
350
351
GVKPQTNSTK NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT
400
401
TIEDEDAKAP RVPDILSSVR RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI
450
451
SDILNSVRRG SGTPEAEGPL SAGPPPCLSP ALLGPLSSPS PRISDILNSV
500
501
RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK TTEQLIEAVN
550
551
NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT
600
601
TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW
650
651
QNVHFHCSGA PVAPLQ                                     
666
 

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Checksums:
CRC64:8CACFC3E392C3857
MD5:14af4e847b53f1b22ddeeb4d1ea574ed

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 14 - 272 3BHH A 14 - 272 Jmol OpenAstexViewer
B 14 - 272 Jmol OpenAstexViewer
C 14 - 272 Jmol OpenAstexViewer
D 14 - 272 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.