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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IQGA2_HUMAN (Q13576)

Summary

This is the summary of UniProt entry IQGA2_HUMAN (Q13576).

Description: Ras GTPase-activating-like protein IQGAP2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1575 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 5
disorder n/a 10 11
disorder n/a 20 22
disorder n/a 24 25
Pfam CH 41 158
low_complexity n/a 57 67
coiled_coil n/a 165 192
disorder n/a 258 259
coiled_coil n/a 262 282
disorder n/a 270 276
disorder n/a 311 312
disorder n/a 324 325
low_complexity n/a 469 480
Pfam IQ 691 711
Pfam IQ 721 741
low_complexity n/a 800 812
coiled_coil n/a 804 824
disorder n/a 857 859
disorder n/a 873 874
Pfam RasGAP 938 1150
low_complexity n/a 1236 1246
disorder n/a 1252 1270
disorder n/a 1319 1366
Pfam RasGAP_C 1367 1499
disorder n/a 1371 1385
coiled_coil n/a 1411 1438
disorder n/a 1460 1469

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13576. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW
50
51
MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY
100
101
KKSGLHFRHT DNTVQWLRAM ESIGLPKIFY PETTDVYDRK NIPRMIYCIH
150
151
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPSFSKIG
200
201
GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP NAVLTLVDDN
250
251
LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK
300
301
VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN
350
351
LQKQNTMNYL AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG
400
401
LNNLDKAYVE RYANTLLSVK LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE
450
451
NDRVVAVGYI NEAIDEGNPL RTLETLLLPT ANISDVDPAH AQHYQDVLYH
500
501
AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT LVVDVNQCLE
550
551
GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW
600
601
LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG
650
651
YIRENIWSAS EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF
700
701
WKGYKQRKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH
750
751
NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE
800
801
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHSK
850
851
KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA
900
901
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK
950
951
VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII
1000
1001
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN
1050
1051
LRRVTDKVLN SIISSLDLLP YGLRYIAKVL KNSIHEKFPD ATEDELLKIV
1100
1101
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS VAKVLQHAAS
1150
1151
NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL
1200
1201
VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV
1250
1251
ESFLGEGAVD PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM
1300
1301
IKTKKLIIDV IRNQPGNTLT EILETPATAQ QEVDHATDMV SRAMIDSRTP
1350
1351
EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT LEQTGHVSSE NKYQDILNEI
1400
1401
AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN YYDTYIKTCL
1450
1451
DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT
1500
1501
NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV
1550
1551
MKMFDKVKVN VNLLIYLLNK KFYGK                           
1575
 

Show the unformatted sequence.

Checksums:
CRC64:BCC8CED6645CB09B
MD5:e43bdb4cee3cd521857ff2c154b5421f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RasGAP 938 - 1150 5CJP E 938 - 1150 Show 3D Structure View in InterPro
F 938 - 1150 Show 3D Structure View in InterPro
RasGAP_C 1477 - 1499 3IEZ A 1477 - 1499 Show 3D Structure View in InterPro
B 1477 - 1499 Show 3D Structure View in InterPro
4EZA A 2 - 24 Show 3D Structure View in InterPro
B 2 - 24 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;