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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ASPP2_HUMAN (Q13625)

Summary

This is the summary of UniProt entry ASPP2_HUMAN (Q13625).

Description: Apoptosis-stimulating of p53 protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1128 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 61 64
disorder n/a 77 78
disorder n/a 80 137
coiled_coil n/a 128 203
low_complexity n/a 138 147
disorder n/a 140 146
low_complexity n/a 154 177
disorder n/a 160 164
disorder n/a 169 178
disorder n/a 193 198
disorder n/a 207 208
coiled_coil n/a 207 241
disorder n/a 243 263
coiled_coil n/a 260 294
disorder n/a 277 279
disorder n/a 281 293
disorder n/a 295 301
coiled_coil n/a 305 325
disorder n/a 311 313
disorder n/a 315 316
disorder n/a 319 321
disorder n/a 323 602
low_complexity n/a 490 507
disorder n/a 605 758
disorder n/a 760 915
low_complexity n/a 769 786
low_complexity n/a 840 856
low_complexity n/a 864 884
Pfam Ank_3 958 987
Pfam Ank 991 1023
Pfam SH3_1 1063 1111

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13625. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MMPMFLTVYL SNNEQHFTEV PVTPETICRD VVDLCKEPGE SDCHLAEVWC
50
51
GSERPVADNE RMFDVLQRFG SQRNEVRFFL RHERPPGRDI VSGPRSQDPS
100
101
LKRNGVKVPG EYRRKENGVN SPRMDLTLAE LQEMASRQQQ QIEAQQQLLA
150
151
TKEQRLKFLK QQDQRQQQQV AEQEKLKRLK EIAENQEAKL KKVRALKGHV
200
201
EQKRLSNGKL VEEIEQMNNL FQQKQRELVL AVSKVEELTR QLEMLKNGRI
250
251
DSHHDNQSAV AELDRLYKEL QLRNKLNQEQ NAKLQQQREC LNKRNSEVAV
300
301
MDKRVNELRD RLWKKKAALQ QKENLPVSSD GNLPQQAASA PSRVAAVGPY
350
351
IQSSTMPRMP SRPELLVKPA LPDGSLVIQA SEGPMKIQTL PNMRSGAASQ
400
401
TKGSKIHPVG PDWSPSNADL FPSQGSASVP QSTGNALDQV DDGEVPLREK
450
451
EKKVRPFSMF DAVDQSNAPP SFGTLRKNQS SEDILRDAQV ANKNVAKVPP
500
501
PVPTKPKQIN LPYFGQTNQP PSDIKPDGSS QQLSTVVPSM GTKPKPAGQQ
550
551
PRVLLSPSIP SVGQDQTLSP GSKQESPPAA AVRPFTPQPS KDTLLPPFRK
600
601
PQTVAASSIY SMYTQQQAPG KNFQQAVQSA LTKTHTRGPH FSSVYGKPVI
650
651
AAAQNQQQHP ENIYSNSQGK PGSPEPETEP VSSVQENHEN ERIPRPLSPT
700
701
KLLPFLSNPY RNQSDADLEA LRKKLSNAPR PLKKRSSITE PEGPNGPNIQ
750
751
KLLYQRTTIA AMETISVPSY PSKSASVTAS SESPVEIQNP YLHVEPEKEV
800
801
VSLVPESLSP EDVGNASTEN SDMPAPSPGL DYEPEGVPDN SPNLQNNPEE
850
851
PNPEAPHVLD VYLEEYPPYP PPPYPSGEPE GPGEDSVSMR PPEITGQVSL
900
901
PPGKRTNLRK TGSERIAHGM RVKFNPLALL LDSSLEGEFD LVQRIIYEVD
950
951
DPSLPNDEGI TALHNAVCAG HTEIVKFLVQ FGVNVNAADS DGWTPLHCAA
1000
1001
SCNNVQVCKF LVESGAAVFA MTYSDMQTAA DKCEEMEEGY TQCSQFLYGV
1050
1051
QEKMGIMNKG VIYALWDYEP QNDDELPMKE GDCMTIIHRE DEDEIEWWWA
1100
1101
RLNDKEGYVP RNLLGLYPRI KPRQRSLA                        
1128
 

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Checksums:
CRC64:C75D056FBC1DAD75
MD5:5765b6e18f5a3d4e194043753b9aab74

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ank 991 - 1023 1YCS B 392 - 424 NGL View in InterPro
4A63 B 991 - 1023 NGL View in InterPro
D 991 - 1023 NGL View in InterPro
F 991 - 1023 NGL View in InterPro
H 991 - 1023 NGL View in InterPro
J 991 - 1023 NGL View in InterPro
L 991 - 1023 NGL View in InterPro
6GHM C 991 - 1023 NGL View in InterPro
D 991 - 1023 NGL View in InterPro
Ank_3 958 - 987 1YCS B 359 - 388 NGL View in InterPro
4A63 B 958 - 987 NGL View in InterPro
D 958 - 987 NGL View in InterPro
F 958 - 987 NGL View in InterPro
H 958 - 987 NGL View in InterPro
J 958 - 987 NGL View in InterPro
L 958 - 987 NGL View in InterPro
6GHM C 958 - 987 NGL View in InterPro
D 958 - 987 NGL View in InterPro
975 - 987 6HKP S 975 - 987 NGL View in InterPro
SH3_1 1063 - 1111 1YCS B 464 - 512 NGL View in InterPro
4A63 B 1063 - 1111 NGL View in InterPro
D 1063 - 1111 NGL View in InterPro
F 1063 - 1111 NGL View in InterPro
H 1063 - 1111 NGL View in InterPro
J 1063 - 1111 NGL View in InterPro
L 1063 - 1111 NGL View in InterPro
6GHM C 1063 - 1111 NGL View in InterPro
D 1063 - 1111 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.