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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FHL3_HUMAN (Q13643)

Summary

This is the summary of UniProt entry FHL3_HUMAN (Q13643).

Description: Four and a half LIM domains protein 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 280 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam LIM 40 97
Pfam LIM 101 158
Pfam LIM 162 217
Pfam LIM 221 279

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13643. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD
50
51
SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ
100
101
CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC
150
151
VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CQTPLAGQQF
200
201
TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE DRHWHHNCFS
250
251
CARCSTSLVG QGFVPDGDQV LCQGCSQAGP                      
280
 

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Checksums:
CRC64:D1A037C260370DFD
MD5:3adcc5f92d30d19535f1e861fc26ebc6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LIM 101 - 158 1WYH A 8 - 65 Jmol OpenAstexViewer
152 - 158 2CUQ A 8 - 14 Jmol OpenAstexViewer
162 - 217 2CUQ A 18 - 73 Jmol OpenAstexViewer
40 - 97 2EHE A 18 - 75 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.