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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KGP1_HUMAN (Q13976)

Summary

This is the summary of UniProt entry KGP1_HUMAN (Q13976).

Description: cGMP-dependent protein kinase 1 EC=2.7.11.12
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 671 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 9 39
Pfam PKcGMP_CC 10 44
coiled_coil n/a 12 46
disorder n/a 51 52
disorder n/a 56 62
Pfam cNMP_binding 121 204
Pfam cNMP_binding 239 327
low_complexity n/a 333 352
Pfam Pkinase 360 619
low_complexity n/a 502 513
low_complexity n/a 580 593
disorder n/a 605 606
disorder n/a 635 640
disorder n/a 643 670
low_complexity n/a 648 664

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13976. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSELEEDFAK ILMLKEERIK ELEKRLSEKE EEIQELKRKL HKCQSVLPVP
50
51
STHIGPRTTR AQGISAEPQT YRSFHDLRQA FRKFTKSERS KDLIKEAILD
100
101
NDFMKNLELS QIQEIVDCMY PVEYGKDSCI IKEGDVGSLV YVMEDGKVEV
150
151
TKEGVKLCTM GPGKVFGELA ILYNCTRTAT VKTLVNVKLW AIDRQCFQTI
200
201
MMRTGLIKHT EYMEFLKSVP TFQSLPEEIL SKLADVLEET HYENGEYIIR
250
251
QGARGDTFFI ISKGTVNVTR EDSPSEDPVF LRTLGKGDWF GEKALQGEDV
300
301
RTANVIAAEA VTCLVIDRDS FKHLIGGLDD VSNKAYEDAE AKAKYEAEAA
350
351
FFANLKLSDF NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT
400
401
RQQEHIRSEK QIMQGAHSDF IVRLYRTFKD SKYLYMLMEA CLGGELWTIL
450
451
RDRGSFEDST TRFYTACVVE AFAYLHSKGI IYRDLKPENL ILDHRGYAKL
500
501
VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD YWSLGILMYE
550
551
LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS
600
601
ERLGNLKNGV KDIQKHKWFE GFNWEGLRKG TLTPPIIPSV ASPTDTSNFD
650
651
SFPEDNDEPP PDDNSGWDID F                               
671
 

Show the unformatted sequence.

Checksums:
CRC64:51389502A5E5FBD2
MD5:e13d4905ae105519cb314d29bda73ee9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
cNMP_binding 121 - 202 4Z07 E 136 - 217 Jmol OpenAstexViewer
121 - 203 3OCP A 136 - 218 Jmol OpenAstexViewer
3OD0 A 136 - 218 Jmol OpenAstexViewer
B 136 - 218 Jmol OpenAstexViewer
3OGJ B 136 - 218 Jmol OpenAstexViewer
C 136 - 218 Jmol OpenAstexViewer
D 136 - 218 Jmol OpenAstexViewer
121 - 204 3OCP B 136 - 219 Jmol OpenAstexViewer
3OGJ A 136 - 219 Jmol OpenAstexViewer
4Z07 A 136 - 219 Jmol OpenAstexViewer
C 136 - 219 Jmol OpenAstexViewer
239 - 323 4KU8 B 254 - 338 Jmol OpenAstexViewer
239 - 327 4KU7 A 254 - 342 Jmol OpenAstexViewer
4KU8 A 254 - 342 Jmol OpenAstexViewer
C 254 - 342 Jmol OpenAstexViewer
4QX5 A 254 - 342 Jmol OpenAstexViewer
4QXK A 254 - 342 Jmol OpenAstexViewer
4Z07 A 254 - 342 Jmol OpenAstexViewer
C 254 - 342 Jmol OpenAstexViewer
5J48 A 254 - 342 Jmol OpenAstexViewer
B 254 - 342 Jmol OpenAstexViewer
5JAX A 254 - 342 Jmol OpenAstexViewer
5JD7 A 254 - 342 Jmol OpenAstexViewer
5L0N A 254 - 342 Jmol OpenAstexViewer
PKcGMP_CC 10 - 44 1ZXA A 10 - 44 Jmol OpenAstexViewer
B 10 - 44 Jmol OpenAstexViewer
3NMD A 17 - 50 Jmol OpenAstexViewer
B 17 - 50 Jmol OpenAstexViewer
C 17 - 50 Jmol OpenAstexViewer
D 17 - 50 Jmol OpenAstexViewer
E 17 - 50 Jmol OpenAstexViewer
4R4L A 9 - 43 Jmol OpenAstexViewer
B 9 - 43 Jmol OpenAstexViewer
C 9 - 43 Jmol OpenAstexViewer
4R4M A 9 - 43 Jmol OpenAstexViewer
B 9 - 43 Jmol OpenAstexViewer
C 9 - 43 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.