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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DAG1_HUMAN (Q14118)

Summary

This is the summary of UniProt entry DAG1_HUMAN (Q14118).

Description: Dystroglycan
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 895 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 27
low_complexity n/a 7 23
disorder n/a 36 38
Pfam He_PIG 61 156
disorder n/a 163 171
disorder n/a 175 179
Pfam a_DG1_N2 182 304
disorder n/a 271 280
disorder n/a 305 503
low_complexity n/a 340 353
low_complexity n/a 413 434
low_complexity n/a 430 467
low_complexity n/a 528 540
disorder n/a 535 537
Pfam DAG1 606 895
disorder n/a 677 680
disorder n/a 692 693
disorder n/a 727 747
transmembrane n/a 749 775
low_complexity n/a 754 771
disorder n/a 802 807
low_complexity n/a 807 816
disorder n/a 809 895
low_complexity n/a 858 872
low_complexity n/a 885 895

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14118. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRMSVGLSLL LPLSGRTFLL LLSVVMAQSH WPSEPSEAVR DWENQLEASM
50
51
HSVLSDLHEA VPTVVGIPDG TAVVGRSFRV TIPTDLIASS GDIIKVSAAG
100
101
KEALPSWLHW DSQSHTLEGL PLDTDKGVHY ISVSATRLGA NGSHIPQTSS
150
151
VFSIEVYPED HSELQSVRTA SPDPGEVVSS ACAADEPVTV LTVILDADLT
200
201
KMTPKQRIDL LHRMRSFSEV ELHNMKLVPV VNNRLFDMSA FMAGPGNAKK
250
251
VVENGALLSW KLGCSLNQNS VPDIHGVEAP AREGAMSAQL GYPVVGWHIA
300
301
NKKPPLPKRV RRQIHATPTP VTAIGPPTTA IQEPPSRIVP TPTSPAIAPP
350
351
TETMAPPVRD PVPGKPTVTI RTRGAIIQTP TLGPIQPTRV SEAGTTVPGQ
400
401
IRPTMTIPGY VEPTAVATPP TTTTKKPRVS TPKPATPSTD STTTTTRRPT
450
451
KKPRTPRPVP RVTTKVSITR LETASPPTRI RTTTSGVPRG GEPNQRPELK
500
501
NHIDRVDAWV GTYFEVKIPS DTFYDHEDTT TDKLKLTLKL REQQLVGEKS
550
551
WVQFNSNSQL MYGLPDSSHV GKHEYFMHAT DKGGLSAVDA FEIHVHRRPQ
600
601
GDRAPARFKA KFVGDPALVL NDIHKKIALV KKLAFAFGDR NCSTITLQNI
650
651
TRGSIVVEWT NNTLPLEPCP KEQIAGLSRR IAEDDGKPRP AFSNALEPDF
700
701
KATSITVTGS GSCRHLQFIP VVPPRRVPSE APPTEVPDRD PEKSSEDDVY
750
751
LHTVIPAVVV AAILLIAGII AMICYRKKRK GKLTLEDQAT FIKKGVPIIF
800
801
ADELDDSKPP PSSSMPLILQ EEKAPLPPPE YPNQSVPETT PLNQDTMGEY
850
851
TPLRDEDPNA PPYQPPPPFT APMEGKGSRP KNMTPYRSPP PYVPP     
895
 

Show the unformatted sequence.

Checksums:
CRC64:3AF6CBB0DCF91962
MD5:3a34e973828f33ca932422cd0f4eb99c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
a_DG1_N2 182 - 304 5LLK A 182 - 304 Show 3D Structure View in InterPro
DAG1 879 - 895 6JJY U 879 - 895 Show 3D Structure View in InterPro
882 - 894 1EG4 P 2 - 14 Show 3D Structure View in InterPro
He_PIG 61 - 156 5LLK A 61 - 156 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;