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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DSG2_HUMAN (Q14126)

Summary

This is the summary of UniProt entry DSG2_HUMAN (Q14126).

Description: Desmoglein-2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1118 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 23
Pfam Cadherin 164 263
disorder n/a 223 225
disorder n/a 232 244
disorder n/a 246 250
Pfam Cadherin 278 378
low_complexity n/a 367 383
Pfam Cadherin 396 490
transmembrane n/a 607 633
low_complexity n/a 612 634
disorder n/a 653 660
disorder n/a 665 670
low_complexity n/a 678 689
disorder n/a 692 693
disorder n/a 698 713
disorder n/a 715 720
disorder n/a 722 723
low_complexity n/a 733 753
disorder n/a 735 755
disorder n/a 794 795
disorder n/a 850 876
disorder n/a 881 890
disorder n/a 893 895
disorder n/a 898 941
disorder n/a 944 956
disorder n/a 973 974
disorder n/a 979 980
disorder n/a 985 1011
disorder n/a 1014 1015
disorder n/a 1020 1021
disorder n/a 1025 1028
disorder n/a 1033 1038
disorder n/a 1055 1118

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14126. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA
50
51
WITAPVALRE GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG
100
101
IFVFNKDTGE LNVTSILDRE ETPFFLLTGY ALDARGNNVE KPLELRIKVL
150
151
DINDNEPVFT QDVFVGSVEE LSAAHTLVMK INATDADEPN TLNSKISYRI
200
201
VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE ARDGNGEVTD
250
251
KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE
300
301
IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF
350
351
SVIVANKAAF HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES
400
401
MDRSSKGQII GNFQAFDEDT GLPAHARYVK LEDRDNWISV DSVTSEIKLA
450
451
KLPDFESRYV QNGTYTVKIV AISEDYPRKT ITGTVLINVE DINDNCPTLI
500
501
EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM AEKWKIARQE
550
551
STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR
600
601
EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT
650
651
IEMLHPWNNE GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS
700
701
SASIVKGQHE MSEMDGRWEE HRSLLSGRAT QFTGATGAIM TTETTKTARA
750
751
TGASRDMAGA QAAAVALNEE FLRNYFTDKA ASYTEEDENH TAKDCLLVYS
800
801
QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC LGQKIDINKE
850
851
IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE
900
901
KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT
950
951
VILGPSQPQS LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN
1000
1001
PLEGTQHLQD VPYVMVRERE SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV
1050
1051
LAPASTLQSS YQIPTENSMT ARNTTVSGAG VPGPLPDFGL EESGHSNSTI
1100
1101
TTSSTRVTKH STVQHSYS                                   
1118
 

Show the unformatted sequence.

Checksums:
CRC64:E1481AA1686DB80A
MD5:02c72f9fe7065c9487a6d0a68ffc5704

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cadherin 164 - 263 5ERD A 115 - 214 Show 3D Structure View in InterPro
B 115 - 214 Show 3D Structure View in InterPro
5J5J A 113 - 212 Show 3D Structure View in InterPro
6QNT D 115 - 214 Show 3D Structure View in InterPro
6QNU D 115 - 214 Show 3D Structure View in InterPro
E 115 - 214 Show 3D Structure View in InterPro
6SIT D 115 - 214 Show 3D Structure View in InterPro
7A7D A 115 - 214 Show 3D Structure View in InterPro
B 1813 - 1912 Show 3D Structure View in InterPro
C 681 - 780 Show 3D Structure View in InterPro
D 1247 - 1346 Show 3D Structure View in InterPro
E 1813 - 1912 Show 3D Structure View in InterPro
F 1247 - 1346 Show 3D Structure View in InterPro
G 681 - 780 Show 3D Structure View in InterPro
7AGF D 115 - 214 Show 3D Structure View in InterPro
E 115 - 214 Show 3D Structure View in InterPro
F 115 - 214 Show 3D Structure View in InterPro
7AGG D 115 - 214 Show 3D Structure View in InterPro
F 115 - 214 Show 3D Structure View in InterPro
278 - 378 5ERD A 229 - 329 Show 3D Structure View in InterPro
B 229 - 329 Show 3D Structure View in InterPro
5J5J A 227 - 327 Show 3D Structure View in InterPro
6QNT D 229 - 329 Show 3D Structure View in InterPro
6QNU D 229 - 329 Show 3D Structure View in InterPro
E 229 - 329 Show 3D Structure View in InterPro
6SIT D 229 - 329 Show 3D Structure View in InterPro
7A7D A 229 - 329 Show 3D Structure View in InterPro
B 1927 - 2027 Show 3D Structure View in InterPro
C 795 - 895 Show 3D Structure View in InterPro
D 1361 - 1461 Show 3D Structure View in InterPro
E 1927 - 2027 Show 3D Structure View in InterPro
F 1361 - 1461 Show 3D Structure View in InterPro
G 795 - 895 Show 3D Structure View in InterPro
7AGF D 229 - 329 Show 3D Structure View in InterPro
E 229 - 329 Show 3D Structure View in InterPro
F 229 - 329 Show 3D Structure View in InterPro
7AGG D 229 - 329 Show 3D Structure View in InterPro
F 229 - 329 Show 3D Structure View in InterPro
396 - 490 5ERD A 347 - 441 Show 3D Structure View in InterPro
B 347 - 441 Show 3D Structure View in InterPro
5J5J A 345 - 439 Show 3D Structure View in InterPro
7A7D A 347 - 441 Show 3D Structure View in InterPro
B 2045 - 2139 Show 3D Structure View in InterPro
C 913 - 1007 Show 3D Structure View in InterPro
D 1479 - 1573 Show 3D Structure View in InterPro
E 2045 - 2139 Show 3D Structure View in InterPro
F 1479 - 1573 Show 3D Structure View in InterPro
G 913 - 1007 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;