Summary
This is the summary of UniProt entry DSG2_HUMAN (Q14126).
| Description: | Desmoglein-2 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 1118 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 23 |
| Pfam | Cadherin | 164 | 263 |
| disorder | n/a | 223 | 225 |
| disorder | n/a | 232 | 244 |
| disorder | n/a | 246 | 250 |
| Pfam | Cadherin | 278 | 378 |
| low_complexity | n/a | 366 | 382 |
| Pfam | Cadherin | 396 | 490 |
| transmembrane | n/a | 607 | 633 |
| low_complexity | n/a | 611 | 633 |
| disorder | n/a | 653 | 660 |
| disorder | n/a | 665 | 670 |
| low_complexity | n/a | 677 | 688 |
| disorder | n/a | 692 | 693 |
| disorder | n/a | 698 | 713 |
| disorder | n/a | 715 | 720 |
| disorder | n/a | 722 | 723 |
| low_complexity | n/a | 732 | 752 |
| disorder | n/a | 735 | 755 |
| disorder | n/a | 794 | 795 |
| disorder | n/a | 850 | 876 |
| disorder | n/a | 881 | 890 |
| disorder | n/a | 893 | 895 |
| disorder | n/a | 898 | 941 |
| disorder | n/a | 944 | 956 |
| disorder | n/a | 973 | 974 |
| disorder | n/a | 979 | 980 |
| disorder | n/a | 985 | 1011 |
| disorder | n/a | 1014 | 1015 |
| disorder | n/a | 1020 | 1021 |
| disorder | n/a | 1025 | 1028 |
| disorder | n/a | 1033 | 1038 |
| disorder | n/a | 1055 | 1118 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q14126. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA
50 51
WITAPVALRE GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG
100 101
IFVFNKDTGE LNVTSILDRE ETPFFLLTGY ALDARGNNVE KPLELRIKVL
150 151
DINDNEPVFT QDVFVGSVEE LSAAHTLVMK INATDADEPN TLNSKISYRI
200 201
VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE ARDGNGEVTD
250 251
KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE
300 301
IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF
350 351
SVIVANKAAF HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES
400 401
MDRSSKGQII GNFQAFDEDT GLPAHARYVK LEDRDNWISV DSVTSEIKLA
450 451
KLPDFESRYV QNGTYTVKIV AISEDYPRKT ITGTVLINVE DINDNCPTLI
500 501
EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM AEKWKIARQE
550 551
STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR
600 601
EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT
650 651
IEMLHPWNNE GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS
700 701
SASIVKGQHE MSEMDGRWEE HRSLLSGRAT QFTGATGAIM TTETTKTARA
750 751
TGASRDMAGA QAAAVALNEE FLRNYFTDKA ASYTEEDENH TAKDCLLVYS
800 801
QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC LGQKIDINKE
850 851
IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE
900 901
KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT
950 951
VILGPSQPQS LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN
1000 1001
PLEGTQHLQD VPYVMVRERE SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV
1050 1051
LAPASTLQSS YQIPTENSMT ARNTTVSGAG VPGPLPDFGL EESGHSNSTI
1100 1101
TTSSTRVTKH STVQHSYS
1118
Show the unformatted sequence. |
| Checksums: |
CRC64:E1481AA1686DB80A
MD5:02c72f9fe7065c9487a6d0a68ffc5704
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Cadherin | 164 - 263 | 5ERD | A | 115 - 214 | Jmol OpenAstexViewer |
| B | 115 - 214 | Jmol OpenAstexViewer | |||
| 5J5J | A | 113 - 212 | Jmol OpenAstexViewer | ||
| 6QNT | D | 115 - 214 | Jmol OpenAstexViewer | ||
| 6QNU | D | 115 - 214 | Jmol OpenAstexViewer | ||
| E | 115 - 214 | Jmol OpenAstexViewer | |||
| 278 - 378 | 5ERD | A | 229 - 329 | Jmol OpenAstexViewer | |
| B | 229 - 329 | Jmol OpenAstexViewer | |||
| 5J5J | A | 227 - 327 | Jmol OpenAstexViewer | ||
| 6QNT | D | 229 - 329 | Jmol OpenAstexViewer | ||
| 6QNU | D | 229 - 329 | Jmol OpenAstexViewer | ||
| E | 229 - 329 | Jmol OpenAstexViewer | |||
| 396 - 490 | 5ERD | A | 347 - 441 | Jmol OpenAstexViewer | |
| B | 347 - 441 | Jmol OpenAstexViewer | |||
| 5J5J | A | 345 - 439 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
