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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MORC3_HUMAN (Q14149)

Summary

This is the summary of UniProt entry MORC3_HUMAN (Q14149).

Description: MORC family CW-type zinc finger protein 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 939 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam HATPase_c_3 26 164
Pfam Morc6_S5 249 382
disorder n/a 397 398
Pfam zf-CW 409 452
disorder n/a 430 431
disorder n/a 433 434
disorder n/a 444 464
low_complexity n/a 447 458
low_complexity n/a 461 473
disorder n/a 468 470
disorder n/a 472 478
disorder n/a 487 489
disorder n/a 495 557
disorder n/a 559 568
disorder n/a 570 655
low_complexity n/a 571 576
low_complexity n/a 603 614
low_complexity n/a 624 630
disorder n/a 672 692
coiled_coil n/a 689 730
disorder n/a 755 758
disorder n/a 765 775
coiled_coil n/a 770 793
disorder n/a 800 802
coiled_coil n/a 823 871
disorder n/a 858 885

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14149. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAQPPRGIR LSALCPKFLH TNSTSHTWPF SAVAELIDNA YDPDVNAKQI
50
51
WIDKTVINDH ICLTFTDNGN GMTSDKLHKM LSFGFSDKVT MNGHVPVGLY
100
101
GNGFKSGSMR LGKDAIVFTK NGESMSVGLL SQTYLEVIKA EHVVVPIVAF
150
151
NKHRQMINLA ESKASLAAIL EHSLFSTEQK LLAELDAIIG KKGTRIIIWN
200
201
LRSYKNATEF DFEKDKYDIR IPEDLDEITG KKGYKKQERM DQIAPESDYS
250
251
LRAYCSILYL KPRMQIILRG QKVKTQLVSK SLAYIERDVY RPKFLSKTVR
300
301
ITFGFNCRNK DHYGIMMYHR NRLIKAYEKV GCQLRANNMG VGVVGIIECN
350
351
FLKPTHNKQD FDYTNEYRLT ITALGEKLND YWNEMKVKKN TEYPLNLPVE
400
401
DIQKRPDQTW VQCDACLKWR KLPDGMDQLP EKWYCSNNPD PQFRNCEVPE
450
451
EPEDEDLVHP TYEKTYKKTN KEKFRIRQPE MIPRINAELL FRPTALSTPS
500
501
FSSPKESVPR RHLSEGTNSY ATRLLNNHQV PPQSEPESNS LKRRLSTRSS
550
551
ILNAKNRRLS SQFENSVYKG DDDDEDVIIL EENSTPKPAV DHDIDMKSEQ
600
601
SHVEQGGVQV EFVGDSEPCG QTGSTSTSSS RCDQGNTAAT QTEVPSLVVK
650
651
KEETVEDEID VRNDAVILPS CVEAEAKIHE TQETTDKSAD DAGCQLQELR
700
701
NQLLLVTEEK ENYKRQCHMF TDQIKVLQQR ILEMNDKYVK KETCHQSTET
750
751
DAVFLLESIN GKSESPDHMV SQYQQALEEI ERLKKQCSAL QHVKAECSQC
800
801
SNNESKSEMD EMAVQLDDVF RQLDKCSIER DQYKSEVELL EMEKSQIRSQ
850
851
CEELKTEVEQ LKSTNQQTAT DVSTSSNIEE SVNHMDGESL KLRSLRVNVG
900
901
QLLAMIVPDL DLQQVNYDVD VVDEILGQVV EQMSEISST            
939
 

Show the unformatted sequence.

Checksums:
CRC64:7DF0EC31936BF5FF
MD5:4f1a544315cca59957034c2d207a19bd

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HATPase_c_3 26 - 164 6O1E A 26 - 164 Show 3D Structure View in InterPro
Morc6_S5 249 - 382 6O1E A 249 - 382 Show 3D Structure View in InterPro
zf-CW 409 - 452 4QQ4 A 409 - 452 Show 3D Structure View in InterPro
B 409 - 452 Show 3D Structure View in InterPro
5SVI A 409 - 452 Show 3D Structure View in InterPro
B 3 - 46 Show 3D Structure View in InterPro
5SVX A 3 - 46 Show 3D Structure View in InterPro
5SVY A 409 - 452 Show 3D Structure View in InterPro
6O1E A 409 - 452 Show 3D Structure View in InterPro
6O5W A 409 - 452 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;