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20  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCRIB_HUMAN (Q14160)

Summary

This is the summary of UniProt entry SCRIB_HUMAN (Q14160).

Description: Protein scribble homolog
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1630 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam LRR_8 36 94
low_complexity n/a 239 258
disorder n/a 396 401
disorder n/a 409 439
disorder n/a 447 704
low_complexity n/a 457 466
low_complexity n/a 532 546
low_complexity n/a 550 563
low_complexity n/a 660 695
coiled_coil n/a 672 695
disorder n/a 709 710
disorder n/a 714 720
low_complexity n/a 722 732
disorder n/a 726 730
Pfam PDZ 728 812
disorder n/a 733 734
low_complexity n/a 736 748
disorder n/a 738 764
disorder n/a 773 774
disorder n/a 794 795
disorder n/a 797 799
disorder n/a 820 853
low_complexity n/a 835 858
disorder n/a 857 862
Pfam PDZ 863 947
disorder n/a 876 880
disorder n/a 929 930
disorder n/a 946 947
disorder n/a 949 975
low_complexity n/a 953 965
low_complexity n/a 962 979
disorder n/a 978 980
low_complexity n/a 984 996
Pfam PDZ 1004 1090
disorder n/a 1016 1019
disorder n/a 1022 1025
disorder n/a 1029 1030
disorder n/a 1099 1101
Pfam PDZ 1100 1189
disorder n/a 1114 1139
low_complexity n/a 1143 1158
disorder n/a 1222 1262
disorder n/a 1277 1630
low_complexity n/a 1295 1310
low_complexity n/a 1332 1349
coiled_coil n/a 1379 1413
low_complexity n/a 1404 1418
low_complexity n/a 1418 1434
low_complexity n/a 1445 1457
low_complexity n/a 1488 1505
low_complexity n/a 1539 1550
low_complexity n/a 1613 1630

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14160. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLKCIPLWRC NRHVESVDKR HCSLQAVPEE IYRYSRSLEE LLLDANQLRE
50
51
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES
100
101
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL
150
151
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR
200
201
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPAELG GLVLLTDLLL
250
251
SQNLLRRLPD GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
300
301
LMALPRSLGK LTKLTNLNVD RNHLEALPPE IGGCVALSVL SLRDNRLAVL
350
351
PPELAHTTEL HVLDVAGNRL QSLPFALTHL NLKALWLAEN QAQPMLRFQT
400
401
EDDARTGEKV LTCYLLPQQP PPSLEDAGQQ GSLSETWSDA PPSRVSVIQF
450
451
LEAPIGDEDA EEAAAEKRGL QRRATPHPSE LKVMKRSIEG RRSEACPCQP
500
501
DSGSPLPAEE EKRLSAESGL SEDSRPSAST VSEAEPEGPS AEAQGGSQQE
550
551
ATTAGGEEDA EEDYQEPTVH FAEDALLPGD DREIEEGQPE APWTLPGGRQ
600
601
RLIRKDTPHY KKHFKISKLP QPEAVVALLQ GMQPDGEGPV APGGWHNGPH
650
651
APWAPRAQKE EEEEEEGSPQ EEEVEEEEEN RAEEEEASTE EEDKEGAVVS
700
701
APSVKGVSFD QANNLLIEPA RIEEEELTLT ILRQTGGLGI SIAGGKGSTP
750
751
YKGDDEGIFI SRVSEEGPAA RAGVRVGDKL LEVNGVALQG AEHHEAVEAL
800
801
RGAGTAVQMR VWRERMVEPE NAVTITPLRP EDDYSPRERR GGGLRLPLLP
850
851
PESPGPLRQR HVACLARSER GLGFSIAGGK GSTPYRAGDA GIFVSRIAEG
900
901
GAAHRAGTLQ VGDRVLSING VDVTEARHDH AVSLLTAASP TIALLLEREA
950
951
GGPLPPSPLP HSSPPTAAVA TTSITTATPG VPGLPSLAPS LLAAALEGPY
1000
1001
PVEEIRLPRA GGPLGLSIVG GSDHSSHPFG VQEPGVFISK VLPRGLAARS
1050
1051
GLRVGDRILA VNGQDVRDAT HQEAVSALLR PCLELSLLVR RDPAPPGLRE
1100
1101
LCIQKAPGER LGISIRGGAR GHAGNPRDPT DEGIFISKVS PTGAAGRDGR
1150
1151
LRVGLRLLEV NQQSLLGLTH GEAVQLLRSV GDTLTVLVCD GFEASTDAAL
1200
1201
EVSPGVIANP FAAGIGHRNS LESISSIDRE LSPEGPGKEK ELPGQTLHWG
1250
1251
PEATEAAGRG LQPLKLDYRA LAAVPSAGSV QRVPSGAAGG KMAESPCSPS
1300
1301
GQQPPSPPSP DELPANVKQA YRAFAAVPTS HPPEDAPAQP PTPGPAASPE
1350
1351
QLSFRERQKY FELEVRVPQA EGPPKRVSLV GADDLRKMQE EEARKLQQKR
1400
1401
AQMLREAAEA GAEARLALDG ETLGEEEQED EQPPWASPSP TSRQSPASPP
1450
1451
PLGGGAPVRT AKAERRHQER LRVQSPEPPA PERALSPAEL RALEAEKRAL
1500
1501
WRAARMKSLE QDALRAQMVL SRSQEGRGTR GPLERLAEAP SPAPTPSPTP
1550
1551
VEDLGPQTST SPGRLSPDFA EELRSLEPSP SPGPQEEDGE VALVLLGRPS
1600
1601
PGAVGPEDVA LCSSRRPVRP GRRGLGPVPS                      
1630
 

Show the unformatted sequence.

Checksums:
CRC64:D71E024FBC4F72D1
MD5:191a43909d7b012f38806ec4e3c7bb56

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PDZ 1004 - 1090 4WYT A 14 - 100 Show 3D Structure View in InterPro
4WYU A 14 - 100 Show 3D Structure View in InterPro
B 14 - 100 Show 3D Structure View in InterPro
5VWI A 14 - 100 Show 3D Structure View in InterPro
B 14 - 100 Show 3D Structure View in InterPro
6XA6 A 1004 - 1090 Show 3D Structure View in InterPro
B 1004 - 1090 Show 3D Structure View in InterPro
1100 - 1189 1UJU A 12 - 101 Show 3D Structure View in InterPro
4WYT A 110 - 199 Show 3D Structure View in InterPro
4WYU A 110 - 199 Show 3D Structure View in InterPro
B 110 - 199 Show 3D Structure View in InterPro
6EEY A 1100 - 1189 Show 3D Structure View in InterPro
728 - 812 1X5Q A 18 - 102 Show 3D Structure View in InterPro
2W4F A 728 - 812 Show 3D Structure View in InterPro
5VWC A 728 - 812 Show 3D Structure View in InterPro
5VWK A 728 - 812 Show 3D Structure View in InterPro
B 728 - 812 Show 3D Structure View in InterPro
C 728 - 812 Show 3D Structure View in InterPro
D 728 - 812 Show 3D Structure View in InterPro
6ESP A 15 - 99 Show 3D Structure View in InterPro
6MS1 A 728 - 812 Show 3D Structure View in InterPro
B 728 - 812 Show 3D Structure View in InterPro
6MTU A 728 - 812 Show 3D Structure View in InterPro
B 728 - 812 Show 3D Structure View in InterPro
6MTV A 728 - 812 Show 3D Structure View in InterPro
B 728 - 812 Show 3D Structure View in InterPro
6MYE A 728 - 812 Show 3D Structure View in InterPro
6MYF A 728 - 812 Show 3D Structure View in InterPro
6XA8 A 728 - 812 Show 3D Structure View in InterPro
B 728 - 812 Show 3D Structure View in InterPro
863 - 947 1WHA A 11 - 95 Show 3D Structure View in InterPro
6XA7 A 863 - 947 Show 3D Structure View in InterPro
B 863 - 947 Show 3D Structure View in InterPro
C 863 - 947 Show 3D Structure View in InterPro
D 863 - 947 Show 3D Structure View in InterPro
7JO7 A 863 - 947 Show 3D Structure View in InterPro
B 863 - 947 Show 3D Structure View in InterPro
C 863 - 947 Show 3D Structure View in InterPro
D 863 - 947 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;