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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DPYL3_HUMAN (Q14195)

Summary

This is the summary of UniProt entry DPYL3_HUMAN (Q14195).

Description: Dihydropyrimidinase-related protein 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 570 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Amidohydro_1 64 453
disorder n/a 217 219
low_complexity n/a 302 314
disorder n/a 303 304
disorder n/a 313 314
disorder n/a 502 545
disorder n/a 549 570

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14195. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSYQGKKNIP RITSDRLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI
50
51
VPGGVKTIEA NGKMVIPGGI DVHTHFQMPY KGMTTVDDFF QGTKAALAGG
100
101
TTMIIDHVVP EPESSLTEAY EKWREWADGK SCCDYALHVD ITHWNDSVKQ
150
151
EVQNLIKDKG VNSFMVYMAY KDLYQVSNTE LYEIFTCLGE LGAIAQVHAE
200
201
NGDIIAQEQT RMLEMGITGP EGHVLSRPEE LEAEAVFRAI TIASQTNCPL
250
251
YVTKVMSKSA ADLISQARKK GNVVFGEPIT ASLGIDGTHY WSKNWAKAAA
300
301
FVTSPPLSPD PTTPDYINSL LASGDLQLSG SAHCTFSTAQ KAIGKDNFTA
350
351
IPEGTNGVEE RMSVIWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR
400
401
ISVGSDSDLV IWDPDAVKIV SAKNHQSAAE YNIFEGMELR GAPLVVICQG
450
451
KIMLEDGNLH VTQGAGRFIP CSPFSDYVYK RIKARRKMAD LHAVPRGMYD
500
501
GPVFDLTTTP KGGTPAGSAR GSPTRPNPPV RNLHQSGFSL SGTQVDEGVR
550
551
SASKRIVAPP GGRSNITSLS                                 
570
 

Show the unformatted sequence.

Checksums:
CRC64:9D6AFE86CBB33AD5
MD5:414fd79c3fbd3c2611f267c640ef5b00

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Amidohydro_1 64 - 453 4BKN A 64 - 453 Jmol OpenAstexViewer
B 64 - 453 Jmol OpenAstexViewer
4CNS A 64 - 453 Jmol OpenAstexViewer
B 64 - 453 Jmol OpenAstexViewer
C 64 - 453 Jmol OpenAstexViewer
D 64 - 453 Jmol OpenAstexViewer
4CNT A 64 - 453 Jmol OpenAstexViewer
B 64 - 453 Jmol OpenAstexViewer
C 64 - 453 Jmol OpenAstexViewer
D 64 - 453 Jmol OpenAstexViewer
4CNU A 64 - 453 Jmol OpenAstexViewer
B 64 - 453 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.