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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DCTN1_HUMAN (Q14203)

Summary

This is the summary of UniProt entry DCTN1_HUMAN (Q14203).

Description: Dynactin subunit 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1278 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 2 24
Pfam CAP_GLY 29 94
disorder n/a 29 34
disorder n/a 64 66
disorder n/a 72 76
disorder n/a 92 243
low_complexity n/a 134 155
low_complexity n/a 160 183
coiled_coil n/a 217 352
low_complexity n/a 226 239
low_complexity n/a 233 251
disorder n/a 245 251
disorder n/a 255 327
low_complexity n/a 273 291
disorder n/a 342 348
disorder n/a 353 362
coiled_coil n/a 360 383
disorder n/a 372 379
disorder n/a 381 382
disorder n/a 385 394
coiled_coil n/a 388 540
low_complexity n/a 399 415
disorder n/a 402 411
disorder n/a 413 431
disorder n/a 434 438
disorder n/a 441 449
disorder n/a 451 452
disorder n/a 454 491
disorder n/a 494 505
disorder n/a 507 508
Pfam Dynactin 527 805
disorder n/a 528 557
low_complexity n/a 836 856
low_complexity n/a 854 869
disorder n/a 907 929
coiled_coil n/a 952 1043
disorder n/a 986 1000
disorder n/a 1002 1011
disorder n/a 1016 1021
disorder n/a 1023 1025
disorder n/a 1030 1051
disorder n/a 1056 1063
disorder n/a 1067 1088
disorder n/a 1116 1119
disorder n/a 1125 1138
disorder n/a 1140 1147
disorder n/a 1166 1177
disorder n/a 1179 1184
coiled_coil n/a 1185 1205
disorder n/a 1204 1214
disorder n/a 1217 1219

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14203. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQSKRHVYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT
50
51
LFATGKWVGV ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG
100
101
ADTTSPETPD SSASKVLKRE GTDTTAKTSK LRGLKPKKAP TARKTTTRRP
150
151
KPTRPASTGV AGASSSLGPS GSASAGELSS SEPSTPAQTP LAAPIIPTPV
200
201
LTSPGAVPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRAE DKAKLKELEK
250
251
HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT
300
301
ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG
350
351
SDGAASSYQL KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ
400
401
ELEVVRQQRE RLQEELSQAE STIDELKEQV DAALGAEEMV EMLTDRNLNL
450
451
EEKVRELRET VGDLEAMNEM NDELQENARE TELELREQLD MAGARVREAQ
500
501
KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA SVERQQQPPP
550
551
ETFDFKIKFA ETKAHAKAIE MELRQMEVAQ ANRHMSLLTA FMPDSFLRPG
600
601
GDHDCVLVLL LMPRLICKAE LIRKQAQEKF ELSENCSERP GLRGAAGEQL
650
651
SFAAGLVYSL SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD
700
701
FLIELLHKDQ LDETVNVEPL TKAIKYYQHL YSIHLAEQPE DCTMQLADHI
750
751
KFTQSALDCM SVEVGRLRAF LQGGQEATDI ALLLRDLETS CSDIRQFCKK
800
801
IRRRMPGTDA PGIPAALAFG PQVSDTLLDC RKHLTWVVAV LQEVAAAAAQ
850
851
LIAPLAENEG LLVAALEELA FKASEQIYGT PSSSPYECLR QSCNILISTM
900
901
NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET
950
951
VIKELKKSLK IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLEE
1000
1001
TQALLRKKEK EFEETMDALQ ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG
1050
1051
PPPSGIATLV SGIAGEEQQR GAIPGQAPGS VPGPGLVKDS PLLLQQISAM
1100
1101
RLHISQLQHE NSILKGAQMK ASLASLPPLH VAKLSHEGPG SELPAGALYR
1150
1151
KTSQLLETLN QLSTHTHVVD ITRTSPAAKS PSAQLMEQVA QLKSLSDTVE
1200
1201
KLKDEVLKET VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF
1250
1251
SCAAGFGQRH RLVLTQEQLH QLHSRLIS                        
1278
 

Show the unformatted sequence.

Checksums:
CRC64:6DCEA5E67856E4BC
MD5:e6914f946787419b29213b1114d2773f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CAP_GLY 29 - 94 1TXQ A 29 - 94 Jmol OpenAstexViewer
2COY A 36 - 101 Jmol OpenAstexViewer
2HKN A 29 - 94 Jmol OpenAstexViewer
B 29 - 94 Jmol OpenAstexViewer
2HKQ B 29 - 94 Jmol OpenAstexViewer
2HL3 A 29 - 94 Jmol OpenAstexViewer
B 29 - 94 Jmol OpenAstexViewer
2HL5 C 29 - 94 Jmol OpenAstexViewer
D 29 - 94 Jmol OpenAstexViewer
2HQH A 29 - 94 Jmol OpenAstexViewer
B 29 - 94 Jmol OpenAstexViewer
C 29 - 94 Jmol OpenAstexViewer
D 29 - 94 Jmol OpenAstexViewer
3E2U A 29 - 94 Jmol OpenAstexViewer
B 29 - 94 Jmol OpenAstexViewer
C 29 - 94 Jmol OpenAstexViewer
D 29 - 94 Jmol OpenAstexViewer
3TQ7 P 29 - 94 Jmol OpenAstexViewer
Q 29 - 94 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.