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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DYHC1_HUMAN (Q14204)

Summary

This is the summary of UniProt entry DYHC1_HUMAN (Q14204).

Description: Cytoplasmic dynein 1 heavy chain 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 4646 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 17
low_complexity n/a 4 14
low_complexity n/a 39 62
disorder n/a 52 56
disorder n/a 80 87
low_complexity n/a 84 96
disorder n/a 89 91
disorder n/a 172 181
disorder n/a 228 229
disorder n/a 232 233
Pfam DHC_N1 242 832
disorder n/a 492 499
coiled_coil n/a 543 563
disorder n/a 937 950
disorder n/a 1153 1155
coiled_coil n/a 1173 1200
disorder n/a 1262 1265
Pfam DHC_N2 1319 1720
Pfam AAA_6 1868 2231
low_complexity n/a 2103 2117
disorder n/a 2109 2110
disorder n/a 2114 2115
disorder n/a 2121 2125
disorder n/a 2390 2410
low_complexity n/a 2395 2406
Pfam Dynein_AAA_lid 2423 2550
Pfam AAA_7 2557 2739
Pfam AAA_8 2907 3186
disorder n/a 3161 3165
disorder n/a 3198 3200
Pfam MT 3199 3536
coiled_coil n/a 3205 3253
disorder n/a 3235 3238
disorder n/a 3240 3248
disorder n/a 3251 3259
coiled_coil n/a 3402 3499
disorder n/a 3417 3425
disorder n/a 3427 3428
disorder n/a 3430 3432
Pfam AAA_9 3560 3780
coiled_coil n/a 3770 3790
disorder n/a 3971 3975
Pfam Dynein_heavy 4036 4153
Pfam AAA_lid_11 4154 4327
Pfam Dynein_C 4333 4644
disorder n/a 4356 4375

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14204. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSEPGGGGGE DGSAGLEVSA VQNVADVSVL QKHLRKLVPL LLEDGGEAPA
50
51
ALEAALEEKS ALEQMRKFLS DPQVHTVLVE RSTLKEDVGD EGEEEKEFIS
100
101
YNINIDIHYG VKSNSLAFIK RTPVIDADKP VSSQLRVLTL SEDSPYETLH
150
151
SFISNAVAPF FKSYIRESGK ADRDGDKMAP SVEKKIAELE MGLLHLQQNI
200
201
EIPEISLPIH PMITNVAKQC YERGEKPKVT DFGDKVEDPT FLNQLQSGVN
250
251
RWIREIQKVT KLDRDPASGT ALQEISFWLN LERALYRIQE KRESPEVLLT
300
301
LDILKHGKRF HATVSFDTDT GLKQALETVN DYNPLMKDFP LNDLLSATEL
350
351
DKIRQALVAI FTHLRKIRNT KYPIQRALRL VEAISRDLSS QLLKVLGTRK
400
401
LMHVAYEEFE KVMVACFEVF QTWDDEYEKL QVLLRDIVKR KREENLKMVW
450
451
RINPAHRKLQ ARLDQMRKFR RQHEQLRAVI VRVLRPQVTA VAQQNQGEVP
500
501
EPQDMKVAEV LFDAADANAI EEVNLAYENV KEVDGLDVSK EGTEAWEAAM
550
551
KRYDERIDRV ETRITARLRD QLGTAKNANE MFRIFSRFNA LFVRPHIRGA
600
601
IREYQTQLIQ RVKDDIESLH DKFKVQYPQS QACKMSHVRD LPPVSGSIIW
650
651
AKQIDRQLTA YMKRVEDVLG KGWENHVEGQ KLKQDGDSFR MKLNTQEIFD
700
701
DWARKVQQRN LGVSGRIFTI ESTRVRGRTG NVLKLKVNFL PEIITLSKEV
750
751
RNLKWLGFRV PLAIVNKAHQ ANQLYPFAIS LIESVRTYER TCEKVEERNT
800
801
ISLLVAGLKK EVQALIAEGI ALVWESYKLD PYVQRLAETV FNFQEKVDDL
850
851
LIIEEKIDLE VRSLETCMYD HKTFSEILNR VQKAVDDLNL HSYSNLPIWV
900
901
NKLDMEIERI LGVRLQAGLR AWTQVLLGQA EDKAEVDMDT DAPQVSHKPG
950
951
GEPKIKNVVH ELRITNQVIY LNPPIEECRY KLYQEMFAWK MVVLSLPRIQ
1000
1001
SQRYQVGVHY ELTEEEKFYR NALTRMPDGP VALEESYSAV MGIVSEVEQY
1050
1051
VKVWLQYQCL WDMQAENIYN RLGEDLNKWQ ALLVQIRKAR GTFDNAETKK
1100
1101
EFGPVVIDYG KVQSKVNLKY DSWHKEVLSK FGQMLGSNMT EFHSQISKSR
1150
1151
QELEQHSVDT ASTSDAVTFI TYVQSLKRKI KQFEKQVELY RNGQRLLEKQ
1200
1201
RFQFPPSWLY IDNIEGEWGA FNDIMRRKDS AIQQQVANLQ MKIVQEDRAV
1250
1251
ESRTTDLLTD WEKTKPVTGN LRPEEALQAL TIYEGKFGRL KDDREKCAKA
1300
1301
KEALELTDTG LLSGSEERVQ VALEELQDLK GVWSELSKVW EQIDQMKEQP
1350
1351
WVSVQPRKLR QNLDALLNQL KSFPARLRQY ASYEFVQRLL KGYMKINMLV
1400
1401
IELKSEALKD RHWKQLMKRL HVNWVVSELT LGQIWDVDLQ KNEAIVKDVL
1450
1451
LVAQGEMALE EFLKQIREVW NTYELDLVNY QNKCRLIRGW DDLFNKVKEH
1500
1501
INSVSAMKLS PYYKVFEEDA LSWEDKLNRI MALFDVWIDV QRRWVYLEGI
1550
1551
FTGSADIKHL LPVETQRFQS ISTEFLALMK KVSKSPLVMD VLNIQGVQRS
1600
1601
LERLADLLGK IQKALGEYLE RERSSFPRFY FVGDEDLLEI IGNSKNVAKL
1650
1651
QKHFKKMFAG VSSIILNEDN SVVLGISSRE GEEVMFKTPV SITEHPKINE
1700
1701
WLTLVEKEMR VTLAKLLAES VTEVEIFGKA TSIDPNTYIT WIDKYQAQLV
1750
1751
VLSAQIAWSE NVETALSSMG GGGDAAPLHS VLSNVEVTLN VLADSVLMEQ
1800
1801
PPLRRRKLEH LITELVHQRD VTRSLIKSKI DNAKSFEWLS QMRFYFDPKQ
1850
1851
TDVLQQLSIQ MANAKFNYGF EYLGVQDKLV QTPLTDRCYL TMTQALEARL
1900
1901
GGSPFGPAGT GKTESVKALG HQLGRFVLVF NCDETFDFQA MGRIFVGLCQ
1950
1951
VGAWGCFDEF NRLEERMLSA VSQQVQCIQE ALREHSNPNY DKTSAPITCE
2000
2001
LLNKQVKVSP DMAIFITMNP GYAGRSNLPD NLKKLFRSLA MTKPDRQLIA
2050
2051
QVMLYSQGFR TAEVLANKIV PFFKLCDEQL SSQSHYDFGL RALKSVLVSA
2100
2101
GNVKRERIQK IKREKEERGE AVDEGEIAEN LPEQEILIQS VCETMVPKLV
2150
2151
AEDIPLLFSL LSDVFPGVQY HRGEMTALRE ELKKVCQEMY LTYGDGEEVG
2200
2201
GMWVEKVLQL YQITQINHGL MMVGPSGSGK SMAWRVLLKA LERLEGVEGV
2250
2251
AHIIDPKAIS KDHLYGTLDP NTREWTDGLF THVLRKIIDS VRGELQKRQW
2300
2301
IVFDGDVDPE WVENLNSVLD DNKLLTLPNG ERLSLPPNVR IMFEVQDLKY
2350
2351
ATLATVSRCG MVWFSEDVLS TDMIFNNFLA RLRSIPLDEG EDEAQRRRKG
2400
2401
KEDEGEEAAS PMLQIQRDAA TIMQPYFTSN GLVTKALEHA FQLEHIMDLT
2450
2451
RLRCLGSLFS MLHQACRNVA QYNANHPDFP MQIEQLERYI QRYLVYAILW
2500
2501
SLSGDSRLKM RAELGEYIRR ITTVPLPTAP NIPIIDYEVS ISGEWSPWQA
2550
2551
KVPQIEVETH KVAAPDVVVP TLDTVRHEAL LYTWLAEHKP LVLCGPPGSG
2600
2601
KTMTLFSALR ALPDMEVVGL NFSSATTPEL LLKTFDHYCE YRRTPNGVVL
2650
2651
APVQLGKWLV LFCDEINLPD MDKYGTQRVI SFIRQMVEHG GFYRTSDQTW
2700
2701
VKLERIQFVG ACNPPTDPGR KPLSHRFLRH VPVVYVDYPG PASLTQIYGT
2750
2751
FNRAMLRLIP SLRTYAEPLT AAMVEFYTMS QERFTQDTQP HYIYSPREMT
2800
2801
RWVRGIFEAL RPLETLPVEG LIRIWAHEAL RLFQDRLVED EERRWTDENI
2850
2851
DTVALKHFPN IDREKAMSRP ILYSNWLSKD YIPVDQEELR DYVKARLKVF
2900
2901
YEEELDVPLV LFNEVLDHVL RIDRIFRQPQ GHLLLIGVSG AGKTTLSRFV
2950
2951
AWMNGLSVYQ IKVHRKYTGE DFDEDLRTVL RRSGCKNEKI AFIMDESNVL
3000
3001
DSGFLERMNT LLANGEVPGL FEGDEYATLM TQCKEGAQKE GLMLDSHEEL
3050
3051
YKWFTSQVIR NLHVVFTMNP SSEGLKDRAA TSPALFNRCV LNWFGDWSTE
3100
3101
ALYQVGKEFT SKMDLEKPNY IVPDYMPVVY DKLPQPPSHR EAIVNSCVFV
3150
3151
HQTLHQANAR LAKRGGRTMA ITPRHYLDFI NHYANLFHEK RSELEEQQMH
3200
3201
LNVGLRKIKE TVDQVEELRR DLRIKSQELE VKNAAANDKL KKMVKDQQEA
3250
3251
EKKKVMSQEI QEQLHKQQEV IADKQMSVKE DLDKVEPAVI EAQNAVKSIK
3300
3301
KQHLVEVRSM ANPPAAVKLA LESICLLLGE STTDWKQIRS IIMRENFIPT
3350
3351
IVNFSAEEIS DAIREKMKKN YMSNPSYNYE IVNRASLACG PMVKWAIAQL
3400
3401
NYADMLKRVE PLRNELQKLE DDAKDNQQKA NEVEQMIRDL EASIARYKEE
3450
3451
YAVLISEAQA IKADLAAVEA KVNRSTALLK SLSAERERWE KTSETFKNQM
3500
3501
STIAGDCLLS AAFIAYAGYF DQQMRQNLFT TWSHHLQQAN IQFRTDIART
3550
3551
EYLSNADERL RWQASSLPAD DLCTENAIML KRFNRYPLII DPSGQATEFI
3600
3601
MNEYKDRKIT RTSFLDDAFR KNLESALRFG NPLLVQDVES YDPVLNPVLN
3650
3651
REVRRTGGRV LITLGDQDID LSPSFVIFLS TRDPTVEFPP DLCSRVTFVN
3700
3701
FTVTRSSLQS QCLNEVLKAE RPDVDEKRSD LLKLQGEFQL RLRQLEKSLL
3750
3751
QALNEVKGRI LDDDTIITTL ENLKREAAEV TRKVEETDIV MQEVETVSQQ
3800
3801
YLPLSTACSS IYFTMESLKQ IHFLYQYSLQ FFLDIYHNVL YENPNLKGVT
3850
3851
DHTQRLSIIT KDLFQVAFNR VARGMLHQDH ITFAMLLARI KLKGTVGEPT
3900
3901
YDAEFQHFLR GNEIVLSAGS TPRIQGLTVE QAEAVVRLSC LPAFKDLIAK
3950
3951
VQADEQFGIW LDSSSPEQTV PYLWSEETPA TPIGQAIHRL LLIQAFRPDR
4000
4001
LLAMAHMFVS TNLGESFMSI MEQPLDLTHI VGTEVKPNTP VLMCSVPGYD
4050
4051
ASGHVEDLAA EQNTQITSIA IGSAEGFNQA DKAINTAVKS GRWVMLKNVH
4100
4101
LAPGWLMQLE KKLHSLQPHA CFRLFLTMEI NPKVPVNLLR AGRIFVFEPP
4150
4151
PGVKANMLRT FSSIPVSRIC KSPNERARLY FLLAWFHAII QERLRYAPLG
4200
4201
WSKKYEFGES DLRSACDTVD TWLDDTAKGR QNISPDKIPW SALKTLMAQS
4250
4251
IYGGRVDNEF DQRLLNTFLE RLFTTRSFDS EFKLACKVDG HKDIQMPDGI
4300
4301
RREEFVQWVE LLPDTQTPSW LGLPNNAERV LLTTQGVDMI SKMLKMQMLE
4350
4351
DEDDLAYAET EKKTRTDSTS DGRPAWMRTL HTTASNWLHL IPQTLSHLKR
4400
4401
TVENIKDPLF RFFEREVKMG AKLLQDVRQD LADVVQVCEG KKKQTNYLRT
4450
4451
LINELVKGIL PRSWSHYTVP AGMTVIQWVS DFSERIKQLQ NISLAAASGG
4500
4501
AKELKNIHVC LGGLFVPEAY ITATRQYVAQ ANSWSLEELC LEVNVTTSQG
4550
4551
ATLDACSFGV TGLKLQGATC NNNKLSLSNA ISTALPLTQL RWVKQTNTEK
4600
4601
KASVVTLPVY LNFTRADLIF TVDFEIATKE DPRSFYERGV AVLCTE    
4646
 

Show the unformatted sequence.

Checksums:
CRC64:D4D4E15DFBDE4797
MD5:53e232bb3c645b042ba45225caa50eee

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AAA_6 1868 - 2231 5NUG A 1868 - 2231 Jmol OpenAstexViewer
B 1868 - 2231 Jmol OpenAstexViewer
AAA_7 2557 - 2739 5NUG A 2557 - 2739 Jmol OpenAstexViewer
B 2557 - 2739 Jmol OpenAstexViewer
AAA_8 2907 - 3186 5NUG A 2907 - 3186 Jmol OpenAstexViewer
B 2907 - 3186 Jmol OpenAstexViewer
AAA_9 3560 - 3780 5NUG A 3560 - 3780 Jmol OpenAstexViewer
B 3560 - 3780 Jmol OpenAstexViewer
AAA_lid_11 4154 - 4327 5NUG A 4154 - 4327 Jmol OpenAstexViewer
B 4154 - 4327 Jmol OpenAstexViewer
DHC_N1 242 - 575 6F1U n 242 - 575 Jmol OpenAstexViewer
242 - 629 6F1U m 242 - 629 Jmol OpenAstexViewer
242 - 829 6F1U f 242 - 829 Jmol OpenAstexViewer
242 - 832 6F1T e 242 - 832 Jmol OpenAstexViewer
f 242 - 832 Jmol OpenAstexViewer
m 242 - 832 Jmol OpenAstexViewer
n 242 - 832 Jmol OpenAstexViewer
6F38 e 242 - 832 Jmol OpenAstexViewer
f 242 - 832 Jmol OpenAstexViewer
m 242 - 832 Jmol OpenAstexViewer
n 242 - 832 Jmol OpenAstexViewer
6F3A e 242 - 832 Jmol OpenAstexViewer
f 242 - 832 Jmol OpenAstexViewer
453 - 702 6F1V m 453 - 702 Jmol OpenAstexViewer
517 - 832 6F1V f 517 - 832 Jmol OpenAstexViewer
780 - 832 6F1Y f 780 - 832 Jmol OpenAstexViewer
DHC_N2 1444 - 1720 5NUG A 1444 - 1720 Jmol OpenAstexViewer
B 1444 - 1720 Jmol OpenAstexViewer
Dynein_AAA_lid 2423 - 2550 5NUG A 2423 - 2550 Jmol OpenAstexViewer
B 2423 - 2550 Jmol OpenAstexViewer
Dynein_C 4333 - 4644 5NUG A 4333 - 4644 Jmol OpenAstexViewer
B 4333 - 4644 Jmol OpenAstexViewer
Dynein_heavy 4036 - 4153 5NUG A 4036 - 4153 Jmol OpenAstexViewer
B 4036 - 4153 Jmol OpenAstexViewer
MT 3199 - 3536 5NUG A 3199 - 3536 Jmol OpenAstexViewer
B 3199 - 3536 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.