Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FKBP8_HUMAN (Q14318)

Summary

This is the summary of UniProt entry FKBP8_HUMAN (Q14318).

Description: Peptidyl-prolyl cis-trans isomerase FKBP8 EC=5.2.1.8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 412 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 96
low_complexity n/a 1 15
low_complexity n/a 24 56
coiled_coil n/a 27 47
low_complexity n/a 77 91
disorder n/a 104 140
Pfam FKBP_C 113 201
transmembrane n/a 388 410
low_complexity n/a 390 409

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14318. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS
50
51
ELPPLEDMGQ PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG
100
101
LLRKKTLVPG PPGSSRPVKG QVVTVHLQTS LENGTRVQEE PELVFTLGDC
150
151
DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGRSPYIPP HAALCLEVTL
200
201
KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA ANSYDLAIKA
250
251
ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE
300
301
HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV
350
351
KKHAAQRSTE TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG
400
401
GVALSVVIAA RN                                         
412
 

Show the unformatted sequence.

Checksums:
CRC64:887C25ADE71EBA8D
MD5:98aed2aada093d893e5f656d2f9f6be3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FKBP_C 113 - 201 2AWG A 113 - 201 Jmol OpenAstexViewer
2D9F A 30 - 119 Jmol OpenAstexViewer
2F2D A 56 - 144 Jmol OpenAstexViewer
2MF9 A 56 - 145 Jmol OpenAstexViewer
3EY6 A 56 - 144 Jmol OpenAstexViewer
5MGX E 113 - 201 Jmol OpenAstexViewer
F 113 - 201 Jmol OpenAstexViewer
G 113 - 201 Jmol OpenAstexViewer
H 113 - 201 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.