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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NBR1_HUMAN (Q14596)

Summary

This is the summary of UniProt entry NBR1_HUMAN (Q14596).

Description: Next to BRCA1 gene 1 protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 966 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam PB1 4 85
disorder n/a 55 62
disorder n/a 69 70
disorder n/a 75 76
disorder n/a 79 97
low_complexity n/a 97 111
disorder n/a 99 102
disorder n/a 132 142
disorder n/a 152 153
disorder n/a 192 193
Pfam ZZ 212 253
coiled_coil n/a 295 329
disorder n/a 300 304
disorder n/a 308 313
disorder n/a 316 317
disorder n/a 343 347
Pfam N_BRCA1_IG 379 478
disorder n/a 391 392
disorder n/a 487 499
disorder n/a 516 519
disorder n/a 524 529
disorder n/a 531 536
disorder n/a 579 607
disorder n/a 609 621
disorder n/a 627 638
disorder n/a 640 641
disorder n/a 660 728
low_complexity n/a 687 719
coiled_coil n/a 693 720
disorder n/a 745 803
low_complexity n/a 804 821
disorder n/a 807 817
disorder n/a 819 836
disorder n/a 838 878

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14596. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD
50
51
EENEEVSINS QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK
100
101
RLAARAGKKP LAHYSSLVRV LGSDMKTPED PAVQSFPLVP CDTDQPQDKP
150
151
PDWFTSYLET FREQVVNETV EKLEQKLHEK LVLQNPSLGS CPSEVSMPTS
200
201
EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC EDCEAGPYGH
250
251
DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA
300
301
EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES
350
351
LLQSNTLMLP LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN
400
401
TGNVKWSADT KLKFMWGNLT LASTEKKDVL VPCLKAGHVG VVSVEFIAPA
450
451
LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP FPSEESPDNI EKGMISSSKT
500
501
DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN VASERELYIP
550
551
SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE
600
601
KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC
650
651
ETVIRSLTLD AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA
700
701
VMEEEEDEED EEEEDELKDE VQSQSSASSE DYIIILPECF DTSRPLGDSM
750
751
YSSALSQPGL ERGAEGKPGV EAGQEPAEAG ERLPGGENQP QEHSISDILT
800
801
TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV TIPEVSSVPD
850
851
QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL
900
901
FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV
950
951
TELLQLNNND WYSQRY                                     
966
 

Show the unformatted sequence.

Checksums:
CRC64:6A057E67947838EF
MD5:430bf65d81f221be2c85e3ef7721b484

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
N_BRCA1_IG 379 - 478 4OLE A 379 - 478 Jmol OpenAstexViewer
B 379 - 478 Jmol OpenAstexViewer
C 379 - 478 Jmol OpenAstexViewer
D 379 - 478 Jmol OpenAstexViewer
PB1 4 - 85 1WJ6 A 14 - 95 Jmol OpenAstexViewer
2BKF A 4 - 85 Jmol OpenAstexViewer
2G4S A 4 - 85 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.