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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: K0100_HUMAN (Q14667)

Summary

This is the summary of UniProt entry K0100_HUMAN (Q14667).

Description: Protein KIAA0100
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2235 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 29
low_complexity n/a 3 21
Pfam Fmp27 26 477
low_complexity n/a 334 343
Pfam Fmp27 447 674
disorder n/a 708 721
low_complexity n/a 787 798
low_complexity n/a 860 872
disorder n/a 992 993
Pfam Fmp27_GFWDK 1028 1160
low_complexity n/a 1415 1421
disorder n/a 1427 1442
disorder n/a 1490 1524
disorder n/a 1647 1652
disorder n/a 1665 1666
disorder n/a 1668 1669
disorder n/a 1682 1695
low_complexity n/a 1690 1701
Pfam Apt1 1703 2176
disorder n/a 1725 1741
disorder n/a 1794 1802
coiled_coil n/a 1814 1834
low_complexity n/a 1847 1872
coiled_coil n/a 1848 1879
low_complexity n/a 2035 2045
disorder n/a 2040 2044
disorder n/a 2074 2075
disorder n/a 2087 2090
disorder n/a 2092 2104
disorder n/a 2194 2203
disorder n/a 2229 2234

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14667. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLFFSALLV LLLVALSALF LGRWLVVRLA TKWCQRKLQA ELKIGSFRFF
50
51
WIQNVSLKFQ QHQQTVEIDN LWISSKLLSH DLPHYVALCF GEVRIRTDLQ
100
101
KVSDLSAPFS QSAGVDQKEL SFSPSLLKIF CQLFSIHVDA INIMVLKVDT
150
151
SESLWHIQIS RSRFLLDSDG KRLICEVSLC KINSKVLKSG QLEDTCLVEL
200
201
SLALDLCLKV GISSRHLTAI TVDVWTLHAE LHEGLFQSQL LCQGPSLASK
250
251
PVPCSEVTEN LVEPTLPGLF LLQQLPDQVK VKMENTSVVL SMNSQKRHLT
300
301
WTLKLLQFLY HRDEDQLPLR SFTANSDMAQ MSTELLLEDG LLLSQSRQRI
350
351
VCLNSLKASV QVTTIDLSAS LVLNTCIIHY RHQEFSHWLH LLALETQGSS
400
401
SPVLKQRKKR TFPQILAPII FSTSISNVNI SIQLGDTPPF ALGFNSISLD
450
451
YQHLRPQSIH QRGVLTVDHL CWRVGSDSHI QRAPHPPNMH VWGEALVLDS
500
501
FTLQGSYNQP LGLSSTQSDT LFLDCTIRGL QVEASDTCAQ CLSRILSLMG
550
551
PQSGKSAVSR HSSFGESVSL LWKVDLKVED MNLFTLSALV GASEVRLDTL
600
601
TILGSAETST VGIQGLVLAL VKSVTEKMQP CCKAPDIPTP VLSLSMLSIT
650
651
YHSSIRSLEV QCGAGLTLLW SPPDHMYLYQ HVLATLQCRD LLRATVFPET
700
701
VPSLALETSG TTSELEGRAP EPLPPKRLLN LTLEVSTAKL TAFVAEDKFI
750
751
TLAAESVSLS RHGGSLQAYC PELAAGFDGN SIFNFKEVEV QLLPELEEMI
800
801
LHRNPFPALQ TLRNRVWLLS FGSVSVEFPY QYDFSRTLDE AVGVQKWLKG
850
851
LHQGTRAWAS PSPVPLPPDL LLKVEHFSWV FLDDVFEVKL HDNYELMKDE
900
901
SKESAKRLQL LDAKVAALRK QHGELLPARK IEELYASLER KNIEIYIQRS
950
951
RRLYGNTPMR RALLTWSLAG LELVALADAS FHGPEHVVEQ VQELDPGSPF
1000
1001
PPEGLDLVIQ WCRMLKCNVK SFLVRIRDYP RYLFEIRDWR LMGRLVGTEQ
1050
1051
SGQPCSRRRQ ILHLGLPWGN VAVERNMPPL KFYHDFHSEI FQYTVVWGPC
1100
1101
WDPAWTLIGQ CVDLLTKPSA DPSPPLPWWD KSRLLFHGDW HMDIEQANLH
1150
1151
QLATEDPYNT TENMHWEWSH LSFHWKPGQF VFKGDLDINV RTASKYDDCC
1200
1201
FLHLPDLCMT LDLQWLCHGN PHDHHSVTLR APEFLPEVPL GQLHDSYRAF
1250
1251
RSENLNLSIK MDLTRHSGTI SQPRILLYSS TLRWMQNFWA TWTSVTRPIC
1300
1301
RGKLFNNLKP SKKKLGQHYK QLSYTALFPQ LQVHYWASFA QQRGIQIECS
1350
1351
QGHVFTRGTQ RLIPQAGTVM RRLISDWSVT QMVSDLSQVT VHLMASPTEE
1400
1401
NADHCLDPLV TKTHLLSLSS LTYQRHSNRT AEEELSARDG DPTFHTHQLH
1450
1451
LVDLRISWTT TNRDIAFGLY DGYKKAAVLK RNLSTEALKG LKIDPQMPAK
1500
1501
KPKRGVPTSA SAPPRVNTPS FSGQPDKGSS GGAYMLQKLI EETDRFVVFT
1550
1551
EEESGMSDQL CGIAACQTDD IYNRNCLIEL VNCQMVLRGA ETEGCVIVSA
1600
1601
AKAQLLQCQH HPAWYGDTLK QKTSWTCLLD GMQYFATTES SPTEQDGRQL
1650
1651
WLEVKNIEEH RQRSLDSVQE LMESGQAVGG MVTTTTDWNQ PAEAQQAQQV
1700
1701
QRIISRCNCR MYYISYSHDI DPELATQIKP PEVLENQEKE DLLKKQEGAV
1750
1751
DTFTLIHHEL EISTNPAQYA MILDIVNNLL LHVEPKRKEH SEKKQRVRFQ
1800
1801
LEISSNPEEQ RSSILHLQEA VRQHVAQIRQ LEKQMYSIMK SLQDDSKNEN
1850
1851
LLDLNQKLQL QLNQEKANLQ LESEELNILI RCFKDFQLQR ANKMELRKQQ
1900
1901
EDVSVVRRTE FYFAQARWRL TEEDGQLGIA ELELQRFLYS KVNKSDDTAE
1950
1951
HLLELGWFTM NNLLPNAVYK VVLRPQSSCQ SGRQLALRLF SKVRPPVGGI
2000
2001
SVKEHFEVNV VPLTIQLTHQ FFHRMMGFFF PGRSVEDDEV GDEEDKSKLV
2050
2051
TTGIPVVKPR QLIATDDAVP LGPGKGVAQG LTRSSGVRRS FRKSPEHPVD
2100
2101
DIDKMKERAA MNNSFIYIKI PQVPLCVSYK GEKNSVDWGD LNLVLPCLEY
2150
2151
HNNTWTWLDF AMAVKRDSRK ALVAQVIKEK LRLKSATGSE VRGKLETKSD
2200
2201
LNMQQQEEEE KARLLIGLSV GDKNPGKKSI FGRRK                
2235
 

Show the unformatted sequence.

Checksums:
CRC64:15BCEB09FAEFD7E3
MD5:1c3732020b3d46d879d6bd926288c336

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;