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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KANK1_HUMAN (Q14678)

Summary

This is the summary of UniProt entry KANK1_HUMAN (Q14678).

Description: KN motif and ankyrin repeat domain-containing protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1352 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 27
disorder n/a 29 33
Pfam KN_motif 30 68
disorder n/a 57 188
low_complexity n/a 86 99
disorder n/a 190 259
coiled_coil n/a 260 280
coiled_coil n/a 291 311
disorder n/a 304 305
disorder n/a 330 333
disorder n/a 349 352
low_complexity n/a 349 357
disorder n/a 360 362
coiled_coil n/a 367 394
disorder n/a 385 386
disorder n/a 388 389
disorder n/a 397 400
coiled_coil n/a 448 482
disorder n/a 481 494
disorder n/a 498 499
low_complexity n/a 612 622
disorder n/a 656 680
disorder n/a 682 683
disorder n/a 710 726
disorder n/a 728 730
disorder n/a 735 736
disorder n/a 740 742
disorder n/a 747 759
disorder n/a 791 821
coiled_coil n/a 823 843
disorder n/a 845 848
disorder n/a 852 854
disorder n/a 863 864
disorder n/a 877 893
low_complexity n/a 909 924
disorder n/a 914 955
disorder n/a 961 962
disorder n/a 975 1060
low_complexity n/a 1006 1023
low_complexity n/a 1032 1041
disorder n/a 1063 1078
Pfam Ank 1161 1194
Pfam Ank 1233 1265
Pfam Ank 1266 1299
disorder n/a 1332 1352

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14678. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAHTTKVNGS ASGKAGDILS GDQDKEQKDP YFVETPYGYQ LDLDFLKYVD
50
51
DIQKGNTIKR LNIQKRRKPS VPCPEPRTTS GQQGIWTSTE SLSSSNSDDN
100
101
KQCPNFLIAR SQVTSTPISK PPPPLETSLP FLTIPENRQL PPPSPQLPKH
150
151
NLHVTKTLME TRRRLEQERA TMQMTPGEFR RPRLASFGGM GTTSSLPSFV
200
201
GSGNHNPAKH QLQNGYQGNG DYGSYAPAAP TTSSMGSSIR HSPLSSGIST
250
251
PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ
300
301
LVSQLKNQRA ASQINVCGVR KRSYSAGNAS QLEQLSRARR SGGELYIDYE
350
351
EEEMETVEQS TQRIKEFRQL TADMQALEQK IQDSSCEASS ELRENGECRS
400
401
VAVGAEENMN DIVVYHRGSR SCKDAAVGTL VEMRNCGVSV TEAMLGVMTE
450
451
ADKEIELQQQ TIESLKEKIY RLEVQLRETT HDREMTKLKQ ELQAAGSRKK
500
501
VDKATMAQPL VFSKVVEAVV QTRDQMVGSH MDLVDTCVGT SVETNSVGIS
550
551
CQPECKNKVV GPELPMNWWI VKERVEMHDR CAGRSVEMCD KSVSVEVSVC
600
601
ETGSNTEESV NDLTLLKTNL NLKEVRSIGC GDCSVDVTVC SPKECASRGV
650
651
NTEAVSQVEA AVMAVPRTAD QDTSTDLEQV HQFTNTETAT LIESCTNTCL
700
701
STLDKQTSTQ TVETRTVAVG EGRVKDINSS TKTRSIGVGT LLSGHSGFDR
750
751
PSAVKTKESG VGQININDNY LVGLKMRTIA CGPPQLTVGL TASRRSVGVG
800
801
DDPVGESLEN PQPQAPLGMM TGLDHYIERI QKLLAEQQTL LAENYSELAE
850
851
AFGEPHSQMG SLNSQLISTL SSINSVMKSA STEELRNPDF QKTSLGKITG
900
901
NYLGYTCKCG GLQSGSPLSS QTSQPEQEVG TSEGKPISSL DAFPTQEGTL
950
951
SPVNLTDDQI AAGLYACTNN ESTLKSIMKK KDGNKDSNGA KKNLQFVGIN
1000
1001
GGYETTSSDD SSSDESSSSE SDDECDVIEY PLEEEEEEED EDTRGMAEGH
1050
1051
HAVNIEGLKS ARVEDEMQVQ ECEPEKVEIR ERYELSEKML SACNLLKNTI
1100
1101
NDPKALTSKD MRFCLNTLQH EWFRVSSQKS AIPAMVGDYI AAFEAISPDV
1150
1151
LRYVINLADG NGNTALHYSV SHSNFEIVKL LLDADVCNVD HQNKAGYTPI
1200
1201
MLAALAAVEA EKDMRIVEEL FGCGDVNAKA SQAGQTALML AVSHGRIDMV
1250
1251
KGLLACGADV NIQDDEGSTA LMCASEHGHV EIVKLLLAQP GCNGHLEDND
1300
1301
GSTALSIALE AGHKDIAVLL YAHVNFAKAQ SPGTPRLGRK TSPGPTHRGS
1350
1351
FD                                                    
1352
 

Show the unformatted sequence.

Checksums:
CRC64:0C3993143391363B
MD5:ac88aab701f3b6a930d2f2d00e082287

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ank 1161 - 1194 5YBJ A 1161 - 1194 Jmol OpenAstexViewer
5YBU A 1161 - 1194 Jmol OpenAstexViewer
1233 - 1265 5YBJ A 1233 - 1265 Jmol OpenAstexViewer
5YBU A 1233 - 1265 Jmol OpenAstexViewer
1266 - 1299 5YBJ A 1266 - 1299 Jmol OpenAstexViewer
5YBU A 1266 - 1299 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.