Summary
This is the summary of UniProt entry KANK1_HUMAN (Q14678).
| Description: | KN motif and ankyrin repeat domain-containing protein 1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 1352 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 27 |
| disorder | n/a | 29 | 33 |
| Pfam | KN_motif | 30 | 68 |
| disorder | n/a | 57 | 188 |
| low_complexity | n/a | 86 | 99 |
| disorder | n/a | 190 | 259 |
| coiled_coil | n/a | 260 | 280 |
| coiled_coil | n/a | 291 | 311 |
| disorder | n/a | 304 | 305 |
| disorder | n/a | 330 | 333 |
| disorder | n/a | 349 | 352 |
| low_complexity | n/a | 349 | 357 |
| disorder | n/a | 360 | 362 |
| coiled_coil | n/a | 367 | 394 |
| disorder | n/a | 385 | 386 |
| disorder | n/a | 388 | 389 |
| disorder | n/a | 397 | 400 |
| coiled_coil | n/a | 448 | 482 |
| disorder | n/a | 481 | 494 |
| disorder | n/a | 498 | 499 |
| low_complexity | n/a | 612 | 622 |
| disorder | n/a | 656 | 680 |
| disorder | n/a | 682 | 683 |
| disorder | n/a | 710 | 726 |
| disorder | n/a | 728 | 730 |
| disorder | n/a | 735 | 736 |
| disorder | n/a | 740 | 742 |
| disorder | n/a | 747 | 759 |
| disorder | n/a | 791 | 821 |
| coiled_coil | n/a | 823 | 843 |
| disorder | n/a | 845 | 848 |
| disorder | n/a | 852 | 854 |
| disorder | n/a | 863 | 864 |
| disorder | n/a | 877 | 893 |
| low_complexity | n/a | 909 | 924 |
| disorder | n/a | 914 | 955 |
| disorder | n/a | 961 | 962 |
| disorder | n/a | 975 | 1060 |
| low_complexity | n/a | 1006 | 1023 |
| low_complexity | n/a | 1032 | 1041 |
| disorder | n/a | 1063 | 1078 |
| Pfam | Ank | 1161 | 1194 |
| Pfam | Ank | 1233 | 1265 |
| Pfam | Ank | 1266 | 1299 |
| disorder | n/a | 1332 | 1352 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q14678. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAHTTKVNGS ASGKAGDILS GDQDKEQKDP YFVETPYGYQ LDLDFLKYVD
50 51
DIQKGNTIKR LNIQKRRKPS VPCPEPRTTS GQQGIWTSTE SLSSSNSDDN
100 101
KQCPNFLIAR SQVTSTPISK PPPPLETSLP FLTIPENRQL PPPSPQLPKH
150 151
NLHVTKTLME TRRRLEQERA TMQMTPGEFR RPRLASFGGM GTTSSLPSFV
200 201
GSGNHNPAKH QLQNGYQGNG DYGSYAPAAP TTSSMGSSIR HSPLSSGIST
250 251
PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ
300 301
LVSQLKNQRA ASQINVCGVR KRSYSAGNAS QLEQLSRARR SGGELYIDYE
350 351
EEEMETVEQS TQRIKEFRQL TADMQALEQK IQDSSCEASS ELRENGECRS
400 401
VAVGAEENMN DIVVYHRGSR SCKDAAVGTL VEMRNCGVSV TEAMLGVMTE
450 451
ADKEIELQQQ TIESLKEKIY RLEVQLRETT HDREMTKLKQ ELQAAGSRKK
500 501
VDKATMAQPL VFSKVVEAVV QTRDQMVGSH MDLVDTCVGT SVETNSVGIS
550 551
CQPECKNKVV GPELPMNWWI VKERVEMHDR CAGRSVEMCD KSVSVEVSVC
600 601
ETGSNTEESV NDLTLLKTNL NLKEVRSIGC GDCSVDVTVC SPKECASRGV
650 651
NTEAVSQVEA AVMAVPRTAD QDTSTDLEQV HQFTNTETAT LIESCTNTCL
700 701
STLDKQTSTQ TVETRTVAVG EGRVKDINSS TKTRSIGVGT LLSGHSGFDR
750 751
PSAVKTKESG VGQININDNY LVGLKMRTIA CGPPQLTVGL TASRRSVGVG
800 801
DDPVGESLEN PQPQAPLGMM TGLDHYIERI QKLLAEQQTL LAENYSELAE
850 851
AFGEPHSQMG SLNSQLISTL SSINSVMKSA STEELRNPDF QKTSLGKITG
900 901
NYLGYTCKCG GLQSGSPLSS QTSQPEQEVG TSEGKPISSL DAFPTQEGTL
950 951
SPVNLTDDQI AAGLYACTNN ESTLKSIMKK KDGNKDSNGA KKNLQFVGIN
1000 1001
GGYETTSSDD SSSDESSSSE SDDECDVIEY PLEEEEEEED EDTRGMAEGH
1050 1051
HAVNIEGLKS ARVEDEMQVQ ECEPEKVEIR ERYELSEKML SACNLLKNTI
1100 1101
NDPKALTSKD MRFCLNTLQH EWFRVSSQKS AIPAMVGDYI AAFEAISPDV
1150 1151
LRYVINLADG NGNTALHYSV SHSNFEIVKL LLDADVCNVD HQNKAGYTPI
1200 1201
MLAALAAVEA EKDMRIVEEL FGCGDVNAKA SQAGQTALML AVSHGRIDMV
1250 1251
KGLLACGADV NIQDDEGSTA LMCASEHGHV EIVKLLLAQP GCNGHLEDND
1300 1301
GSTALSIALE AGHKDIAVLL YAHVNFAKAQ SPGTPRLGRK TSPGPTHRGS
1350 1351
FD
1352
Show the unformatted sequence. |
| Checksums: |
CRC64:0C3993143391363B
MD5:ac88aab701f3b6a930d2f2d00e082287
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Ank | 1161 - 1194 | 5YBJ | A | 1161 - 1194 | Jmol OpenAstexViewer |
| 5YBU | A | 1161 - 1194 | Jmol OpenAstexViewer | ||
| 1233 - 1265 | 5YBJ | A | 1233 - 1265 | Jmol OpenAstexViewer | |
| 5YBU | A | 1233 - 1265 | Jmol OpenAstexViewer | ||
| 1266 - 1299 | 5YBJ | A | 1266 - 1299 | Jmol OpenAstexViewer | |
| 5YBU | A | 1266 - 1299 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
