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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CHD4_HUMAN (Q14839)

Summary

This is the summary of UniProt entry CHD4_HUMAN (Q14839).

Description: Chromodomain-helicase-DNA-binding protein 4 EC=3.6.4.12
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1912 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 160
low_complexity n/a 28 49
low_complexity n/a 49 69
low_complexity n/a 87 99
low_complexity n/a 114 151
Pfam CHDNT 164 217
disorder n/a 212 224
low_complexity n/a 224 247
disorder n/a 239 298
low_complexity n/a 241 256
low_complexity n/a 278 298
disorder n/a 300 361
low_complexity n/a 303 310
low_complexity n/a 303 310
low_complexity n/a 308 325
low_complexity n/a 335 354
Pfam PHD 372 417
disorder n/a 425 440
low_complexity n/a 429 446
Pfam PHD 451 496
disorder n/a 511 538
low_complexity n/a 513 534
disorder n/a 578 603
Pfam Chromo 622 674
low_complexity n/a 682 701
disorder n/a 683 685
disorder n/a 689 698
disorder n/a 703 714
Pfam SNF2-rel_dom 728 1025
low_complexity n/a 905 919
Pfam Helicase_C 1050 1164
low_complexity n/a 1051 1063
disorder n/a 1229 1246
disorder n/a 1257 1274
disorder n/a 1288 1306
coiled_coil n/a 1288 1308
low_complexity n/a 1289 1307
Pfam DUF1087 1292 1352
disorder n/a 1313 1321
disorder n/a 1325 1401
low_complexity n/a 1349 1367
Pfam CHDII_SANT-like 1380 1521
disorder n/a 1442 1444
disorder n/a 1473 1486
disorder n/a 1512 1688
low_complexity n/a 1533 1547
low_complexity n/a 1564 1585
low_complexity n/a 1603 1630
coiled_coil n/a 1656 1677
low_complexity n/a 1660 1671
Pfam CHDCT2 1725 1871
disorder n/a 1833 1842
coiled_coil n/a 1847 1867
disorder n/a 1892 1912

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14839. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK
50
51
LKKKKKPKKP RDPKIPKSKR QKKERMLLCR QLGDSSGEGP EFVEEEEEVA
100
101
LRSDSEGSDY TPGKKKKKKL GPKKEKKSKS KRKEEEEEED DDDDSKEPKS
150
151
SAQLLEDWGM EDIDHVFSEE DYRTLTNYKA FSQFVRPLIA AKNPKIAVSK
200
201
MMMVLGAKWR EFSTNNPFKG SSGASVAAAA AAAVAVVESM VTATEVAPPP
250
251
PPVEVPIRKA KTKEGKGPNA RRKPKGSPRV PDAKKPKPKK VAPLKIKLGG
300
301
FGSKRKRSSS EDDDLDVESD FDDASINSYS VSDGSTSRSS RSRKKLRTTK
350
351
KKKKGEEEVT AVDGYETDHQ DYCEVCQQGG EIILCDTCPR AYHMVCLDPD
400
401
MEKAPEGKWS CPHCEKEGIQ WEAKEDNSEG EEILEEVGGD LEEEDDHHME
450
451
FCRVCKDGGE LLCCDTCPSS YHIHCLNPPL PEIPNGEWLC PRCTCPALKG
500
501
KVQKILIWKW GQPPSPTPVP RPPDADPNTP SPKPLEGRPE RQFFVKWQGM
550
551
SYWHCSWVSE LQLELHCQVM FRNYQRKNDM DEPPSGDFGG DEEKSRKRKN
600
601
KDPKFAEMEE RFYRYGIKPE WMMIHRILNH SVDKKGHVHY LIKWRDLPYD
650
651
QASWESEDVE IQDYDLFKQS YWNHRELMRG EEGRPGKKLK KVKLRKLERP
700
701
PETPTVDPTV KYERQPEYLD ATGGTLHPYQ MEGLNWLRFS WAQGTDTILA
750
751
DEMGLGKTVQ TAVFLYSLYK EGHSKGPFLV SAPLSTIINW EREFEMWAPD
800
801
MYVVTYVGDK DSRAIIRENE FSFEDNAIRG GKKASRMKKE ASVKFHVLLT
850
851
SYELITIDMA ILGSIDWACL IVDEAHRLKN NQSKFFRVLN GYSLQHKLLL
900
901
TGTPLQNNLE ELFHLLNFLT PERFHNLEGF LEEFADIAKE DQIKKLHDML
950
951
GPHMLRRLKA DVFKNMPSKT ELIVRVELSP MQKKYYKYIL TRNFEALNAR
1000
1001
GGGNQVSLLN VVMDLKKCCN HPYLFPVAAM EAPKMPNGMY DGSALIRASG
1050
1051
KLLLLQKMLK NLKEGGHRVL IFSQMTKMLD LLEDFLEHEG YKYERIDGGI
1100
1101
TGNMRQEAID RFNAPGAQQF CFLLSTRAGG LGINLATADT VIIYDSDWNP
1150
1151
HNDIQAFSRA HRIGQNKKVM IYRFVTRASV EERITQVAKK KMMLTHLVVR
1200
1201
PGLGSKTGSM SKQELDDILK FGTEELFKDE ATDGGGDNKE GEDSSVIHYD
1250
1251
DKAIERLLDR NQDETEDTEL QGMNEYLSSF KVAQYVVREE EMGEEEEVER
1300
1301
EIIKQEESVD PDYWEKLLRH HYEQQQEDLA RNLGKGKRIR KQVNYNDGSQ
1350
1351
EDRDWQDDQS DNQSDYSVAS EEGDEDFDER SEAPRRPSRK GLRNDKDKPL
1400
1401
PPLLARVGGN IEVLGFNARQ RKAFLNAIMR YGMPPQDAFT TQWLVRDLRG
1450
1451
KSEKEFKAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ HVLTRIGVMS
1500
1501
LIRKKVQEFE HVNGRWSMPE LAEVEENKKM SQPGSPSPKT PTPSTPGDTQ
1550
1551
PNTPAPVPPA EDGIKIEENS LKEEESIEGE KEVKSTAPET AIECTQAPAP
1600
1601
ASEDEKVVVE PPEGEEKVEK AEVKERTEEP METEPKGAAD VEKVEEKSAI
1650
1651
DLTPIVVEDK EEKKEEEEKK EVMLQNGETP KDLNDEKQKK NIKQRFMFNI
1700
1701
ADGGFTELHS LWQNEERAAT VTKKTYEIWH RRHDYWLLAG IINHGYARWQ
1750
1751
DIQNDPRYAI LNEPFKGEMN RGNFLEIKNK FLARRFKLLE QALVIEEQLR
1800
1801
RAAYLNMSED PSHPSMALNT RFAEVECLAE SHQHLSKESM AGNKPANAVL
1850
1851
HKVLKQLEEL LSDMKADVTR LPATIARIPP VAVRLQMSER NILSRLANRA
1900
1901
PEPTPQQVAQ QQ                                         
1912
 

Show the unformatted sequence.

Checksums:
CRC64:765ED8485B7BBB85
MD5:71aa4147bcf92897d0d7c1af7c48033a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CHDNT 164 - 217 2N5N A 164 - 217 Show 3D Structure View in InterPro
Chromo 622 - 674 2EE1 A 12 - 64 Show 3D Structure View in InterPro
4O9I X 145 - 197 Show 3D Structure View in InterPro
6Q3M A 622 - 674 Show 3D Structure View in InterPro
B 622 - 674 Show 3D Structure View in InterPro
C 622 - 674 Show 3D Structure View in InterPro
D 622 - 674 Show 3D Structure View in InterPro
6RYR W 622 - 674 Show 3D Structure View in InterPro
6RYU V 622 - 674 Show 3D Structure View in InterPro
W 622 - 674 Show 3D Structure View in InterPro
Helicase_C 1050 - 1164 6RYR W 1050 - 1164 Show 3D Structure View in InterPro
6RYU V 1050 - 1164 Show 3D Structure View in InterPro
W 1050 - 1164 Show 3D Structure View in InterPro
PHD 372 - 417 2L5U A 13 - 58 Show 3D Structure View in InterPro
451 - 496 1MM2 A 11 - 56 Show 3D Structure View in InterPro
1MM3 A 11 - 56 Show 3D Structure View in InterPro
2L75 A 92 - 137 Show 3D Structure View in InterPro
6Q3M A 451 - 496 Show 3D Structure View in InterPro
B 451 - 496 Show 3D Structure View in InterPro
C 451 - 496 Show 3D Structure View in InterPro
D 451 - 496 Show 3D Structure View in InterPro
6RYR W 451 - 496 Show 3D Structure View in InterPro
6RYU V 451 - 496 Show 3D Structure View in InterPro
W 451 - 496 Show 3D Structure View in InterPro
SNF2-rel_dom 728 - 1025 6RYR W 728 - 1025 Show 3D Structure View in InterPro
6RYU V 728 - 1025 Show 3D Structure View in InterPro
W 728 - 1025 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;