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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PDIA6_HUMAN (Q15084)

Summary

This is the summary of UniProt entry PDIA6_HUMAN (Q15084).

Description: Protein disulfide-isomerase A6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 440 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 22
Pfam Thioredoxin 26 129
low_complexity n/a 71 85
disorder n/a 114 117
low_complexity n/a 138 154
disorder n/a 145 153
low_complexity n/a 147 161
disorder n/a 156 162
Pfam Thioredoxin 161 267
disorder n/a 413 415
disorder n/a 417 418
low_complexity n/a 421 435

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15084. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALLVLGLVS CTFFLAVNGL YSSSDDVIEL TPSNFNREVI QSDSLWLVEF
50
51
YAPWCGHCQR LTPEWKKAAT ALKDVVKVGA VDADKHHSLG GQYGVQGFPT
100
101
IKIFGSNKNR PEDYQGGRTG EAIVDAALSA LRQLVKDRLG GRSGGYSSGK
150
151
QGRSDSSSKK DVIELTDDSF DKNVLDSEDV WMVEFYAPWC GHCKNLEPEW
200
201
AAAASEVKEQ TKGKVKLAAV DATVNQVLAS RYGIRGFPTI KIFQKGESPV
250
251
DYDGGRTRSD IVSRALDLFS DNAPPPELLE IINEDIAKRT CEEHQLCVVA
300
301
VLPHILDTGA AGRNSYLEVL LKLADKYKKK MWGWLWTEAG AQSELETALG
350
351
IGGFGYPAMA AINARKMKFA LLKGSFSEQG INEFLRELSF GRGSTAPVGG
400
401
GAFPTIVERE PWDGRDGELP VEDDIDLSDV ELDDLGKDEL           
440
 

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Checksums:
CRC64:06895409F0265D7C
MD5:ea2779d58d79db2f81f12962d8741fc2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Thioredoxin 161 - 267 1X5D A 8 - 114 Show 3D Structure View in InterPro
4GWR A 161 - 267 Show 3D Structure View in InterPro
B 161 - 267 Show 3D Structure View in InterPro
26 - 129 3VWW A 28 - 131 Show 3D Structure View in InterPro
B 28 - 131 Show 3D Structure View in InterPro
3W8J A 26 - 129 Show 3D Structure View in InterPro
B 26 - 129 Show 3D Structure View in InterPro
27 - 129 4EF0 A 27 - 129 Show 3D Structure View in InterPro
B 27 - 129 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;