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30  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PDK2_HUMAN (Q15119)

Summary

This is the summary of UniProt entry PDK2_HUMAN (Q15119).

Description: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial EC=2.7.11.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 407 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam BCDHK_Adom3 30 192
disorder n/a 187 189
Pfam HATPase_c 240 364
low_complexity n/a 310 325
disorder n/a 403 407

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15119. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRWVWALLKN ASLAGAPKYI EHFSKFSPSP LSMKQFLDFG SSNACEKTSF
50
51
TFLRQELPVR LANIMKEINL LPDRVLSTPS VQLVQSWYVQ SLLDIMEFLD
100
101
KDPEDHRTLS QFTDALVTIR NRHNDVVPTM AQGVLEYKDT YGDDPVSNQN
150
151
IQYFLDRFYL SRISIRMLIN QHTLIFDGST NPAHPKHIGS IDPNCNVSEV
200
201
VKDAYDMAKL LCDKYYMASP DLEIQEINAA NSKQPIHMVY VPSHLYHMLF
250
251
ELFKNAMRAT VESHESSLIL PPIKVMVALG EEDLSIKMSD RGGGVPLRKI
300
301
ERLFSYMYST APTPQPGTGG TPLAGFGYGL PISRLYAKYF QGDLQLFSME
350
351
GFGTDAVIYL KALSTDSVER LPVYNKSAWR HYQTIQEAGD WCVPSTEPKN
400
401
TSTYRVS                                               
407
 

Show the unformatted sequence.

Checksums:
CRC64:77DBA03EF922EF03
MD5:cbc4b2cb41c828cfed2e5cdc32b2f549

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BCDHK_Adom3 30 - 192 2BTZ A 22 - 184 Show 3D Structure View in InterPro
2BU2 A 22 - 184 Show 3D Structure View in InterPro
2BU5 A 22 - 184 Show 3D Structure View in InterPro
2BU6 A 22 - 184 Show 3D Structure View in InterPro
2BU7 A 22 - 184 Show 3D Structure View in InterPro
2BU8 A 22 - 184 Show 3D Structure View in InterPro
4MP2 A 30 - 192 Show 3D Structure View in InterPro
4MP7 A 30 - 192 Show 3D Structure View in InterPro
4MPC A 30 - 192 Show 3D Structure View in InterPro
4MPE A 30 - 192 Show 3D Structure View in InterPro
4MPN A 30 - 192 Show 3D Structure View in InterPro
4V25 A 22 - 184 Show 3D Structure View in InterPro
4V26 A 22 - 184 Show 3D Structure View in InterPro
5J6A A 30 - 192 Show 3D Structure View in InterPro
5J71 A 30 - 192 Show 3D Structure View in InterPro
5M4K A 22 - 184 Show 3D Structure View in InterPro
5M4M A 22 - 184 Show 3D Structure View in InterPro
5M4N A 22 - 184 Show 3D Structure View in InterPro
5M4P A 22 - 184 Show 3D Structure View in InterPro
6LIL A 30 - 192 Show 3D Structure View in InterPro
B 30 - 192 Show 3D Structure View in InterPro
6LIN A 30 - 192 Show 3D Structure View in InterPro
B 30 - 192 Show 3D Structure View in InterPro
C 30 - 192 Show 3D Structure View in InterPro
D 30 - 192 Show 3D Structure View in InterPro
6LIO A 30 - 192 Show 3D Structure View in InterPro
B 30 - 192 Show 3D Structure View in InterPro
6TMP AAA 22 - 184 Show 3D Structure View in InterPro
6TMQ AAA 22 - 184 Show 3D Structure View in InterPro
6TMZ AAA 22 - 184 Show 3D Structure View in InterPro
6TN0 AAA 22 - 184 Show 3D Structure View in InterPro
6TN2 AAA 22 - 184 Show 3D Structure View in InterPro
7EA0 A 30 - 192 Show 3D Structure View in InterPro
7EAS A 30 - 192 Show 3D Structure View in InterPro
7EBH A 30 - 192 Show 3D Structure View in InterPro
HATPase_c 240 - 364 2BTZ A 232 - 356 Show 3D Structure View in InterPro
2BU2 A 232 - 356 Show 3D Structure View in InterPro
2BU5 A 232 - 356 Show 3D Structure View in InterPro
2BU6 A 232 - 356 Show 3D Structure View in InterPro
2BU7 A 232 - 356 Show 3D Structure View in InterPro
2BU8 A 232 - 356 Show 3D Structure View in InterPro
4MP2 A 240 - 364 Show 3D Structure View in InterPro
4MP7 A 240 - 364 Show 3D Structure View in InterPro
4MPC A 240 - 364 Show 3D Structure View in InterPro
4MPE A 240 - 364 Show 3D Structure View in InterPro
4MPN A 240 - 364 Show 3D Structure View in InterPro
4V25 A 232 - 356 Show 3D Structure View in InterPro
4V26 A 232 - 356 Show 3D Structure View in InterPro
5J6A A 240 - 364 Show 3D Structure View in InterPro
5J71 A 240 - 364 Show 3D Structure View in InterPro
5M4K A 232 - 356 Show 3D Structure View in InterPro
5M4M A 232 - 356 Show 3D Structure View in InterPro
5M4N A 232 - 356 Show 3D Structure View in InterPro
5M4P A 232 - 356 Show 3D Structure View in InterPro
6LIL A 240 - 364 Show 3D Structure View in InterPro
B 240 - 364 Show 3D Structure View in InterPro
6LIN A 240 - 364 Show 3D Structure View in InterPro
B 240 - 364 Show 3D Structure View in InterPro
C 240 - 364 Show 3D Structure View in InterPro
D 240 - 364 Show 3D Structure View in InterPro
6LIO A 240 - 364 Show 3D Structure View in InterPro
B 240 - 364 Show 3D Structure View in InterPro
6TMP AAA 232 - 356 Show 3D Structure View in InterPro
6TMQ AAA 232 - 356 Show 3D Structure View in InterPro
6TMZ AAA 232 - 356 Show 3D Structure View in InterPro
6TN0 AAA 232 - 356 Show 3D Structure View in InterPro
6TN2 AAA 232 - 356 Show 3D Structure View in InterPro
7EA0 A 240 - 364 Show 3D Structure View in InterPro
7EAS A 240 - 364 Show 3D Structure View in InterPro
7EBH A 240 - 364 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;