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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AAAT_HUMAN (Q15758)

Summary

This is the summary of UniProt entry AAAT_HUMAN (Q15758).

Description: Neutral amino acid transporter B(0)
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 541 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 9 11
low_complexity n/a 51 82
transmembrane n/a 53 79
Pfam SDF 54 485
low_complexity n/a 95 107
transmembrane n/a 99 119
low_complexity n/a 122 136
low_complexity n/a 129 145
transmembrane n/a 131 153
low_complexity n/a 140 161
low_complexity n/a 156 172
transmembrane n/a 228 245
transmembrane n/a 266 290
transmembrane n/a 302 328
transmembrane n/a 335 357
low_complexity n/a 345 356
transmembrane n/a 377 402
transmembrane n/a 414 443
disorder n/a 497 498
disorder n/a 516 528
disorder n/a 532 540

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15758. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR
50
51
ANLLVLLTVV AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL
100
101
RMIILPLVVC SLIGGAASLD PGALGRLGAW ALLFFLVTTL LASALGVGLA
150
151
LALQPGAASA AINASVGAAG SAENAPSKEV LDSFLDLARN IFPSNLVSAA
200
201
FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV FGVALRKLGP
250
251
EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA
300
301
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT
350
351
SSSSATLPLM MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF
400
401
IAQLSQQSLD FVKIITILVT ATASSVGAAG IPAGGVLTLA IILEAVNLPV
450
451
DHISLILAVD WLVDRSCTVL NVEGDALGAG LLQNYVDRTE SRSTEPELIQ
500
501
VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV M         
541
 

Show the unformatted sequence.

Checksums:
CRC64:AD61C789CCFFE934
MD5:b6cab29753d5305826944712919730ff

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SDF 54 - 480 5LLM A 50 - 472 Show 3D Structure View in InterPro
5LLU A 50 - 472 Show 3D Structure View in InterPro
5LM4 A 50 - 472 Show 3D Structure View in InterPro
5MJU A 50 - 472 Show 3D Structure View in InterPro
54 - 485 6GCT A 54 - 485 Show 3D Structure View in InterPro
B 54 - 485 Show 3D Structure View in InterPro
C 54 - 485 Show 3D Structure View in InterPro
6MP6 A 54 - 485 Show 3D Structure View in InterPro
B 54 - 485 Show 3D Structure View in InterPro
C 54 - 485 Show 3D Structure View in InterPro
6MPB A 54 - 485 Show 3D Structure View in InterPro
B 54 - 485 Show 3D Structure View in InterPro
C 54 - 485 Show 3D Structure View in InterPro
6RVX A 54 - 485 Show 3D Structure View in InterPro
B 54 - 485 Show 3D Structure View in InterPro
C 54 - 485 Show 3D Structure View in InterPro
6RVY A 54 - 485 Show 3D Structure View in InterPro
B 54 - 485 Show 3D Structure View in InterPro
C 54 - 485 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;