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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ITSN1_HUMAN (Q15811)

Summary

This is the summary of UniProt entry ITSN1_HUMAN (Q15811).

Description: Intersectin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1721 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam EF-hand_4 16 108
disorder n/a 180 194
low_complexity n/a 182 192
disorder n/a 196 197
disorder n/a 199 200
Pfam EF-hand_4 216 312
disorder n/a 234 237
disorder n/a 239 248
low_complexity n/a 294 306
disorder n/a 295 307
low_complexity n/a 307 325
disorder n/a 320 343
disorder n/a 345 351
coiled_coil n/a 355 509
disorder n/a 359 361
disorder n/a 369 371
disorder n/a 380 381
disorder n/a 383 405
low_complexity n/a 384 446
disorder n/a 426 429
disorder n/a 434 435
low_complexity n/a 439 458
low_complexity n/a 450 462
disorder n/a 482 484
disorder n/a 514 515
low_complexity n/a 527 538
disorder n/a 552 553
coiled_coil n/a 565 659
disorder n/a 582 590
disorder n/a 611 732
low_complexity n/a 678 691
low_complexity n/a 685 700
Pfam SH3_9 747 802
disorder n/a 756 757
disorder n/a 759 789
disorder n/a 796 881
Pfam INTAP 803 917
disorder n/a 883 912
disorder n/a 918 920
Pfam SH3_1 919 963
disorder n/a 976 995
Pfam SH3_2 1007 1057
disorder n/a 1060 1063
disorder n/a 1065 1071
Pfam SH3_2 1078 1136
disorder n/a 1113 1115
disorder n/a 1139 1148
Pfam SH3_1 1161 1206
Pfam RhoGEF 1241 1421
disorder n/a 1400 1408
coiled_coil n/a 1410 1430
Pfam PH_13 1440 1593
Pfam C2 1596 1696

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15811. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ
50
51
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP
100
101
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV
150
151
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK
200
201
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM
250
251
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
300
301
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF
350
351
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE
400
401
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE
450
451
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR
500
501
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND
550
551
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI
600
601
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ
650
651
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE
700
701
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP
750
751
FESRSHDEIT IQPGDIVMVK GEWVDESQTG EPGWLGGELK GKTGWFPANY
800
801
AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS SEPSTTPNNW
850
851
ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG
900
901
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW
950
951
FGEVQGQKGW FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP
1000
1001
VVSGEEFIAM YTYESSEQGD LTFQQGDVIL VTKKDGDWWT GTVGDKAGVF
1050
1051
PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ VIASYTATGP EQLTLAPGQL
1100
1101
ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT SKITPTEPPK
1150
1151
STALAAVCQV IGMYDYTAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ
1200
1201
VGLFPSNYVK LTTDMDPSQQ WCSDLHLLDM LTPTERKRQG YIHELIVTEE
1250
1251
NYVNDLQLVT EIFQKPLMES ELLTEKEVAM IFVNWKELIM CNIKLLKALR
1300
1301
VRKKMSGEKM PVKMIGDILS AQLPHMQPYI RFCSRQLNGA ALIQQKTDEA
1350
1351
PDFKEFVKRL AMDPRCKGMP LSSFILKPMQ RVTRYPLIIK NILENTPENH
1400
1401
PDHSHLKHAL EKAEELCSQV NEGVREKENS DRLEWIQAHV QCEGLSEQLV
1450
1451
FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QITKPLGSSG
1500
1501
TDKVFSPKSN LQYKMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT
1550
1551
LRAESINERT AWVQKIKAAS ELYIETEKKK REKAYLVRSQ RATGIGRLMV
1600
1601
NVVEGIELKP CRSHGKSNPY CEVTMGSQCH ITKTIQDTLN PKWNSNCQFF
1650
1651
IRDLEQEVLC ITVFERDQFS PDDFLGRTEI RVADIKKDQG SKGPVTKCLL
1700
1701
LHEVPTGEIV VRLDLQLFDE P                               
1721
 

Show the unformatted sequence.

Checksums:
CRC64:FC4DE644D8BEA2BE
MD5:1a566664fdd7c8ef7fd298cac651326a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EF-hand_4 16 - 103 3FIA A 16 - 103 Show 3D Structure View in InterPro
16 - 108 2KHN A 26 - 118 Show 3D Structure View in InterPro
216 - 312 2KGR A 7 - 103 Show 3D Structure View in InterPro
INTAP 803 - 806 6H5T A 798 - 801 Show 3D Structure View in InterPro
803 - 808 6H5T B 798 - 803 Show 3D Structure View in InterPro
916 - 917 4IIM A 916 - 917 Show 3D Structure View in InterPro
B 916 - 917 Show 3D Structure View in InterPro
PH_13 1440 - 1578 3QBV B 1440 - 1578 Show 3D Structure View in InterPro
1440 - 1579 3QBV D 1440 - 1579 Show 3D Structure View in InterPro
5HZK B 1583 - 1722 Show 3D Structure View in InterPro
1440 - 1580 5HZI A 1583 - 1723 Show 3D Structure View in InterPro
B 1583 - 1723 Show 3D Structure View in InterPro
5HZJ A 1583 - 1723 Show 3D Structure View in InterPro
B 1583 - 1723 Show 3D Structure View in InterPro
5HZK D 1583 - 1723 Show 3D Structure View in InterPro
1440 - 1581 1KI1 B 1440 - 1580 Show 3D Structure View in InterPro
D 1440 - 1580 Show 3D Structure View in InterPro
RhoGEF 1241 - 1421 1KI1 B 1241 - 1421 Show 3D Structure View in InterPro
D 1241 - 1421 Show 3D Structure View in InterPro
3QBV B 1241 - 1421 Show 3D Structure View in InterPro
D 1241 - 1421 Show 3D Structure View in InterPro
5HZI A 1241 - 1564 Show 3D Structure View in InterPro
B 1241 - 1564 Show 3D Structure View in InterPro
5HZJ A 1241 - 1564 Show 3D Structure View in InterPro
B 1241 - 1564 Show 3D Structure View in InterPro
5HZK B 1241 - 1564 Show 3D Structure View in InterPro
D 1241 - 1564 Show 3D Structure View in InterPro
SH3_1 919 - 963 4IIM A 919 - 963 Show 3D Structure View in InterPro
B 919 - 963 Show 3D Structure View in InterPro
SH3_2 1078 - 1136 6GBU B 5 - 63 Show 3D Structure View in InterPro
D 5 - 63 Show 3D Structure View in InterPro
F 5 - 63 Show 3D Structure View in InterPro
H 5 - 63 Show 3D Structure View in InterPro
SH3_9 747 - 802 6H5T A 747 - 797 Show 3D Structure View in InterPro
B 747 - 797 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;