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17  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EZH2_HUMAN (Q15910)

Summary

This is the summary of UniProt entry EZH2_HUMAN (Q15910).

Description: Histone-lysine N-methyltransferase EZH2 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 746 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 7
disorder n/a 9 11
Pfam EZH2_WD-Binding 39 68
Pfam PRC2_HTH_1 158 249
disorder n/a 177 219
low_complexity n/a 182 191
disorder n/a 221 222
low_complexity n/a 237 251
disorder n/a 238 277
disorder n/a 305 313
disorder n/a 315 322
disorder n/a 335 432
low_complexity n/a 348 365
low_complexity n/a 384 408
disorder n/a 478 491
Pfam preSET_CXC 559 590
Pfam SET 623 727

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15910. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL
50
51
ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT
100
101
LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI
150
151
KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPEEREEKQ
200
201
KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ
250
251
QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH
300
301
ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP
350
351
GGRRRGRLPN NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK
400
401
KDETSSSSEA NSRCQTPIKM KPNIEPPENV EWSGAEASMF RVLIGTYYDN
450
451
FCAIARLIGT KTCRQVYEFR VKESSIIAPA PAEDVDTPPR KKKRKHRLWA
500
501
AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ NFCEKFCQCS
550
551
SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS
600
601
CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE
650
651
ADRRGKVYDK YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM
700
701
MVNGDHRIGI FAKRAIQTGE ELFFDYRYSQ ADALKYVGIE REMEIP    
746
 

Show the unformatted sequence.

Checksums:
CRC64:1B5029EB9D509BE5
MD5:6b234210507cf6ae2336d0f32b29e201

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EZH2_WD-Binding 39 - 66 5WG6 C 39 - 66 Jmol OpenAstexViewer
39 - 68 5HYN A 39 - 68 Jmol OpenAstexViewer
F 39 - 68 Jmol OpenAstexViewer
K 39 - 68 Jmol OpenAstexViewer
Q 39 - 68 Jmol OpenAstexViewer
5LS6 A 39 - 68 Jmol OpenAstexViewer
D 39 - 68 Jmol OpenAstexViewer
G 39 - 68 Jmol OpenAstexViewer
J 39 - 68 Jmol OpenAstexViewer
5WG6 A 39 - 68 Jmol OpenAstexViewer
6C23 C 39 - 68 Jmol OpenAstexViewer
6C24 C 39 - 68 Jmol OpenAstexViewer
40 - 66 5H17 B 40 - 66 Jmol OpenAstexViewer
40 - 68 5GSA C 40 - 68 Jmol OpenAstexViewer
D 40 - 68 Jmol OpenAstexViewer
5H14 C 40 - 68 Jmol OpenAstexViewer
D 40 - 68 Jmol OpenAstexViewer
5H15 C 40 - 68 Jmol OpenAstexViewer
D 40 - 68 Jmol OpenAstexViewer
5H19 B 40 - 68 Jmol OpenAstexViewer
5H24 C 40 - 68 Jmol OpenAstexViewer
D 40 - 68 Jmol OpenAstexViewer
5H25 C 40 - 68 Jmol OpenAstexViewer
D 40 - 68 Jmol OpenAstexViewer
41 - 68 5U5T D 41 - 68 Jmol OpenAstexViewer
5U62 D 41 - 68 Jmol OpenAstexViewer
5WUK B 41 - 68 Jmol OpenAstexViewer
43 - 68 5U5T C 43 - 68 Jmol OpenAstexViewer
5U62 C 43 - 68 Jmol OpenAstexViewer
PRC2_HTH_1 158 - 247 5HYN K 158 - 247 Jmol OpenAstexViewer
6C23 C 158 - 247 Jmol OpenAstexViewer
158 - 248 5HYN F 158 - 248 Jmol OpenAstexViewer
Q 158 - 248 Jmol OpenAstexViewer
158 - 249 5HYN A 158 - 249 Jmol OpenAstexViewer
5LS6 A 158 - 249 Jmol OpenAstexViewer
D 158 - 249 Jmol OpenAstexViewer
G 158 - 249 Jmol OpenAstexViewer
J 158 - 249 Jmol OpenAstexViewer
164 - 247 6C24 C 164 - 247 Jmol OpenAstexViewer
preSET_CXC 559 - 590 4MI0 A 559 - 590 Jmol OpenAstexViewer
4MI5 A 564 - 595 Jmol OpenAstexViewer
5HYN A 559 - 590 Jmol OpenAstexViewer
F 559 - 590 Jmol OpenAstexViewer
K 559 - 590 Jmol OpenAstexViewer
Q 559 - 590 Jmol OpenAstexViewer
5LS6 A 559 - 590 Jmol OpenAstexViewer
D 559 - 590 Jmol OpenAstexViewer
G 559 - 590 Jmol OpenAstexViewer
J 559 - 590 Jmol OpenAstexViewer
5WG6 A 559 - 590 Jmol OpenAstexViewer
C 559 - 590 Jmol OpenAstexViewer
6C23 K 559 - 590 Jmol OpenAstexViewer
6C24 K 559 - 590 Jmol OpenAstexViewer
SET 623 - 727 4MI0 A 623 - 727 Jmol OpenAstexViewer
4MI5 A 628 - 732 Jmol OpenAstexViewer
5HYN A 623 - 727 Jmol OpenAstexViewer
F 623 - 727 Jmol OpenAstexViewer
K 623 - 727 Jmol OpenAstexViewer
Q 623 - 727 Jmol OpenAstexViewer
5LS6 A 623 - 727 Jmol OpenAstexViewer
D 623 - 727 Jmol OpenAstexViewer
G 623 - 727 Jmol OpenAstexViewer
J 623 - 727 Jmol OpenAstexViewer
5WG6 A 623 - 727 Jmol OpenAstexViewer
C 623 - 727 Jmol OpenAstexViewer
6C23 K 623 - 727 Jmol OpenAstexViewer
6C24 K 623 - 727 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.