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19  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EZH2_HUMAN (Q15910)

Summary

This is the summary of UniProt entry EZH2_HUMAN (Q15910).

Description: Histone-lysine N-methyltransferase EZH2 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 746 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 7
disorder n/a 9 11
Pfam EZH2_WD-Binding 39 68
Pfam PRC2_HTH_1 158 249
disorder n/a 177 219
low_complexity n/a 183 192
disorder n/a 221 222
disorder n/a 238 277
low_complexity n/a 238 252
disorder n/a 305 313
disorder n/a 315 322
disorder n/a 335 432
low_complexity n/a 349 366
low_complexity n/a 385 409
disorder n/a 478 491
Pfam preSET_CXC 559 590
Pfam SET 623 727

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15910. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL
50
51
ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT
100
101
LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI
150
151
KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPEEREEKQ
200
201
KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ
250
251
QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH
300
301
ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP
350
351
GGRRRGRLPN NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK
400
401
KDETSSSSEA NSRCQTPIKM KPNIEPPENV EWSGAEASMF RVLIGTYYDN
450
451
FCAIARLIGT KTCRQVYEFR VKESSIIAPA PAEDVDTPPR KKKRKHRLWA
500
501
AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ NFCEKFCQCS
550
551
SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS
600
601
CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE
650
651
ADRRGKVYDK YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM
700
701
MVNGDHRIGI FAKRAIQTGE ELFFDYRYSQ ADALKYVGIE REMEIP    
746
 

Show the unformatted sequence.

Checksums:
CRC64:1B5029EB9D509BE5
MD5:6b234210507cf6ae2336d0f32b29e201

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EZH2_WD-Binding 39 - 66 5WG6 C 39 - 66 Show 3D Structure View in InterPro
39 - 68 5HYN A 39 - 68 Show 3D Structure View in InterPro
F 39 - 68 Show 3D Structure View in InterPro
K 39 - 68 Show 3D Structure View in InterPro
Q 39 - 68 Show 3D Structure View in InterPro
5LS6 A 39 - 68 Show 3D Structure View in InterPro
D 39 - 68 Show 3D Structure View in InterPro
G 39 - 68 Show 3D Structure View in InterPro
J 39 - 68 Show 3D Structure View in InterPro
5WG6 A 39 - 68 Show 3D Structure View in InterPro
6C23 C 39 - 68 Show 3D Structure View in InterPro
6C24 C 39 - 68 Show 3D Structure View in InterPro
6U4Y A 39 - 68 Show 3D Structure View in InterPro
B 39 - 68 Show 3D Structure View in InterPro
C 39 - 68 Show 3D Structure View in InterPro
40 - 66 5H17 B 40 - 66 Show 3D Structure View in InterPro
40 - 68 5GSA C 40 - 68 Show 3D Structure View in InterPro
D 40 - 68 Show 3D Structure View in InterPro
5H14 C 40 - 68 Show 3D Structure View in InterPro
D 40 - 68 Show 3D Structure View in InterPro
5H15 C 40 - 68 Show 3D Structure View in InterPro
D 40 - 68 Show 3D Structure View in InterPro
5H19 B 40 - 68 Show 3D Structure View in InterPro
5H24 C 40 - 68 Show 3D Structure View in InterPro
D 40 - 68 Show 3D Structure View in InterPro
5H25 C 40 - 68 Show 3D Structure View in InterPro
D 40 - 68 Show 3D Structure View in InterPro
41 - 68 5U5T D 41 - 68 Show 3D Structure View in InterPro
5U62 D 41 - 68 Show 3D Structure View in InterPro
5WUK B 41 - 68 Show 3D Structure View in InterPro
43 - 68 5U5T C 43 - 68 Show 3D Structure View in InterPro
5U62 C 43 - 68 Show 3D Structure View in InterPro
PRC2_HTH_1 158 - 247 5HYN K 158 - 247 Show 3D Structure View in InterPro
6C23 C 158 - 247 Show 3D Structure View in InterPro
158 - 248 5HYN F 158 - 248 Show 3D Structure View in InterPro
Q 158 - 248 Show 3D Structure View in InterPro
158 - 249 5HYN A 158 - 249 Show 3D Structure View in InterPro
5LS6 A 158 - 249 Show 3D Structure View in InterPro
D 158 - 249 Show 3D Structure View in InterPro
G 158 - 249 Show 3D Structure View in InterPro
J 158 - 249 Show 3D Structure View in InterPro
163 - 249 6U4Y A 163 - 249 Show 3D Structure View in InterPro
B 163 - 249 Show 3D Structure View in InterPro
C 163 - 249 Show 3D Structure View in InterPro
164 - 247 6C24 C 164 - 247 Show 3D Structure View in InterPro
preSET_CXC 559 - 590 4MI0 A 559 - 590 Show 3D Structure View in InterPro
4MI5 A 564 - 595 Show 3D Structure View in InterPro
5HYN A 559 - 590 Show 3D Structure View in InterPro
F 559 - 590 Show 3D Structure View in InterPro
K 559 - 590 Show 3D Structure View in InterPro
Q 559 - 590 Show 3D Structure View in InterPro
5LS6 A 559 - 590 Show 3D Structure View in InterPro
D 559 - 590 Show 3D Structure View in InterPro
G 559 - 590 Show 3D Structure View in InterPro
J 559 - 590 Show 3D Structure View in InterPro
5WG6 A 559 - 590 Show 3D Structure View in InterPro
C 559 - 590 Show 3D Structure View in InterPro
6C23 K 559 - 590 Show 3D Structure View in InterPro
6C24 K 559 - 590 Show 3D Structure View in InterPro
7AT8 A 577 - 608 Show 3D Structure View in InterPro
SET 623 - 727 4MI0 A 623 - 727 Show 3D Structure View in InterPro
4MI5 A 628 - 732 Show 3D Structure View in InterPro
5HYN A 623 - 727 Show 3D Structure View in InterPro
F 623 - 727 Show 3D Structure View in InterPro
K 623 - 727 Show 3D Structure View in InterPro
Q 623 - 727 Show 3D Structure View in InterPro
5LS6 A 623 - 727 Show 3D Structure View in InterPro
D 623 - 727 Show 3D Structure View in InterPro
G 623 - 727 Show 3D Structure View in InterPro
J 623 - 727 Show 3D Structure View in InterPro
5WG6 A 623 - 727 Show 3D Structure View in InterPro
C 623 - 727 Show 3D Structure View in InterPro
6C23 K 623 - 727 Show 3D Structure View in InterPro
6C24 K 623 - 727 Show 3D Structure View in InterPro
7AT8 A 641 - 745 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;