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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PKN2_HUMAN (Q16513)

Summary

This is the summary of UniProt entry PKN2_HUMAN (Q16513).

Description: Serine/threonine-protein kinase N2 EC=2.7.11.13
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 984 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 7 12
low_complexity n/a 44 64
disorder n/a 47 48
Pfam HR1 49 111
disorder n/a 67 68
coiled_coil n/a 86 106
low_complexity n/a 86 104
disorder n/a 111 137
Pfam HR1 137 204
coiled_coil n/a 138 158
disorder n/a 158 168
disorder n/a 170 178
Pfam HR1 218 285
disorder n/a 254 256
disorder n/a 309 317
disorder n/a 353 356
low_complexity n/a 364 381
disorder n/a 366 372
disorder n/a 379 382
disorder n/a 531 537
low_complexity n/a 539 549
disorder n/a 541 542
disorder n/a 545 553
disorder n/a 560 586
low_complexity n/a 571 579
disorder n/a 588 589
disorder n/a 592 595
disorder n/a 607 612
disorder n/a 616 639
Pfam Pkinase 657 916
low_complexity n/a 889 900
disorder n/a 902 904
Pfam Pkinase_C 937 979
disorder n/a 949 954
disorder n/a 957 965

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16513. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASNPERGEI LLTELQGDSR SLPFSENVSA VQKLDFSDTM VQQKLDDIKD
50
51
RIKREIRKEL KIKEGAENLR KVTTDKKSLA YVDNILKKSN KKLEELHHKL
100
101
QELNAHIVVS DPEDITDCPR TPDTPNNDPR CSTSNNRLKA LQKQLDIELK
150
151
VKQGAENMIQ MYSNGSSKDR KLHGTAQQLL QDSKTKIEVI RMQILQAVQT
200
201
NELAFDNAKP VISPLELRME ELRHHFRIEF AVAEGAKNVM KLLGSGKVTD
250
251
RKALSEAQAR FNESSQKLDL LKYSLEQRLN EVPKNHPKSR IIIEELSLVA
300
301
ASPTLSPRQS MISTQNQYST LSKPAALTGT LEVRLMGCQD ILENVPGRSK
350
351
ATSVALPGWS PSETRSSFMS RTSKSKSGSS RNLLKTDDLS NDVCAVLKLD
400
401
NTVVGQTSWK PISNQSWDQK FTLELDRSRE LEISVYWRDW RSLCAVKFLR
450
451
LEDFLDNQRH GMCLYLEPQG TLFAEVTFFN PVIERRPKLQ RQKKIFSKQQ
500
501
GKTFLRAPQM NINIATWGRL VRRAIPTVNH SGTFSPQAPV PTTVPVVDVR
550
551
IPQLAPPASD STVTKLDFDL EPEPPPAPPR ASSLGEIDES SELRVLDIPG
600
601
QDSETVFDIQ NDRNSILPKS QSEYKPDTPQ SGLEYSGIQE LEDRRSQQRF
650
651
QFNLQDFRCC AVLGRGHFGK VLLAEYKNTN EMFAIKALKK GDIVARDEVD
700
701
SLMCEKRIFE TVNSVRHPFL VNLFACFQTK EHVCFVMEYA AGGDLMMHIH
750
751
TDVFSEPRAV FYAACVVLGL QYLHEHKIVY RDLKLDNLLL DTEGFVKIAD
800
801
FGLCKEGMGY GDRTSTFCGT PEFLAPEVLT ETSYTRAVDW WGLGVLIYEM
850
851
LVGESPFPGD DEEEVFDSIV NDEVRYPRFL STEAISIMRR LLRRNPERRL
900
901
GASEKDAEDV KKHPFFRLID WSALMDKKVK PPFIPTIRGR EDVSNFDDEF
950
951
TSEAPILTPP REPRILSEEE QEMFRDFDYI ADWC                 
984
 

Show the unformatted sequence.

Checksums:
CRC64:687EC417A0F51C1D
MD5:8014f731ebb9cd8202f732ab6628d989

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 657 - 916 4CRS A 657 - 916 Show 3D Structure View in InterPro
Pkinase_C 937 - 979 4CRS A 937 - 979 Show 3D Structure View in InterPro
970 - 979 6CCY A 468 - 477 Show 3D Structure View in InterPro
973 - 979 4RRV B 13 - 19 Show 3D Structure View in InterPro
6GBE B 120 - 126 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;