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237  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MK14_HUMAN (Q16539)

Summary

This is the summary of UniProt entry MK14_HUMAN (Q16539).

Description: Mitogen-activated protein kinase 14
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 360 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Pkinase 24 308
low_complexity n/a 298 311
disorder n/a 319 322
disorder n/a 353 354
disorder n/a 356 360

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16539. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV
50
51
AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN
100
101
DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD
150
151
LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY
200
201
NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG TPGAELLKKI
250
251
SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
300
301
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP
350
351
PPLDQEEMES                                            
360
 

Show the unformatted sequence.

Checksums:
CRC64:286C81D0487618B3
MD5:4f35ee5c7e10d2f8f66e8580cd2f9708

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 24 - 308 1A9U A 24 - 308 Jmol OpenAstexViewer
1BL6 A 24 - 308 Jmol OpenAstexViewer
1BL7 A 24 - 308 Jmol OpenAstexViewer
1BMK A 24 - 308 Jmol OpenAstexViewer
1DI9 A 24 - 308 Jmol OpenAstexViewer
1IAN A 24 - 308 Jmol OpenAstexViewer
1KV1 A 24 - 308 Jmol OpenAstexViewer
1KV2 A 24 - 308 Jmol OpenAstexViewer
1M7Q A 24 - 308 Jmol OpenAstexViewer
1OUK A 24 - 308 Jmol OpenAstexViewer
1OUY A 24 - 308 Jmol OpenAstexViewer
1OVE A 24 - 308 Jmol OpenAstexViewer
1OZ1 A 24 - 308 Jmol OpenAstexViewer
1R39 A 24 - 308 Jmol OpenAstexViewer
1R3C A 24 - 308 Jmol OpenAstexViewer
1W7H A 24 - 308 Jmol OpenAstexViewer
1W82 A 24 - 308 Jmol OpenAstexViewer
1W83 A 24 - 308 Jmol OpenAstexViewer
1W84 A 24 - 308 Jmol OpenAstexViewer
1WBN A 24 - 308 Jmol OpenAstexViewer
1WBO A 24 - 308 Jmol OpenAstexViewer
1WBS A 24 - 308 Jmol OpenAstexViewer
1WBT A 24 - 308 Jmol OpenAstexViewer
1WBV A 24 - 308 Jmol OpenAstexViewer
1WBW A 24 - 308 Jmol OpenAstexViewer
1WFC A 24 - 308 Jmol OpenAstexViewer
1YQJ A 24 - 308 Jmol OpenAstexViewer
1ZYJ A 24 - 308 Jmol OpenAstexViewer
1ZZ2 A 24 - 308 Jmol OpenAstexViewer
1ZZL A 24 - 308 Jmol OpenAstexViewer
2BAJ A 24 - 308 Jmol OpenAstexViewer
2BAK A 24 - 308 Jmol OpenAstexViewer
2BAL A 24 - 308 Jmol OpenAstexViewer
2BAQ A 24 - 308 Jmol OpenAstexViewer
2FSL X 24 - 308 Jmol OpenAstexViewer
2FSM X 24 - 308 Jmol OpenAstexViewer
2FSO X 24 - 308 Jmol OpenAstexViewer
2FST X 24 - 308 Jmol OpenAstexViewer
2GFS A 24 - 308 Jmol OpenAstexViewer
2I0H A 24 - 308 Jmol OpenAstexViewer
2LGC A 24 - 308 Jmol OpenAstexViewer
2NPQ A 24 - 308 Jmol OpenAstexViewer
2OKR A 24 - 308 Jmol OpenAstexViewer
D 24 - 308 Jmol OpenAstexViewer
2ONL A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
2QD9 A 24 - 308 Jmol OpenAstexViewer
2RG5 A 24 - 308 Jmol OpenAstexViewer
2RG6 A 24 - 308 Jmol OpenAstexViewer
2Y8O A 24 - 308 Jmol OpenAstexViewer
2YIS A 24 - 308 Jmol OpenAstexViewer
2YIW A 24 - 308 Jmol OpenAstexViewer
2YIX A 24 - 308 Jmol OpenAstexViewer
2ZAZ A 24 - 308 Jmol OpenAstexViewer
2ZB0 A 24 - 308 Jmol OpenAstexViewer
2ZB1 A 24 - 308 Jmol OpenAstexViewer
3BV2 A 24 - 308 Jmol OpenAstexViewer
3BV3 A 24 - 308 Jmol OpenAstexViewer
3BX5 A 24 - 308 Jmol OpenAstexViewer
3C5U A 24 - 308 Jmol OpenAstexViewer
3CTQ A 24 - 308 Jmol OpenAstexViewer
3D7Z A 24 - 308 Jmol OpenAstexViewer
3D83 A 24 - 308 Jmol OpenAstexViewer
3DS6 A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
C 24 - 308 Jmol OpenAstexViewer
D 24 - 308 Jmol OpenAstexViewer
3DT1 A 24 - 308 Jmol OpenAstexViewer
3E92 A 24 - 308 Jmol OpenAstexViewer
3E93 A 24 - 308 Jmol OpenAstexViewer
3FC1 X 24 - 308 Jmol OpenAstexViewer
3FI4 A 24 - 308 Jmol OpenAstexViewer
3FKL A 24 - 308 Jmol OpenAstexViewer
3FKN A 24 - 308 Jmol OpenAstexViewer
3FKO A 24 - 308 Jmol OpenAstexViewer
3FL4 A 24 - 308 Jmol OpenAstexViewer
3FLN C 24 - 308 Jmol OpenAstexViewer
3FLQ A 24 - 308 Jmol OpenAstexViewer
3FLS A 24 - 308 Jmol OpenAstexViewer
3FLW A 24 - 308 Jmol OpenAstexViewer
3FLY A 24 - 308 Jmol OpenAstexViewer
3FLZ A 24 - 308 Jmol OpenAstexViewer
3FMH A 24 - 308 Jmol OpenAstexViewer
3FMJ A 24 - 308 Jmol OpenAstexViewer
3FMK A 24 - 308 Jmol OpenAstexViewer
3FML A 24 - 308 Jmol OpenAstexViewer
3FMM A 24 - 308 Jmol OpenAstexViewer
3FMN A 24 - 308 Jmol OpenAstexViewer
3FSF A 24 - 308 Jmol OpenAstexViewer
3FSK A 24 - 308 Jmol OpenAstexViewer
3GC7 A 24 - 308 Jmol OpenAstexViewer
3GCP A 24 - 308 Jmol OpenAstexViewer
3GCQ A 24 - 308 Jmol OpenAstexViewer
3GCS A 24 - 308 Jmol OpenAstexViewer
3GCU A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
3GCV A 24 - 308 Jmol OpenAstexViewer
3GFE A 24 - 308 Jmol OpenAstexViewer
3GI3 A 24 - 308 Jmol OpenAstexViewer
3HA8 A 24 - 308 Jmol OpenAstexViewer
3HEC A 24 - 308 Jmol OpenAstexViewer
3HEG A 24 - 308 Jmol OpenAstexViewer
3HL7 A 23 - 307 Jmol OpenAstexViewer
3HLL A 24 - 308 Jmol OpenAstexViewer
3HP2 A 24 - 308 Jmol OpenAstexViewer
3HP5 A 24 - 308 Jmol OpenAstexViewer
3HRB A 24 - 308 Jmol OpenAstexViewer
3HUB A 24 - 308 Jmol OpenAstexViewer
3HUC A 24 - 308 Jmol OpenAstexViewer
3HV3 A 24 - 308 Jmol OpenAstexViewer
3HV4 A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
3HV5 A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
3HV6 A 24 - 308 Jmol OpenAstexViewer
3HV7 A 24 - 308 Jmol OpenAstexViewer
3HVC A 24 - 308 Jmol OpenAstexViewer
3IPH A 24 - 308 Jmol OpenAstexViewer
3ITZ A 24 - 308 Jmol OpenAstexViewer
3IW5 A 24 - 308 Jmol OpenAstexViewer
3IW6 A 24 - 308 Jmol OpenAstexViewer
3IW7 A 24 - 308 Jmol OpenAstexViewer
3IW8 A 24 - 308 Jmol OpenAstexViewer
3K3I A 24 - 308 Jmol OpenAstexViewer
3K3J A 24 - 308 Jmol OpenAstexViewer
3KF7 A 24 - 308 Jmol OpenAstexViewer
3KQ7 A 24 - 308 Jmol OpenAstexViewer
3L8S A 24 - 308 Jmol OpenAstexViewer
3L8X A 24 - 308 Jmol OpenAstexViewer
3LFA A 24 - 308 Jmol OpenAstexViewer
3LFB A 24 - 308 Jmol OpenAstexViewer
3LFC A 24 - 308 Jmol OpenAstexViewer
3LFD A 24 - 308 Jmol OpenAstexViewer
3LFE A 24 - 308 Jmol OpenAstexViewer
3LFF A 24 - 308 Jmol OpenAstexViewer
3LHJ A 24 - 308 Jmol OpenAstexViewer
3MGY A 24 - 308 Jmol OpenAstexViewer
3MH0 A 24 - 308 Jmol OpenAstexViewer
3MH1 A 24 - 308 Jmol OpenAstexViewer
3MH2 A 24 - 308 Jmol OpenAstexViewer
3MH3 A 24 - 308 Jmol OpenAstexViewer
3MPA A 24 - 308 Jmol OpenAstexViewer
3MPT A 24 - 308 Jmol OpenAstexViewer
3MVL A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
3MVM A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
3MW1 A 24 - 308 Jmol OpenAstexViewer
3NEW A 24 - 308 Jmol OpenAstexViewer
3NNU A 24 - 308 Jmol OpenAstexViewer
3NNV A 24 - 308 Jmol OpenAstexViewer
3NNW A 24 - 308 Jmol OpenAstexViewer
3NNX A 24 - 308 Jmol OpenAstexViewer
3NWW A 24 - 308 Jmol OpenAstexViewer
3O8P A 24 - 308 Jmol OpenAstexViewer
3O8T A 24 - 308 Jmol OpenAstexViewer
3O8U A 24 - 308 Jmol OpenAstexViewer
3OBG A 24 - 308 Jmol OpenAstexViewer
3OBJ A 24 - 308 Jmol OpenAstexViewer
3OC1 A 24 - 308 Jmol OpenAstexViewer
3OCG A 24 - 308 Jmol OpenAstexViewer
3OD6 X 24 - 308 Jmol OpenAstexViewer
3ODY X 24 - 308 Jmol OpenAstexViewer
3ODZ X 24 - 308 Jmol OpenAstexViewer
3OEF X 24 - 308 Jmol OpenAstexViewer
3PG3 A 24 - 308 Jmol OpenAstexViewer
3QUD A 24 - 308 Jmol OpenAstexViewer
3QUE A 24 - 308 Jmol OpenAstexViewer
3RIN A 24 - 308 Jmol OpenAstexViewer
3ROC A 24 - 308 Jmol OpenAstexViewer
3S3I A 24 - 308 Jmol OpenAstexViewer
3S4Q A 24 - 308 Jmol OpenAstexViewer
3U8W A 24 - 308 Jmol OpenAstexViewer
3UVP A 24 - 308 Jmol OpenAstexViewer
3UVQ A 24 - 308 Jmol OpenAstexViewer
3UVR A 24 - 308 Jmol OpenAstexViewer
3ZS5 A 24 - 308 Jmol OpenAstexViewer
3ZSG A 24 - 308 Jmol OpenAstexViewer
3ZSH A 24 - 308 Jmol OpenAstexViewer
3ZSI A 24 - 308 Jmol OpenAstexViewer
3ZYA A 24 - 308 Jmol OpenAstexViewer
4A9Y A 24 - 308 Jmol OpenAstexViewer
4AA0 A 24 - 308 Jmol OpenAstexViewer
4AA4 A 24 - 308 Jmol OpenAstexViewer
4AA5 A 24 - 308 Jmol OpenAstexViewer
4AAC A 24 - 308 Jmol OpenAstexViewer
4DLI A 24 - 308 Jmol OpenAstexViewer
4DLJ A 24 - 308 Jmol OpenAstexViewer
4E5A X 24 - 308 Jmol OpenAstexViewer
4E5B A 24 - 308 Jmol OpenAstexViewer
4E6A A 24 - 308 Jmol OpenAstexViewer
4E6C A 24 - 308 Jmol OpenAstexViewer
4E8A A 24 - 308 Jmol OpenAstexViewer
4EH2 A 24 - 308 Jmol OpenAstexViewer
4EH3 A 24 - 308 Jmol OpenAstexViewer
4EH4 A 24 - 308 Jmol OpenAstexViewer
4EH5 A 24 - 308 Jmol OpenAstexViewer
4EH6 A 24 - 308 Jmol OpenAstexViewer
4EH7 A 24 - 308 Jmol OpenAstexViewer
4EH8 A 24 - 308 Jmol OpenAstexViewer
4EH9 A 24 - 308 Jmol OpenAstexViewer
4EHV A 24 - 308 Jmol OpenAstexViewer
4EWQ A 24 - 308 Jmol OpenAstexViewer
4F9W A 24 - 308 Jmol OpenAstexViewer
4F9Y A 24 - 308 Jmol OpenAstexViewer
4FA2 A 24 - 308 Jmol OpenAstexViewer
4GEO A 24 - 308 Jmol OpenAstexViewer
4KIN A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
C 24 - 308 Jmol OpenAstexViewer
D 24 - 308 Jmol OpenAstexViewer
4KIP A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
4KIQ A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
C 24 - 308 Jmol OpenAstexViewer
D 24 - 308 Jmol OpenAstexViewer
4L8M A 24 - 308 Jmol OpenAstexViewer
4R3C A 24 - 308 Jmol OpenAstexViewer
4ZTH A 24 - 308 Jmol OpenAstexViewer
5ETA A 24 - 308 Jmol OpenAstexViewer
B 24 - 308 Jmol OpenAstexViewer
5ETC A 24 - 308 Jmol OpenAstexViewer
5ETF A 24 - 308 Jmol OpenAstexViewer
5ETI A 24 - 308 Jmol OpenAstexViewer
5ML5 A 24 - 308 Jmol OpenAstexViewer
5MTX A 24 - 308 Jmol OpenAstexViewer
5MTY A 24 - 308 Jmol OpenAstexViewer
5MZ3 A 24 - 308 Jmol OpenAstexViewer
5N63 A 24 - 308 Jmol OpenAstexViewer
5N64 A 24 - 308 Jmol OpenAstexViewer
5N65 A 24 - 308 Jmol OpenAstexViewer
5N66 A 24 - 308 Jmol OpenAstexViewer
5N67 A 24 - 308 Jmol OpenAstexViewer
5N68 A 24 - 308 Jmol OpenAstexViewer
5O8U A 24 - 308 Jmol OpenAstexViewer
5O8V A 24 - 308 Jmol OpenAstexViewer
5OMG A 24 - 308 Jmol OpenAstexViewer
5OMH A 24 - 308 Jmol OpenAstexViewer
5TBE A 24 - 308 Jmol OpenAstexViewer
5TCO A 24 - 308 Jmol OpenAstexViewer
5WJJ A 24 - 308 Jmol OpenAstexViewer
5XYX A 24 - 308 Jmol OpenAstexViewer
5XYY A 24 - 308 Jmol OpenAstexViewer
6ANL A 24 - 308 Jmol OpenAstexViewer
6HWT A 24 - 308 Jmol OpenAstexViewer
6HWU A 24 - 308 Jmol OpenAstexViewer
6HWV A 24 - 308 Jmol OpenAstexViewer
6M95 A 24 - 308 Jmol OpenAstexViewer
6M9L A 24 - 308 Jmol OpenAstexViewer
6OHD A 24 - 308 Jmol OpenAstexViewer
6SFI A 24 - 308 Jmol OpenAstexViewer
6SFJ A 24 - 308 Jmol OpenAstexViewer
6SFK A 24 - 308 Jmol OpenAstexViewer
6SFO A 24 - 308 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.