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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FRDA_HUMAN (Q16595)

Summary

This is the summary of UniProt entry FRDA_HUMAN (Q16595).

Description: Frataxin, mitochondrial EC=1.16.3.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 210 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 21
disorder n/a 19 28
disorder n/a 48 54
disorder n/a 89 91
Pfam Frataxin_Cyay 90 198
low_complexity n/a 183 203

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16595. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWTLGRRAVA GLLASPSPAQ AQTLTRVPRP AELAPLCGRR GLRTDIDATC
50
51
TPRRASSNQR GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE
100
101
ETLDSLAEFF EDLADKPYTF EDYDVSFGSG VLTVKLGGDL GTYVINKQTP
150
151
NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV SLHELLAAEL TKALKTKLDL
200
201
SSLAYSGKDA                                            
210
 

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Checksums:
CRC64:ECC81738779308CF
MD5:994262904b50b2cfb188d06633a33c32

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Frataxin_Cyay 90 - 198 1EKG A 90 - 198 Jmol OpenAstexViewer
1LY7 A 90 - 198 Jmol OpenAstexViewer
3S4M A 90 - 198 Jmol OpenAstexViewer
3S5D A 90 - 198 Jmol OpenAstexViewer
3S5E A 90 - 198 Jmol OpenAstexViewer
3S5F A 90 - 198 Jmol OpenAstexViewer
B 90 - 198 Jmol OpenAstexViewer
3T3J A 90 - 198 Jmol OpenAstexViewer
3T3K A 90 - 198 Jmol OpenAstexViewer
3T3L A 90 - 198 Jmol OpenAstexViewer
3T3T A 90 - 198 Jmol OpenAstexViewer
B 90 - 198 Jmol OpenAstexViewer
C 90 - 198 Jmol OpenAstexViewer
D 90 - 198 Jmol OpenAstexViewer
3T3X A 90 - 198 Jmol OpenAstexViewer
B 90 - 198 Jmol OpenAstexViewer
5KZ5 A 90 - 198 Jmol OpenAstexViewer
B 90 - 198 Jmol OpenAstexViewer
C 90 - 198 Jmol OpenAstexViewer
D 90 - 198 Jmol OpenAstexViewer
E 90 - 198 Jmol OpenAstexViewer
F 90 - 198 Jmol OpenAstexViewer
G 90 - 198 Jmol OpenAstexViewer
H 90 - 198 Jmol OpenAstexViewer
I 90 - 198 Jmol OpenAstexViewer
J 90 - 198 Jmol OpenAstexViewer
K 90 - 198 Jmol OpenAstexViewer
L 90 - 198 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.