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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FSCN1_HUMAN (Q16658)

Summary

This is the summary of UniProt entry FSCN1_HUMAN (Q16658).

Description: Fascin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 493 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Fascin 20 134
Pfam Fascin 142 256
disorder n/a 199 200
disorder n/a 241 243
Pfam Fascin 268 378
disorder n/a 274 295
Pfam Fascin 391 493

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16658. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ
50
51
PPDEAGSAAV CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR
100
101
WSLQSEAHRR YFGGTEDRLS CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK
150
151
RYAHLSARPA DEIAVDRDVP WGVDSLITLA FQDQRYSVQT ADHRFLRHDG
200
201
RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL KAGKATKVGK
250
251
DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR
300
301
DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS
350
351
NGKFVTSKKN GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV
400
401
TGTLDANRSS YDVFQLEFND GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD
450
451
FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA SAETVDPASL WEY       
493
 

Show the unformatted sequence.

Checksums:
CRC64:C1453714BED6109A
MD5:74752ac735567b51f435866c8b2db26d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Fascin 142 - 256 1DFC A 1142 - 1256 Show 3D Structure View in InterPro
B 2142 - 2256 Show 3D Structure View in InterPro
3LLP A 142 - 256 Show 3D Structure View in InterPro
B 142 - 256 Show 3D Structure View in InterPro
3P53 A 142 - 256 Show 3D Structure View in InterPro
B 142 - 256 Show 3D Structure View in InterPro
4GOV A 142 - 256 Show 3D Structure View in InterPro
B 142 - 256 Show 3D Structure View in InterPro
4GOY A 142 - 256 Show 3D Structure View in InterPro
B 142 - 256 Show 3D Structure View in InterPro
4GP0 A 142 - 256 Show 3D Structure View in InterPro
B 142 - 256 Show 3D Structure View in InterPro
4GP3 A 142 - 256 Show 3D Structure View in InterPro
B 142 - 256 Show 3D Structure View in InterPro
6B0T A 142 - 256 Show 3D Structure View in InterPro
B 142 - 256 Show 3D Structure View in InterPro
C 142 - 256 Show 3D Structure View in InterPro
D 142 - 256 Show 3D Structure View in InterPro
E 142 - 256 Show 3D Structure View in InterPro
F 142 - 256 Show 3D Structure View in InterPro
6I0Z A 142 - 256 Show 3D Structure View in InterPro
B 142 - 256 Show 3D Structure View in InterPro
6I10 A 142 - 256 Show 3D Structure View in InterPro
6I11 A 142 - 256 Show 3D Structure View in InterPro
6I12 A 142 - 256 Show 3D Structure View in InterPro
6I13 A 142 - 256 Show 3D Structure View in InterPro
6I14 A 142 - 256 Show 3D Structure View in InterPro
6I15 A 142 - 256 Show 3D Structure View in InterPro
6I16 A 142 - 256 Show 3D Structure View in InterPro
6I17 A 142 - 256 Show 3D Structure View in InterPro
6I18 A 142 - 256 Show 3D Structure View in InterPro
20 - 134 1DFC A 1020 - 1134 Show 3D Structure View in InterPro
B 2020 - 2134 Show 3D Structure View in InterPro
3LLP A 20 - 134 Show 3D Structure View in InterPro
B 20 - 134 Show 3D Structure View in InterPro
3P53 A 20 - 134 Show 3D Structure View in InterPro
B 20 - 134 Show 3D Structure View in InterPro
4GOV A 20 - 134 Show 3D Structure View in InterPro
B 20 - 134 Show 3D Structure View in InterPro
4GOY A 20 - 134 Show 3D Structure View in InterPro
B 20 - 134 Show 3D Structure View in InterPro
4GP0 A 20 - 134 Show 3D Structure View in InterPro
B 20 - 134 Show 3D Structure View in InterPro
4GP3 A 20 - 134 Show 3D Structure View in InterPro
B 20 - 134 Show 3D Structure View in InterPro
6B0T A 20 - 134 Show 3D Structure View in InterPro
B 20 - 134 Show 3D Structure View in InterPro
C 20 - 134 Show 3D Structure View in InterPro
D 20 - 134 Show 3D Structure View in InterPro
E 20 - 134 Show 3D Structure View in InterPro
F 20 - 134 Show 3D Structure View in InterPro
6I0Z A 20 - 134 Show 3D Structure View in InterPro
B 20 - 134 Show 3D Structure View in InterPro
6I10 A 20 - 134 Show 3D Structure View in InterPro
6I11 A 20 - 134 Show 3D Structure View in InterPro
6I12 A 20 - 134 Show 3D Structure View in InterPro
6I13 A 20 - 134 Show 3D Structure View in InterPro
6I14 A 20 - 134 Show 3D Structure View in InterPro
6I15 A 20 - 134 Show 3D Structure View in InterPro
6I16 A 20 - 134 Show 3D Structure View in InterPro
6I17 A 20 - 134 Show 3D Structure View in InterPro
6I18 A 20 - 134 Show 3D Structure View in InterPro
268 - 378 1DFC A 1268 - 1378 Show 3D Structure View in InterPro
B 2268 - 2378 Show 3D Structure View in InterPro
3LLP A 268 - 378 Show 3D Structure View in InterPro
B 268 - 378 Show 3D Structure View in InterPro
3P53 A 268 - 378 Show 3D Structure View in InterPro
B 268 - 378 Show 3D Structure View in InterPro
4GOV A 268 - 378 Show 3D Structure View in InterPro
B 268 - 378 Show 3D Structure View in InterPro
4GOY A 268 - 378 Show 3D Structure View in InterPro
B 268 - 378 Show 3D Structure View in InterPro
4GP0 A 268 - 378 Show 3D Structure View in InterPro
B 268 - 378 Show 3D Structure View in InterPro
4GP3 A 268 - 378 Show 3D Structure View in InterPro
B 268 - 378 Show 3D Structure View in InterPro
6B0T A 268 - 378 Show 3D Structure View in InterPro
B 268 - 378 Show 3D Structure View in InterPro
C 268 - 378 Show 3D Structure View in InterPro
D 268 - 378 Show 3D Structure View in InterPro
E 268 - 378 Show 3D Structure View in InterPro
F 268 - 378 Show 3D Structure View in InterPro
6I0Z A 268 - 378 Show 3D Structure View in InterPro
B 268 - 378 Show 3D Structure View in InterPro
6I10 A 268 - 378 Show 3D Structure View in InterPro
6I11 A 268 - 378 Show 3D Structure View in InterPro
6I12 A 268 - 378 Show 3D Structure View in InterPro
6I13 A 268 - 378 Show 3D Structure View in InterPro
6I14 A 268 - 378 Show 3D Structure View in InterPro
6I15 A 268 - 378 Show 3D Structure View in InterPro
6I16 A 268 - 378 Show 3D Structure View in InterPro
6I17 A 268 - 378 Show 3D Structure View in InterPro
6I18 A 268 - 378 Show 3D Structure View in InterPro
391 - 493 1DFC A 1391 - 1493 Show 3D Structure View in InterPro
B 2391 - 2493 Show 3D Structure View in InterPro
3LLP A 391 - 493 Show 3D Structure View in InterPro
B 391 - 493 Show 3D Structure View in InterPro
3P53 A 391 - 493 Show 3D Structure View in InterPro
B 391 - 493 Show 3D Structure View in InterPro
4GOV A 391 - 493 Show 3D Structure View in InterPro
B 391 - 493 Show 3D Structure View in InterPro
4GOY A 391 - 493 Show 3D Structure View in InterPro
B 391 - 493 Show 3D Structure View in InterPro
4GP0 A 391 - 493 Show 3D Structure View in InterPro
B 391 - 493 Show 3D Structure View in InterPro
4GP3 A 391 - 493 Show 3D Structure View in InterPro
B 391 - 493 Show 3D Structure View in InterPro
6B0T A 391 - 493 Show 3D Structure View in InterPro
B 391 - 493 Show 3D Structure View in InterPro
C 391 - 493 Show 3D Structure View in InterPro
D 391 - 493 Show 3D Structure View in InterPro
E 391 - 493 Show 3D Structure View in InterPro
F 391 - 493 Show 3D Structure View in InterPro
6I0Z A 391 - 493 Show 3D Structure View in InterPro
B 391 - 493 Show 3D Structure View in InterPro
6I10 A 391 - 493 Show 3D Structure View in InterPro
6I11 A 391 - 493 Show 3D Structure View in InterPro
6I12 A 391 - 493 Show 3D Structure View in InterPro
6I13 A 391 - 493 Show 3D Structure View in InterPro
6I14 A 391 - 493 Show 3D Structure View in InterPro
6I15 A 391 - 493 Show 3D Structure View in InterPro
6I16 A 391 - 493 Show 3D Structure View in InterPro
6I17 A 391 - 493 Show 3D Structure View in InterPro
6I18 A 391 - 493 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;