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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AT2B3_HUMAN (Q16720)

Summary

This is the summary of UniProt entry AT2B3_HUMAN (Q16720).

Description: Plasma membrane calcium-transporting ATPase 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1220 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 2 20
Pfam Cation_ATPase_N 51 121
disorder n/a 70 77
transmembrane n/a 109 128
disorder n/a 136 143
low_complexity n/a 142 159
transmembrane n/a 154 173
Pfam E1-E2_ATPase 190 307
low_complexity n/a 202 213
disorder n/a 243 264
disorder n/a 273 275
low_complexity n/a 293 312
disorder n/a 299 325
disorder n/a 327 328
disorder n/a 330 355
low_complexity n/a 338 349
Pfam E1-E2_ATPase 341 451
low_complexity n/a 343 357
transmembrane n/a 376 397
transmembrane n/a 417 443
Pfam Cation_ATPase 516 612
disorder n/a 532 534
disorder n/a 742 743
Pfam Hydrolase_3 764 839
disorder n/a 773 776
disorder n/a 788 792
Pfam Cation_ATPase_C 876 1058
transmembrane n/a 933 951
transmembrane n/a 971 988
transmembrane n/a 1000 1025
transmembrane n/a 1037 1058
disorder n/a 1069 1071
disorder n/a 1074 1091
coiled_coil n/a 1076 1103
low_complexity n/a 1076 1096
Pfam ATP_Ca_trans_C 1100 1146
disorder n/a 1158 1191
low_complexity n/a 1174 1184
low_complexity n/a 1199 1215
disorder n/a 1201 1220

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16720. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE
50
51
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ
100
101
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA
150
151
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN
200
201
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH
250
251
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE
300
301
KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA
350
351
NAPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR
400
401
TWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK
450
451
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA
500
501
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF
550
551
VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG
600
601
ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY
650
651
RDFSAGQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT
700
701
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE
750
751
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP
800
801
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS
850
851
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA
900
901
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF
950
951
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI
1000
1001
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV
1050
1051
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG
1100
1101
QILWFRGLNR IQTQIRVVKA FRSSLYEGLE KPESKTSIHN FMATPEFLIN
1150
1151
DYTHNIPLID DTDVDENEER LRAPPPPSPN QNNNAIDSGI YLTTHVTKSA
1200
1201
TSSVFSSSPG SPLHSVETSL                                 
1220
 

Show the unformatted sequence.

Checksums:
CRC64:03B2BA8A0A33B193
MD5:a32b8397425f91ff24a4d2233a845b67

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;