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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DGKD_HUMAN (Q16760)

Summary

This is the summary of UniProt entry DGKD_HUMAN (Q16760).

Description: Diacylglycerol kinase delta EC=2.7.1.107
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1214 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 47
low_complexity n/a 1 35
disorder n/a 51 63
Pfam PH 54 146
disorder n/a 70 71
disorder n/a 103 105
Pfam C1_1 164 216
Pfam C1_1 236 289
Pfam DAGK_cat 321 443
disorder n/a 464 466
disorder n/a 525 529
low_complexity n/a 526 532
disorder n/a 533 534
disorder n/a 553 584
disorder n/a 595 597
disorder n/a 607 608
coiled_coil n/a 617 637
disorder n/a 622 651
disorder n/a 655 677
disorder n/a 680 682
low_complexity n/a 689 707
disorder n/a 696 709
disorder n/a 711 714
Pfam DAGK_acc 763 920
disorder n/a 783 789
disorder n/a 960 961
disorder n/a 963 980
disorder n/a 1003 1014
disorder n/a 1016 1025
disorder n/a 1059 1060
disorder n/a 1067 1077
coiled_coil n/a 1069 1089
disorder n/a 1103 1105
low_complexity n/a 1121 1132
disorder n/a 1130 1138
Pfam SAM_2 1142 1206

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16760. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAAGAPPP GPPQPPPPPP PEESSDSEPE AEPGSPQKLI RKVSTSGQIR
50
51
QKTIIKEGML TKQNNSFQRS KRRYFKLRGR TLYYAKTAKS IIFDEVDLTD
100
101
ASVAESSTKN VNNSFTVITP CRKLILCADN RKEMEDWIAA LKTVQNREHF
150
151
EPTQYSMDHF SGMHNWYACS HARPTYCNVC REALSGVTSH GLSCEVCKFK
200
201
AHKRCAVRAT NNCKWTTLAS IGKDIIEDAD GIAMPHQWLE GNLPVSAKCT
250
251
VCDKTCGSVL RLQDWRCLWC KAMVHTSCKE SLLTKCPLGL CKVSVIPPTA
300
301
LNSIDSDGFW KASCPPSCTS PLLVFVNSKS GDNQGVKFLR RFKQLLNPAQ
350
351
VFDLMNGGPH LGLRLFQKFD TFRILVCGGD GSVGWVLSEI DSLNLHKQCQ
400
401
LGVLPLGTGN DLARVLGWGS ACDDDTQLPQ ILEKLERAST KMLDRWSVMA
450
451
YEAKLPRQAS SSTVTEDFSE DSEVQQILFY EDSVAAHLSK ILTSDQHSVV
500
501
ISSAKVLCET VKDFVARVGK AYEKTTESSE ESEVMAKKCS VLKEKLDSLL
550
551
KTLDDESQAS SSLPNPPPTI AEEAEDGDGS GSICGSTGDR LVASACPARP
600
601
QIFRPREQLM LRANSLKKAI RQIIEHTEKA VDEQNAQTQE QEGFVLGLSE
650
651
SEEKMDHRVC PPLSHSESFG VPKGRSQRKV SKSPCEKLIS KGSLSLGSSA
700
701
SLPPQPGSRD GLPALNTKIL YPNVRAGMSG SLPGGSVISR LLINADPFNS
750
751
EPETLEYYTE KCVMNNYFGI GLDAKISLDF NNKRDEHPEK CRSRTKNMMW
800
801
YGVLGTKELL HRTYKNLEQK VLLECDGRPI PLPSLQGIAV LNIPSYAGGT
850
851
NFWGGTKEDD TFAAPSFDDK ILEVVAVFGS MQMAVSRVIR LQHHRIAQCR
900
901
TVKISILGDE GVPVQVDGEA WVQPPGYIRI VHKNRAQTLT RDRAFESTLK
950
951
SWEDKQKCEL PRPPSCSLHP EMLSEEEATQ MDQFGQAAGV LIHSIREIAQ
1000
1001
SHRDMEQELA HAVNASSKSM DRVYGKPRTT EGLNCSFVLE MVNNFRALRS
1050
1051
ETELLLSGKM ALQLDPPQKE QLGSALAEMD RQLRRLADTP WLCQSAEPGD
1100
1101
EESVMLDLAK RSRSGKFRLV TKFKKEKNNK NKEAHSSLGA PVHLWGTEEV
1150
1151
AAWLEHLSLC EYKDIFTRHD IRGSELLHLE RRDLKDLGVT KVGHMKRILC
1200
1201
GIKELSRSAP AVEA                                       
1214
 

Show the unformatted sequence.

Checksums:
CRC64:ED114429096D2112
MD5:f5c831fd99997bd0bcd97d7e032cb4e6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1_1 236 - 286 1R79 A 28 - 78 Jmol OpenAstexViewer
SAM_2 1142 - 1206 3BQ7 A 2 - 66 Jmol OpenAstexViewer
B 2 - 66 Jmol OpenAstexViewer
C 2 - 66 Jmol OpenAstexViewer
D 2 - 66 Jmol OpenAstexViewer
E 2 - 66 Jmol OpenAstexViewer
F 2 - 66 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.