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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GLO2_HUMAN (Q16775)

Summary

This is the summary of UniProt entry GLO2_HUMAN (Q16775).

Description: Hydroxyacylglutathione hydrolase, mitochondrial {ECO:0000303|PubMed:15117945} EC=3.1.2.6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 308 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 4 31
Pfam Lactamase_B 57 140
low_complexity n/a 90 104
Pfam HAGH_C 222 303
disorder n/a 278 308

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16775. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVVGRGLLGR RSLAALGAAC ARRGLGPALL GVFCHTDLRK NLTVDEGTMK
50
51
VEVLPALTDN YMYLVIDDET KEAAIVDPVQ PQKVVDAARK HGVKLTTVLT
100
101
THHHWDHAGG NEKLVKLESG LKVYGGDDRI GALTHKITHL STLQVGSLNV
150
151
KCLATPCHTS GHICYFVSKP GGSEPPAVFT GDTLFVAGCG KFYEGTADEM
200
201
CKALLEVLGR LPPDTRVYCG HEYTINNLKF ARHVEPGNAA IREKLAWAKE
250
251
KYSIGEPTVP STLAEEFTYN PFMRVREKTV QQHAGETDPV TTMRAVRREK
300
301
DQFKMPRD                                              
308
 

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Checksums:
CRC64:64E5C214B6EC61CB
MD5:1c2f3b2d1b157c0326cc39a1d3f3dbc2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HAGH_C 222 - 303 1QH3 A 174 - 255 Show 3D Structure View in InterPro
B 174 - 255 Show 3D Structure View in InterPro
1QH5 A 174 - 255 Show 3D Structure View in InterPro
B 174 - 255 Show 3D Structure View in InterPro
Lactamase_B 57 - 140 1QH3 A 9 - 92 Show 3D Structure View in InterPro
B 9 - 92 Show 3D Structure View in InterPro
1QH5 A 9 - 92 Show 3D Structure View in InterPro
B 9 - 92 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;