Summary
This is the summary of UniProt entry K1109_HUMAN (Q2LD37).
| Description: | Transmembrane protein KIAA1109 {ECO:0000305} |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 5005 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| transmembrane | n/a | 27 | 46 |
| transmembrane | n/a | 67 | 85 |
| disorder | n/a | 163 | 187 |
| disorder | n/a | 306 | 317 |
| disorder | n/a | 622 | 624 |
| disorder | n/a | 633 | 635 |
| disorder | n/a | 675 | 676 |
| disorder | n/a | 678 | 679 |
| disorder | n/a | 687 | 689 |
| disorder | n/a | 691 | 692 |
| disorder | n/a | 694 | 726 |
| low_complexity | n/a | 696 | 715 |
| low_complexity | n/a | 766 | 778 |
| disorder | n/a | 782 | 798 |
| disorder | n/a | 1096 | 1097 |
| low_complexity | n/a | 1126 | 1137 |
| low_complexity | n/a | 1153 | 1165 |
| disorder | n/a | 1193 | 1195 |
| disorder | n/a | 1201 | 1208 |
| disorder | n/a | 1218 | 1312 |
| low_complexity | n/a | 1225 | 1239 |
| disorder | n/a | 1314 | 1316 |
| disorder | n/a | 1339 | 1370 |
| disorder | n/a | 1373 | 1383 |
| low_complexity | n/a | 1380 | 1390 |
| low_complexity | n/a | 1388 | 1401 |
| disorder | n/a | 1397 | 1425 |
| disorder | n/a | 1427 | 1456 |
| disorder | n/a | 1462 | 1463 |
| disorder | n/a | 1480 | 1481 |
| disorder | n/a | 1486 | 1495 |
| disorder | n/a | 1521 | 1547 |
| low_complexity | n/a | 1540 | 1546 |
| disorder | n/a | 1570 | 1572 |
| disorder | n/a | 1574 | 1609 |
| low_complexity | n/a | 1590 | 1606 |
| disorder | n/a | 1611 | 1612 |
| disorder | n/a | 1676 | 1714 |
| disorder | n/a | 1741 | 1747 |
| disorder | n/a | 1770 | 1798 |
| disorder | n/a | 1800 | 1810 |
| low_complexity | n/a | 1809 | 1820 |
| disorder | n/a | 1872 | 1881 |
| disorder | n/a | 1924 | 1991 |
| low_complexity | n/a | 1980 | 1994 |
| disorder | n/a | 2168 | 2192 |
| low_complexity | n/a | 2180 | 2190 |
| disorder | n/a | 2196 | 2197 |
| disorder | n/a | 2202 | 2203 |
| disorder | n/a | 2213 | 2244 |
| disorder | n/a | 2247 | 2252 |
| disorder | n/a | 2262 | 2289 |
| disorder | n/a | 2291 | 2292 |
| disorder | n/a | 2305 | 2339 |
| low_complexity | n/a | 2335 | 2348 |
| disorder | n/a | 2362 | 2387 |
| disorder | n/a | 2393 | 2394 |
| disorder | n/a | 2397 | 2428 |
| disorder | n/a | 2488 | 2501 |
| disorder | n/a | 2593 | 2617 |
| low_complexity | n/a | 2613 | 2625 |
| disorder | n/a | 2619 | 2697 |
| low_complexity | n/a | 2621 | 2636 |
| low_complexity | n/a | 2632 | 2655 |
| coiled_coil | n/a | 2635 | 2655 |
| disorder | n/a | 2724 | 2754 |
| disorder | n/a | 2756 | 2764 |
| disorder | n/a | 2849 | 2854 |
| disorder | n/a | 2910 | 2914 |
| disorder | n/a | 2923 | 2968 |
| disorder | n/a | 3004 | 3006 |
| disorder | n/a | 3013 | 3015 |
| disorder | n/a | 3044 | 3046 |
| disorder | n/a | 3136 | 3141 |
| low_complexity | n/a | 3467 | 3479 |
| disorder | n/a | 3498 | 3499 |
| disorder | n/a | 3501 | 3529 |
| disorder | n/a | 3557 | 3558 |
| disorder | n/a | 3571 | 3572 |
| disorder | n/a | 3592 | 3593 |
| disorder | n/a | 3616 | 3665 |
| disorder | n/a | 3671 | 3675 |
| disorder | n/a | 3677 | 3681 |
| disorder | n/a | 3686 | 3748 |
| low_complexity | n/a | 3716 | 3741 |
| disorder | n/a | 3757 | 3759 |
| disorder | n/a | 3771 | 3785 |
| low_complexity | n/a | 3815 | 3836 |
| disorder | n/a | 3816 | 3819 |
| disorder | n/a | 3821 | 3864 |
| disorder | n/a | 3886 | 3954 |
| low_complexity | n/a | 3921 | 3929 |
| low_complexity | n/a | 3940 | 3947 |
| disorder | n/a | 4000 | 4024 |
| low_complexity | n/a | 4023 | 4037 |
| disorder | n/a | 4026 | 4029 |
| low_complexity | n/a | 4040 | 4048 |
| disorder | n/a | 4087 | 4140 |
| low_complexity | n/a | 4117 | 4148 |
| disorder | n/a | 4172 | 4193 |
| disorder | n/a | 4287 | 4307 |
| disorder | n/a | 4314 | 4317 |
| disorder | n/a | 4326 | 4394 |
| low_complexity | n/a | 4358 | 4379 |
| Pfam | FSA_C | 4384 | 4902 |
| disorder | n/a | 4424 | 4431 |
| disorder | n/a | 4433 | 4448 |
| disorder | n/a | 4450 | 4454 |
| disorder | n/a | 4479 | 4482 |
| disorder | n/a | 4487 | 4496 |
| disorder | n/a | 4611 | 4612 |
| disorder | n/a | 4735 | 4749 |
| disorder | n/a | 4772 | 4781 |
| disorder | n/a | 4783 | 4784 |
| disorder | n/a | 4787 | 4790 |
| low_complexity | n/a | 4789 | 4800 |
| disorder | n/a | 4822 | 4825 |
| disorder | n/a | 4828 | 4837 |
| disorder | n/a | 4896 | 4902 |
| Pfam | FSA_C | 4898 | 4989 |
| disorder | n/a | 4909 | 4910 |
| low_complexity | n/a | 4992 | 5003 |
| disorder | n/a | 4994 | 5005 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q2LD37. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MDQRKNESIV PSITQLEDFL TEHNSNVVWL LVATILSCGW IIYLTYYNSR
50 51
NVGLILTLVL NRLYKHGYIH IGSFSFSVLS GKVMVREIYY ITEDMSIRIQ
100 101
DGFIIFRWWK MYNPKQKQHD PKAETRLYIT VNDFEFHVYN RSDLYGRLQE
150 151
LFGLEPTIIP PKKDDDKTRE IGRTRTQSKI ERVKVKTESQ DPTSSWRSLI
200 201
PVIKVNVSTG RLAFGNHYQP QTLCINFDDA FLTYTTKPPS SHLDQFMHIV
250 251
KGKLENVRVM LVPSPRYVGL QNDEPPRLMG EGFVVMQSND VDIYYYMDEP
300 301
GLVPEETEEN IEGEMSSEDC KLQDLPPCWG LDIVCGKGTD FNYGPWADRQ
350 351
RDCLWKFFFP PDYQVLKVSE IAQPGRPRQI LAFELRMNII ADATIDLLFT
400 401
KNRETNAVHV NVGAGSYLEI NIPMTVEENG YTPAIKGQLL HVDATTSMQY
450 451
RTLLEAEMLA FHINASYPRI WNMPQTWQCE LEVYKATYHF IFAQKNFFTD
500 501
LIQDWSSDSP PDIFSFVPYT WNFKIMFHQF EMIWAANQHN WIDCSTKQQE
550 551
NVYLAACGET LNIDFSLPFT DFVPATCNTK FSLRGEDVDL HLFLPDCHPS
600 601
KYSLFMLVKN CHPNKMIHDT GIPAECQSGQ KTVKPKWRNV TQEKSGWVEC
650 651
WTVPSVMLTI DYTWHPIYPQ KADEQLKQSL SEMEETMLSV LRPSQKTSDR
700 701
VVSSPSTSSR PPIDPSELPP DKLHVEMELS PDSQITLYGP LLNAFLCIKE
750 751
NYFGEDDMYM DFEEVISSPV LSLSTSSSSG WTAVGMENDK KENEGSAKSI
800 801
HPLALRPWDI TVLVNLYKVH GRLPVHGTTD GPECPTAFLE RLCFEMKKGF
850 851
RETMLQLILS PLNVFVSDNY QQRPPVDEVL REGHINLSGL QLRAHAMFSA
900 901
EGLPLGSDSL EYAWLIDVQA GSLTAKVTAP QLACLLEWGQ TFVFHVVCRE
950 951
YELERPKSVI ICQHGIDRRF CESKLSCIPG PCPTSDDLKY TMIRLAVDGA
1000 1001
DIYIVEHGCA TNIKMGAIRV ANCNLHNQSV GEGISAAIQD FQVRQYIEQL
1050 1051
NNCRIGLQPA VLRRAYWLEA GSANLGLITV DIALAADHHS KHEAQRHFLE
1100 1101
THDARTKRLW FLWPDDILKN KRCRNKCGCL GGCRFFGGTV TGLDFFKLEE
1150 1151
LTPSSSSAFS STSAESDMYY GQSLLQPGEW IITKEIPKII DGNVNGMKRK
1200 1201
EWENKSVGIE VERKTQHLSL QVPLRSHSSS SSSEENSSSS AAQPLLAGEK
1250 1251
ESPSSVADDH LVQKEFLHGT KRDDGQASIP TEISGNSPVS PNTQDKSVGQ
1300 1301
SPLRSPLKRQ ASVCSTRLGS TKSLTAAFYG DKQPVTVGVQ FSSDVSRSDE
1350 1351
NVLDSPKQRR SFGSFPYTPS ADSNSFHQYR SMDSSMSMAD SEAYFSAAEE
1400 1401
FEPISSDEGP GTYPGRKKKK KQTQQIDYSR GSIYHSVEGP LTGHGESIQD
1450 1451
SRTLPFKTHP SQASFVSALG GEDDVIEHLY IVEGEKTVES EQITPQQPVM
1500 1501
NCYQTYLTQF QVINWSVKHP TNKRTSKSSL HRPLDLDTPT SEESSSSFEQ
1550 1551
LSVPTFKVIK QGLTANSLLD RGMQLSGSTS NTPYTPLEKK LADNTDDETL
1600 1601
TEEWTLDQPV SQTRTTAIVE VKGTVDIVLT PLVAEALDRY IEAMVHCAST
1650 1651
RHPAAIVDDL HAKVLREAVQ NSKTTFSENL SSKQDIRGTK TEQSTIGTTN
1700 1701
QGQAQTNLTM KQDNVTIKGL QTNVSIPKVN LCLLQASVEE SPTTAPSRSV
1750 1751
THVSLVALCF DRIATQVRMN RGVVEETSNN AEPGRTSNFD RYVHATKMQP
1800 1801
QSSGSLRSNA GAEKGKEIAA KLNIHRVHGQ LRGLDTTDIG TCAITAIPFE
1850 1851
KSKVLFTLEE LDEFTFVDET DQQAVPDVTR IGPSQEKWGW IMFECGLENL
1900 1901
TIKGGRQSGA VLYNSFGIMG KASDTERGGV LTSNNSSDSP TGSGYNTDVS
1950 1951
DDNLPCDRTS PSSDLNGNSV SDEQDEGVES DDLKKDLPLM PPPPDSCSMK
2000 2001
LTIKEIWFSF AAPTNVRSHT HAFSRQLNLL STATPAVGAW LVPIDQLKSS
2050 2051
LNKLETEGTL RICAVMGCIM TEALENKSVH FPLRSKYNRL TKVARFLQEN
2100 2101
PSCLLCNILH HYLHQANYSI IDDATMSDGL PALVTLKKGL VALARQWMKF
2150 2151
IVVTPAFKGV SLHRPAQPLK PQIAMDHEHE DGLGLDNGGG LQSDTSADGA
2200 2201
EFEFDAATVS EHTMLLEGTA NRPPPGSSGP VTGAEIMRKL SKTHTHSDSA
2250 2251
LKIKGIHPYH SLSYTSGDTA TDSPVHVGRA GMPVKDSPRK ESLLSYLTGS
2300 2301
FPSLHNLLEG TPQRSSAAVK SSSLTRTGNT VATDMLSEHP LLSEPSSVSF
2350 2351
YNWMSNAVGN RGSVLQESPV TKSGHNSLPT GVAPNLPTIP SASDFNTVLS
2400 2401
SDQNTLDGTH SQHSTSQDDV AGVEEANQGF PAVQLADAQV VFKPLLSHTG
2450 2451
IQSQDTMPFC YRMYFGEHLS FSGTLDCLRA DIVDSDTAKE RKGKRARRQG
2500 2501
HVNLPPLEFK PALMLGTFSI SAVVMEKSVC TPQNSTSALS FHDLSKRYYN
2550 2551
TFHCNFTISC QSISQHVDMA LVRLIHQFST MIDDIKATQT DIKLSRYTAG
2600 2601
SASPTPTFKT RKHRDFRSSD FSRSSRGSLN GGNRVNNAKN KRTNNENNKK
2650 2651
ESRNKNSLGR SERRTSKVSR KGSKDVVDHM TIHMDDSDSI TVSEQSEPSA
2700 2701
ECWQNMYKLL NFYSLISDPT GILEKSSETF GPAGVRSPTE PTCKVVFENE
2750 2751
QDNSSLTKTQ RKRSLVTSEP QHVTLIVFGI GMVNRTHLEA DIGGLTMESE
2800 2801
LKRIHGSFTL KEKMKDVLHQ KMTETCATAH IGGVNIVLLE GITPNIQLED
2850 2851
FPTSPTSTAK QEFLTVVKCS IAKSQALYSA QRGLKTNNAA VFKVGAISIN
2900 2901
IPQHPATLHS MMVRSSHQLS KQISDLIRQP STAPQPVKED IATPLPSEKT
2950 2951
PTSVNQTPVE TNEFPQLPEG LEKKPIVLKF SAMLDGIAIG AALLPSLKAE
3000 3001
YKMGRMRSHG MTGAQTRFTF ELPNHRLRFT SKVSATDMST IPPSASLNLP
3050 3051
PVTMSGKYIM EEHDSYSDQV WSIDELPSKQ GYYLQGNYLR CVAEVGSFEH
3100 3101
NLTTDLLNHL VFVQKVFMKE VNEVIQKVSG GEQPIPLWNE HDGTADGDKP
3150 3151
KILLYSLNLQ FKGIQVTATT PSMRAVRFET GLIELELSNR LQTKASPGSS
3200 3201
SYLKLFGKCQ VDLNLALGQI VKHQVYEEAG SDFHQVAYFK TRIGLRNALR
3250 3251
EEISGSSDRE AVLITLNRPI VYAQPVAFDR AVLFWLNYKA AYDNWNEQRM
3300 3301
ALHKDIHMAT KEVVDMLPGI QQTSAQAFGT LFLQLTVNDL GICLPITNTA
3350 3351
QSNHTGDLDT GSALVLTIES TLITACSSES LVSKGHFKNF CIRFADGFET
3400 3401
SWDDWKPEIH GDLVMNACVV PDGTYEVCSR TTGQAAAESS SAGTWTLNVL
3450 3451
WKMCGIDVHM DPNIGKRLNA LGNTLTTLTG EEDIDDIADL NSVNIADLSD
3500 3501
EDEVDTMSPT IHTEATDYRR QAASASQPGE LRGRKIMKRI VDIRELNEQA
3550 3551
KVIDDLKKLG ASEGTINQEI QRYQQLESVA VNDIRRDVRK KLRRSSMRAA
3600 3601
SLKDKWGLSY KPSYSRSKSI SASGRPPLKR MERASSRVGE TEELPEIRVD
3650 3651
AASPGPRVTF NIQDTFPEET ELDLLSVTIE GPSHYSSNSE GSCSVFSSPK
3700 3701
TPGGFSPGIP FQTEEGRRDD SLSSTSEDSE KDEKDEDHER ERFYIYRKPS
3750 3751
HTSRKKATGF AAVHQLFTER WPTTPVNRSL SGTATERNID FELDIRVEID
3800 3801
SGKCVLHPTT LLQEHDDISL RRSYDRSSRS LDQDSPSKKK KFQTNYASTT
3850 3851
HLMTGKKVPS SLQTKPSDLE TTVFYIPGVD VKLHYNSKTL KTESPNASRG
3900 3901
SSLPRTLSKE SKLYGMKDSA TSPPSPPLPS TVQSKTNTLL PPQPPPIPAA
3950 3951
KGKGSGGVKT AKLYAWVALQ SLPEEMVISP CLLDFLEKAL ETIPITPVER
4000 4001
NYTAVSSQDE DMGHFEIPDP MEESTTSLVS SSTSAYSSFP VDVVVYVRVQ
4050 4051
PSQIKFSCLP VSRVECMLKL PSLDLVFSSN RGELETLGTT YPAETLSPGG
4100 4101
NATQSGTKTS ASKTGIPGSS GLGSPLGRSR HSSSQSDLTS SSSSSSGLSF
4150 4151
TACMSDFSLY VFHPYGAGKQ KTAVSGLTPG SGGLGNVDEE PTSVTGRKDS
4200 4201
LSINLEFVKV SLSRIRRSGG ASFFESQSVS KSASKMDTTL INISAVCDIG
4250 4251
SASFKYDMRR LSEILAFPRA WYRRSIARRL FLGDQTINLP TSGPGTPDSI
4300 4301
EGVSQHLSPE SSRKAYCKTW EQPSQSASFT HMPQSPNVFN EHMTNSTMSP
4350 4351
GTVGQSLKSP ASIRSRSVSD SSVPRRDSLS KTSTPFNKSN KAASQQGTPW
4400 4401
ETLVVFAINL KQLNVQMNMS NVMGNTTWTT SGLKSQGRLS VGSNRDREIS
4450 4451
MSVGLGRSQL DSKGGVVGGT IDVNALEMVA HISEHPNQQP SHKIQITMGS
4500 4501
TEARVDYMGS SILMGIFSNA DLKLQDEWKV NLYNTLDSSI TDKSEIFVHG
4550 4551
DLKWDIFQVM ISRSTTPDLI KIGMKLQEFF TQQFDTSKRA LSTWGPVPYL
4600 4601
PPKTMTSNLE KSSQEQLLDA AHHRHWPGVL KVVSGCHISL FQIPLPEDGM
4650 4651
QFGGSMSLHG NHMTLACFHG PNFRSKSWAL FHLEEPNIAF WTEAQKIWED
4700 4701
GSSDHSTYIV QTLDFHLGHN TMVTKPCGAL ESPMATITKI TRRRHENPPH
4750 4751
GVASVKEWFN YVTATRNEEL NLLRNVDANN TENSTTVKNS SLLSGFRGGS
4800 4801
SYNHETETIF ALPRMQLDFK SIHVQEPQEP SLQDASLKPK VECSVVTEFT
4850 4851
DHICVTMDAE LIMFLHDLVS AYLKEKEKAI FPPRILSTRP GQKSPIIIHD
4900 4901
DNSSDKDRED SITYTTVDWR DFMCNTWHLE PTLRLISWTG RKIDPVGVDY
4950 4951
ILQKLGFHHA RTTIPKWLQR GVMDPLDKVL SVLIKKLGTA LQDEKEKKGK
5000 5001
DKEEH
5005
Show the unformatted sequence. |
| Checksums: |
CRC64:8EF3E5E73AF2A37D
MD5:c611fbcbfb4885a88bc9fb976b413ae3
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
