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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TSR1_HUMAN (Q2NL82)

Summary

This is the summary of UniProt entry TSR1_HUMAN (Q2NL82).

Description: Pre-rRNA-processing protein TSR1 homolog
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 804 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 76
low_complexity n/a 17 24
disorder n/a 80 83
disorder n/a 86 87
Pfam AARP2CN 228 308
disorder n/a 303 331
disorder n/a 339 383
low_complexity n/a 383 398
disorder n/a 387 388
disorder n/a 400 463
low_complexity n/a 406 452
disorder n/a 470 472
disorder n/a 474 476
disorder n/a 480 488
Pfam RIBIOP_C 488 775
low_complexity n/a 541 554
disorder n/a 801 803

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q2NL82. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAHRPGPLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR
50
51
VDQRHRASQL RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM
100
101
QLLQDRDTGT VHLNELGNTQ NFMLLCPRLK HRWFFTSARP GDLHVVLDMA
150
151
KVADTILFLL DPLEGWDSTG DYCLSCLFAQ GLPTYTLAVQ GISGLPLKKQ
200
201
IDTRKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK QQHLAFRDRR
250
251
AYLFAHAVDF VPSEENNLVG TLKISGYVRG QTLNVNRLLH IVGYGDFQMK
300
301
QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDAVDDMEEG LKVLMKADPG
350
351
RQESLQAEVI PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY
400
401
QAEWILDGGS QSGGEGDEYE YDDMEHEDFM EEESQDESSE EEEEYETMTI
450
451
GESVHDDLYD KKVDEEAEAK MLEKYKQERL EEMFPDEVDT PRDVAARIRF
500
501
QKYRGLKSFR TSPWDPKENL PQDYARIFQF QNFTNTRKSI FKEVEEKEVE
550
551
GAEVGWYVTL HVSEVPVSVV ECFRQGTPLI AFSLLPHEQK MSVLNMVVRR
600
601
DPGNTEPVKA KEELIFHCGF RRFRASPLFS QHTAADKHKL QRFLTADMAL
650
651
VATVYAPITF PPASVLLFKQ KSNGMHSLIA TGHLMSVDPD RMVIKRVVLS
700
701
GHPFKIFTKM AVVRYMFFNR EDVLWFKPVE LRTKWGRRGH IKEPLGTHGH
750
751
MKCSFDGKLK SQDTVLMNLY KRVFPKWTYD PYVPEPVPWL KSEISSTVPQ
800
801
GGME                                                  
804
 

Show the unformatted sequence.

Checksums:
CRC64:EDDBE6AD04E7F3A7
MD5:a8d59c537abcf934ffadd04389719934

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AARP2CN 228 - 308 6G18 u 228 - 308 Jmol OpenAstexViewer
6G4S u 228 - 308 Jmol OpenAstexViewer
6G4W u 228 - 308 Jmol OpenAstexViewer
6G51 u 228 - 308 Jmol OpenAstexViewer
6G53 u 228 - 308 Jmol OpenAstexViewer
RIBIOP_C 488 - 775 6G18 u 488 - 775 Jmol OpenAstexViewer
6G4S u 488 - 775 Jmol OpenAstexViewer
6G4W u 488 - 775 Jmol OpenAstexViewer
6G51 u 488 - 775 Jmol OpenAstexViewer
6G53 u 488 - 775 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.