Summary
This is the summary of UniProt entry TSR1_HUMAN (Q2NL82).
| Description: | Pre-rRNA-processing protein TSR1 homolog |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 804 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 76 |
| low_complexity | n/a | 17 | 24 |
| disorder | n/a | 80 | 83 |
| disorder | n/a | 86 | 87 |
| Pfam | AARP2CN | 228 | 308 |
| disorder | n/a | 303 | 331 |
| disorder | n/a | 339 | 383 |
| low_complexity | n/a | 383 | 398 |
| disorder | n/a | 387 | 388 |
| disorder | n/a | 400 | 463 |
| low_complexity | n/a | 406 | 452 |
| disorder | n/a | 470 | 472 |
| disorder | n/a | 474 | 476 |
| disorder | n/a | 480 | 488 |
| Pfam | RIBIOP_C | 488 | 775 |
| low_complexity | n/a | 541 | 554 |
| disorder | n/a | 801 | 803 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q2NL82. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAAHRPGPLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR
50 51
VDQRHRASQL RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM
100 101
QLLQDRDTGT VHLNELGNTQ NFMLLCPRLK HRWFFTSARP GDLHVVLDMA
150 151
KVADTILFLL DPLEGWDSTG DYCLSCLFAQ GLPTYTLAVQ GISGLPLKKQ
200 201
IDTRKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK QQHLAFRDRR
250 251
AYLFAHAVDF VPSEENNLVG TLKISGYVRG QTLNVNRLLH IVGYGDFQMK
300 301
QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDAVDDMEEG LKVLMKADPG
350 351
RQESLQAEVI PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY
400 401
QAEWILDGGS QSGGEGDEYE YDDMEHEDFM EEESQDESSE EEEEYETMTI
450 451
GESVHDDLYD KKVDEEAEAK MLEKYKQERL EEMFPDEVDT PRDVAARIRF
500 501
QKYRGLKSFR TSPWDPKENL PQDYARIFQF QNFTNTRKSI FKEVEEKEVE
550 551
GAEVGWYVTL HVSEVPVSVV ECFRQGTPLI AFSLLPHEQK MSVLNMVVRR
600 601
DPGNTEPVKA KEELIFHCGF RRFRASPLFS QHTAADKHKL QRFLTADMAL
650 651
VATVYAPITF PPASVLLFKQ KSNGMHSLIA TGHLMSVDPD RMVIKRVVLS
700 701
GHPFKIFTKM AVVRYMFFNR EDVLWFKPVE LRTKWGRRGH IKEPLGTHGH
750 751
MKCSFDGKLK SQDTVLMNLY KRVFPKWTYD PYVPEPVPWL KSEISSTVPQ
800 801
GGME
804
Show the unformatted sequence. |
| Checksums: |
CRC64:EDDBE6AD04E7F3A7
MD5:a8d59c537abcf934ffadd04389719934
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| AARP2CN | 228 - 308 | 6G18 | u | 228 - 308 | Jmol OpenAstexViewer |
| 6G4S | u | 228 - 308 | Jmol OpenAstexViewer | ||
| 6G4W | u | 228 - 308 | Jmol OpenAstexViewer | ||
| 6G51 | u | 228 - 308 | Jmol OpenAstexViewer | ||
| 6G53 | u | 228 - 308 | Jmol OpenAstexViewer | ||
| RIBIOP_C | 488 - 775 | 6G18 | u | 488 - 775 | Jmol OpenAstexViewer |
| 6G4S | u | 488 - 775 | Jmol OpenAstexViewer | ||
| 6G4W | u | 488 - 775 | Jmol OpenAstexViewer | ||
| 6G51 | u | 488 - 775 | Jmol OpenAstexViewer | ||
| 6G53 | u | 488 - 775 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
