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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DRB5_HUMAN (Q30154)

Summary

This is the summary of UniProt entry DRB5_HUMAN (Q30154).

Description: HLA class II histocompatibility antigen, DR beta 5 chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 266 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 29
Pfam MHC_II_beta 42 116
Pfam C1-set 128 209
transmembrane n/a 228 250
low_complexity n/a 228 246
disorder n/a 261 262

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q30154. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVCLKLPGGS YMAKLTVTLM VLSSPLALAG DTRPRFLQQD KYECHFFNGT
50
51
ERVRFLHRDI YNQEEDLRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR
100
101
RAAVDTYCRH NYGVGESFTV QRRVEPKVTV YPARTQTLQH HNLLVCSVNG
150
151
FYPGSIEVRW FRNSQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
200
201
TCQVEHPSVT SPLTVEWRAQ SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
250
251
KNQKGHSGLH PTGLVS                                     
266
 

Show the unformatted sequence.

Checksums:
CRC64:0D4335BAEEA6AF22
MD5:b0ca3cbe9600c395306bf5b5249966a2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1-set 128 - 209 1FV1 B 99 - 180 Jmol OpenAstexViewer
E 99 - 180 Jmol OpenAstexViewer
1H15 B 99 - 180 Jmol OpenAstexViewer
E 99 - 180 Jmol OpenAstexViewer
1HQR B 299 - 380 Jmol OpenAstexViewer
1ZGL B 99 - 180 Jmol OpenAstexViewer
E 99 - 180 Jmol OpenAstexViewer
H 99 - 180 Jmol OpenAstexViewer
K 99 - 180 Jmol OpenAstexViewer
MHC_II_beta 42 - 116 1FV1 B 13 - 87 Jmol OpenAstexViewer
E 13 - 87 Jmol OpenAstexViewer
1H15 B 13 - 87 Jmol OpenAstexViewer
E 13 - 87 Jmol OpenAstexViewer
1HQR B 213 - 287 Jmol OpenAstexViewer
1ZGL B 13 - 87 Jmol OpenAstexViewer
E 13 - 87 Jmol OpenAstexViewer
H 13 - 87 Jmol OpenAstexViewer
K 13 - 87 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.