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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: SHSA3_MOUSE (Q3UPR0)

Summary

This is the summary of UniProt entry SHSA3_MOUSE (Q3UPR0).

Description: Protein shisa-3 homolog
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 238 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 21
low_complexity n/a 2 14
Pfam Shisa 25 196
transmembrane n/a 95 121
low_complexity n/a 151 179
disorder n/a 160 168
disorder n/a 228 236

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q3UPR0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGALLAFCLL VGLLRWGPAG AQQPGEYCHG WVDAQGNYHE GFQCPEDFDT
50
51
QDATICCGSC ALRYCCAAAD ARLEQGGCTN DRGELEHPGI TAQPVYVPFL
100
101
IVGSIFIAFI ILGSLVAIYC CTCLRPKEPS QQPIRFSLRS YQTETLPMIL
150
151
TSTSLRAASR QSSTATSSSS TGGSVRRFSF ARAEPSCLVP SSPPPYTTGH
200
201
TIHLTQPSGF LVSPQYFAYP LQQEPPLPGK SCPDFSSS             
238
 

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Checksums:
CRC64:45367725C66E178F
MD5:0450833d2cb77d8db0ed974f1ca61623

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Shisa 25 - 84 5M0W A 25 - 84 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;