Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DKGA_ECOLI (Q46857)

Summary

This is the summary of UniProt entry DKGA_ECOLI (Q46857).

Description: 2,5-diketo-D-gluconic acid reductase A EC=1.1.1.274
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
View Pfam proteome data.
Length: 275 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Aldo_ket_red 17 203
Pfam Aldo_ket_red 198 262
disorder n/a 259 261
disorder n/a 265 275

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q46857. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MANPTVIKLQ DGNVMPQLGL GVWQASNEEV ITAIQKALEV GYRSIDTAAA
50
51
YKNEEGVGKA LKNASVNREE LFITTKLWND DHKRPREALL DSLKKLQLDY
100
101
IDLYLMHWPV PAIDHYVEAW KGMIELQKEG LIKSIGVCNF QIHHLQRLID
150
151
ETGVTPVINQ IELHPLMQQR QLHAWNATHK IQTESWSPLA QGGKGVFDQK
200
201
VIRDLADKYG KTPAQIVIRW HLDSGLVVIP KSVTPSRIAE NFDVWDFRLD
250
251
KDELGEIAKL DQGKRLGPDP DQFGG                           
275
 

Show the unformatted sequence.

Checksums:
CRC64:0FF6E140411BAD43
MD5:88e41fc450178b85b56d7a3a9feda349

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Aldo_ket_red 17 - 203 1MZR A 18 - 204 Jmol OpenAstexViewer
B 18 - 204 Jmol OpenAstexViewer
198 - 262 1MZR A 199 - 263 Jmol OpenAstexViewer
B 199 - 263 Jmol OpenAstexViewer