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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CDON_HUMAN (Q4KMG0)

Summary

This is the summary of UniProt entry CDON_HUMAN (Q4KMG0).

Description: Cell adhesion molecule-related/down-regulated by oncogenes
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1287 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 25
Pfam Ig_3 28 101
low_complexity n/a 85 92
Pfam Ig_3 221 294
Pfam I-set 312 397
Pfam Ig_3 404 504
low_complexity n/a 453 464
disorder n/a 454 461
disorder n/a 498 503
disorder n/a 511 517
disorder n/a 526 551
disorder n/a 561 571
disorder n/a 574 587
Pfam fn3 578 667
disorder n/a 592 598
disorder n/a 626 630
disorder n/a 636 639
disorder n/a 665 695
disorder n/a 710 711
disorder n/a 713 729
Pfam fn3 722 807
Pfam fn3 826 916
disorder n/a 875 879
disorder n/a 932 934
disorder n/a 936 954
transmembrane n/a 964 989
disorder n/a 1081 1085
disorder n/a 1095 1096
low_complexity n/a 1110 1120
disorder n/a 1125 1126
low_complexity n/a 1129 1139
disorder n/a 1132 1143
disorder n/a 1171 1177
disorder n/a 1179 1182
disorder n/a 1194 1196
disorder n/a 1200 1214
disorder n/a 1262 1287

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q4KMG0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MHPDLGPLCT LLYVTLTILC SSVSSDLAPY FTSEPLSAVQ KLGGPVVLHC
50
51
SAQPVTTRIS WLHNGKTLDG NLEHVKIHQG TLTILSLNSS LLGYYQCLAN
100
101
NSIGAIVSGP ATVSVAVLGD FGSSTKHVIT AEEKSAGFIG CRVPESNPKA
150
151
EVRYKIRGKW LEHSTENYLI LPSGNLQILN VSLEDKGSYK CAAYNPVTHQ
200
201
LKVEPIGRKL LVSRPSSDDV HILHPTHSQA LAVLSRSPVT LECVVSGVPA
250
251
PQVYWLKDGQ DIAPGSNWRR LYSHLATDSV DPADSGNYSC MAGNKSGDVK
300
301
YVTYMVNVLE HASISKGLQD QIVSLGATVH FTCDVHGNPA PNCTWFHNAQ
350
351
PIHPSARHLT AGNGLKISGV TVEDVGMYQC VADNGIGFMH STGRLEIEND
400
401
GGFKPVIITA PVSAKVADGD FVTLSCNASG LPVPVIRWYD SHGLITSHPS
450
451
QVLRSKSRKS QLSRPEGLNL EPVYFVLSQA GASSLHIQAV TQEHAGKYIC
500
501
EAANEHGTTQ AEASLMVVPF ETNTKAETVT LPDAAQNDDR SKRDGSETGL
550
551
LSSFPVKVHP SAVESAPEKN ASGISVPDAP IILSPPQTHT PDTYNLVWRA
600
601
GKDGGLPINA YFVKYRKLDD GVGMLGSWHT VRVPGSENEL HLAELEPSSL
650
651
YEVLMVARSA AGEGQPAMLT FRTSKEKTAS SKNTQASSPP VGIPKYPVVS
700
701
EAANNNFGVV LTDSSRHSGV PEAPDRPTIS TASETSVYVT WIPRANGGSP
750
751
ITAFKVEYKR MRTSNWLVAA EDIPPSKLSV EVRSLEPGST YKFRVIAINH
800
801
YGESFRSSAS RPYQVVGFPN RFSSRPITGP HIAYTEAVSD TQIMLKWTYI
850
851
PSSNNNTPIQ GFYIYYRPTD SDNDSDYKRD VVEGSKQWHM IGHLQPETSY
900
901
DIKMQCFNEG GESEFSNVMI CETKVKRVPG ASEYPVKDLS TPPNSLGSGG
950
951
NVGPATSPAR SSDMLYLIVG CVLGVMVLIL MVFIAMCLWK NRQQNTIQKY
1000
1001
DPPGYLYQGS DMNGQMVDYT TLSGASQING NVHGGFLTNG GLSSGYSHLH
1050
1051
HKVPNAVNGI VNGSLNGGLY SGHSNSLTRT HVDFEHPHHL VNGGGMYTAV
1100
1101
PQIDPLECVN CRNCRNNNRC FTKTNSTFSS SPPPVVPVVA PYPQDGLEMK
1150
1151
PLSHVKVPVC LTSAVPDCGQ LPEESVKDNV EPVPTQRTCC QDIVNDVSSD
1200
1201
GSEDPAEFSR GQEGMINLRI PDHLQLAKSC VWEGDSCAHS ETEINIVSWN
1250
1251
ALILPPVPEG CAEKTMWSPP GIPLDSPTEV LQQPRET              
1287
 

Show the unformatted sequence.

Checksums:
CRC64:B7870C66F5224BBE
MD5:c01cadb015df1bcc6e8bc77a8d0fea23

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
fn3 826 - 916 3D1M D 826 - 916 Show 3D Structure View in InterPro
3N1F C 826 - 916 Show 3D Structure View in InterPro
D 826 - 916 Show 3D Structure View in InterPro
829 - 916 3D1M C 829 - 916 Show 3D Structure View in InterPro
3N1Q C 829 - 916 Show 3D Structure View in InterPro
D 829 - 916 Show 3D Structure View in InterPro
F 829 - 916 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;