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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GREB1_HUMAN (Q4ZG55)

Summary

This is the summary of UniProt entry GREB1_HUMAN (Q4ZG55).

Description: Protein GREB1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1949 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam GREB1 1 1103
disorder n/a 1 2
low_complexity n/a 39 52
disorder n/a 51 77
low_complexity n/a 60 71
disorder n/a 81 82
disorder n/a 237 240
disorder n/a 242 274
disorder n/a 286 288
disorder n/a 302 334
low_complexity n/a 437 450
low_complexity n/a 479 495
disorder n/a 1081 1210
low_complexity n/a 1122 1147
low_complexity n/a 1210 1233
disorder n/a 1213 1222
disorder n/a 1224 1228
disorder n/a 1233 1235
Pfam GREB1_C 1256 1949
disorder n/a 1328 1329
disorder n/a 1544 1546
low_complexity n/a 1619 1630
low_complexity n/a 1865 1881
transmembrane n/a 1869 1888

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q4ZG55. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNSYAGQLK TTRFEEVLHN SIEASLRSNN LVPRPIFSQL YLEAEQQLAA
50
51
LEGGSRVDNE EEEEEGEGGL ETNGPPNPFQ LHPLPEGCCT TDGFCQAGKD
100
101
LRLVSISNEP MDVPAGFLLV GVKSPSLPDH LLVCAVDKRF LPDDNGHNAL
150
151
LGFSGNCVGC GKKGFCYFTE FSNHINLKLT TQPKKQKHLK YYLVRNAQGT
200
201
LTKGPLICWK GSEFRSRQIP ASTCSSSLFP ALESTAAFPS EPVPGTNPSI
250
251
LMGAQQAGPA SDHPSLNAAM GPAVFNGKDS PKCQQLAKNN LLALPRPSAL
300
301
GILSNSGPPK KRHKGWSPES PSAPDGGCPQ GGGNRAKYES AGMSCVPQVG
350
351
LVGPASVTFP VVASGEPVSV PDNLLKICKA KPVIFKGHGN FPYLCGNLND
400
401
VVVSPLLYTC YQNSQSVSRA YEQYGASAIQ PISEEMQLLL TVYYLVQLAA
450
451
DQVPLMEDLE QIFLRSWRES HLTEIRQYQQ APPQPFPPAP SAAAPVTSAQ
500
501
LPWLASLAAS SCNDSVHVIE CAYSLAEGLS EMFRLLVEGK LAKTNYVVII
550
551
CACRSAAIDS CIAVTGKYQA RILSESLLTP AEYQKEVNYE LVTGKVDSLG
600
601
AFFSTLCPEG DIDILLDKFH QENQGHISSS LAASSVTKAA SLDVSGTPVC
650
651
TSYNLEPHSI RPFQLAVAQK LLSHVCSIAD SSTQNLDLGS FEKVDFLICI
700
701
PPSEVTYQQT LLHVWHSGVL LELGLKKEHM TKQRVEQYVL KLDTEAQTKF
750
751
KAFLQNSFQN PHTLFVLIHD HAHWDLVSST VHNLYSQSDP SVGLVDRLLN
800
801
CREVKEAPNI VTLHVTSFPY ALQTQHTLIS PYNEIHWPAS CSNGVDLYHE
850
851
NKKYFGLSEF IESTLSGHSL PLLRYDSSFE AMVTALGKRF PRLHSAVIRT
900
901
FVLVQHYAAA LMAVSGLPQM KNYTSVETLE ITQNLLNSPK QCPCGHGLMV
950
951
LLRVPCSPLA VVAYERLAHV RARLALEEHF EIILGSPSSG VTVGKHFVKQ
1000
1001
LRMWQKIEDV EWRPQTYLEL EGLPCILIFS GMDPHGESLP RSLRYCDLRL
1050
1051
INSSCLVRTA LEQELGLAAY FVSNEVPLEK GARNEALESD AEKLSSTDNE
1100
1101
DEELGTEGST SEKRSPMKRE RSRSHDSASS SLSSKASGSA LGGESSAQPT
1150
1151
ALPQGEHARS PQPRGPAEEG RAPGEKQRPR ASQGPPSAIS RHSPGPTPQP
1200
1201
DCSLRTGQRS VQVSVTSSCS QLSSSSGSSS SSVAPAAGTW VLQASQCSLT
1250
1251
KACRQPPIVF LPKLVYDMVV STDSSGLPKA ASLLPSPSVM WASSFRPLLS
1300
1301
KTMTSTEQSL YYRQWTVPRP SHMDYGNRAE GRVDGFHPRR LLLSGPPQIG
1350
1351
KTGAYLQFLS VLSRMLVRLT EVDVYDEEEI NINLREESDW HYLQLSDPWP
1400
1401
DLELFKKLPF DYIIHDPKYE DASLICSHYQ GIKSEDRGMS RKPEDLYVRR
1450
1451
QTARMRLSKY AAYNTYHHCE QCHQYMGFHP RYQLYESTLH AFAFSYSMLG
1500
1501
EEIQLHFIIP KSKEHHFVFS QPGGQLESMR LPLVTDKSHE YIKSPTFTPT
1550
1551
TGRHEHGLFN LYHAMDGASH LHVLVVKEYE MAIYKKYWPN HIMLVLPSIF
1600
1601
NSAGVGAAHF LIKELSYHNL ELERNRQEEL GIKPQDIWPF IVISDDSCVM
1650
1651
WNVVDVNSAG ERSREFSWSE RNVSLKHIMQ HIEAAPDIMH YALLGLRKWS
1700
1701
SKTRASEVQE PFSRCHVHNF IILNVDLTQN VQYNQNRFLC DDVDFNLRVH
1750
1751
SAGLLLCRFN RFSVMKKQIV VGGHRSFHIT SKVSDNSAAV VPAQYICAPD
1800
1801
SKHTFLAAPA QLLLEKFLQH HSHLFFPLSL KNHDHPVLSV DCYLNLGSQI
1850
1851
SVCYVSSRPH SLNISCSDLL FSGLLLYLCD SFVGASFLKK FHFLKGATLC
1900
1901
VICQDRSSLR QTVVRLELED EWQFRLRDEF QTANAREDRP LFFLTGRHI 
1949
 

Show the unformatted sequence.

Checksums:
CRC64:BA12C0535B166BC4
MD5:7f44e8704ae7594efc3fb38494fb28d8

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;