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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HECD3_HUMAN (Q5T447)

Summary

This is the summary of UniProt entry HECD3_HUMAN (Q5T447).

Description: E3 ubiquitin-protein ligase HECTD3 EC=2.3.2.26
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 861 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 5
low_complexity n/a 26 41
low_complexity n/a 76 88
disorder n/a 77 79
disorder n/a 82 91
disorder n/a 154 155
Pfam ANAPC10 232 393
Pfam HECT 562 852
disorder n/a 580 583

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q5T447. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGPGPGAVL ESPRQLLGRV RFLAEAARSL RAGRPLPAAL AFVPREVLYK
50
51
LYKDPAGPSR VLLPVWEAEG LGLRVGAAGP APGTGSGPLR AARDSIELRR
100
101
GACVRTTGEE LCNGHGLWVK LTKEQLAEHL GDCGLQEGWL LVCRPAEGGA
150
151
RLVPIDTPNH LQRQQQLFGV DYRPVLRWEQ VVDLTYSHRL GSRPQPAEAY
200
201
AEAVQRLLYV PPTWTYECDE DLIHFLYDHL GKEDENLGSV KQYVESIDVS
250
251
SYTEEFNVSC LTDSNADTYW ESDGSQCQHW VRLTMKKGTI VKKLLLTVDT
300
301
TDDNFMPKRV VVYGGEGDNL KKLSDVSIDE TLIGDVCVLE DMTVHLPIIE
350
351
IRIVECRDDG IDVRLRGVKI KSSRQRELGL NADLFQPTSL VRYPRLEGTD
400
401
PEVLYRRAVL LQRFIKILDS VLHHLVPAWD HTLGTFSEIK QVKQFLLLSR
450
451
QRPGLVAQCL RDSESSKPSF MPRLYINRRL AMEHRACPSR DPACKNAVFT
500
501
QVYEGLKPSD KYEKPLDYRW PMRYDQWWEC KFIAEGIIDQ GGGFRDSLAD
550
551
MSEELCPSSA DTPVPLPFFV RTANQGNGTG EARDMYVPNP SCRDFAKYEW
600
601
IGQLMGAALR GKEFLVLALP GFVWKQLSGE EVSWSKDFPA VDSVLVKLLE
650
651
VMEGMDKETF EFKFGKELTF TTVLSDQQVV ELIPGGAGIV VGYGDRSRFI
700
701
QLVQKARLEE SKEQVAAMQA GLLKVVPQAV LDLLTWQELE KKVCGDPEVT
750
751
VDALRKLTRF EDFEPSDSRV QYFWEALNNF TNEDRSRFLR FVTGRSRLPA
800
801
RIYIYPDKLG YETTDALPES STCSSTLFLP HYASAKVCEE KLRYAAYNCV
850
851
AIDTDMSPWE E                                          
861
 

Show the unformatted sequence.

Checksums:
CRC64:91009CE9FB84F4E7
MD5:f70d4ce7fe9b336ff50c780866b784fe

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;